|Table of Contents|

Mechanism of PDT and its application in lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 23
Page:
4531-4538
Research Field:
Publishing date:

Info

Title:
Mechanism of PDT and its application in lung cancer
Author(s):
LI Xiangzhen1LIU Tianjun2
1.Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;2.Tianjin Key Laboratory of Biomedical Materials,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China.
Keywords:
photodynamic therapyphotosensitizerslung cancersubcellular localization
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2024.23.017
Abstract:
Lung cancer is one of the most common cancers,and a new type of treatment-photodynamic therapy (PDT),has received a lot of attention in recent years.Compared with traditional therapies,PDT is more selective to tumor cells because the photosensitizers used can be better positioned in tumor lesions to directly kill cells through apoptosis or necrosis and destruction of tumor blood vessels.This review mainly introduces the principle and mechanism of PDT,the research on subcellular localization and its application in lung cancer,and introduces the challenges and prospects of PDT.

References:

[1]SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
[2]SIMONE CB,FRIEDBERG JS,GLATSTEIN E,et al.Photodynamic therapy for the treatment of non-small cell lung cancer[J].Journal of Thoracic Disease,2012,4(1):63-75.
[3]WOLF AMD,OEFFINGER KC,SHIH TYC,et al.Screening for lung cancer:2023 guideline update from the American cancer society[J].CA:A Cancer Journal for Clinicians,2024,74(1):50-81.
[4]CORREIA JH,RODRIGUES JA,PIMENTA S,et al.Photodynamic therapy review:Principles,photosensitizers,applications,and future directions[J].Pharmaceutics,2021,13(9):1332.
[5]MFOUO-TYNGA I,ABRAHAMSE H.Cell death pathways and phthalocyanine as an efficient agent for photodynamic cancer therapy[J].International Journal of Molecular Sciences,2015,16(5):10228-10241.
[6]LI X,ZHAO Y,ZHANG T,et al.Mitochondria-specific agents for photodynamic cancer therapy:A key determinant to boost the efficacy[J].Advanced Healthcare Materials,2021,10(3):2001240.
[7]CHEN D,XU Q,WANG W,et al.Type I photosensitizers revitalizing photodynamic oncotherapy[J].Small(Weinheim an Der Bergstrasse,Germany),2021,17(31):e2006742.
[8]LEE CN,HSU R,CHEN H,et al.Daylight photodynamic therapy:An update[J].Molecules(Basel,Switzerland),2020,25(21):5195.
[9]ABRAHAMSE H,HAMBLIN MR.New photosensitizers for photodynamic therapy[J].The Biochemical Journal,2016,473(4):347-364.
[10]CHEN J,FAN T,XIE Z,et al.Advances in nanomaterials for photodynamic therapy applications:Status and challenges[J].Biomaterials,2020,237:119827.
[11]GEMMELL NR,MCCARTHY A,KIM MM,et al.A compact fiber-optic probe-based singlet oxygen luminescence detection system[J].Journal of Biophotonics,2017,10(2):320-326.
[12]CASTANO AP,MROZ P,HAMBLIN MR.Photodynamic therapy and anti-tumour immunity[J].Nature Reviews,Cancer,2006,6(7):535-545.
[13]KESSEL D.Subcellular targeting as a determinant of the efficacy of photodynamic therapy[J].Photochemistry and Photobiology,2017,93(2):609-612.
[14]DING B,SHAO S,YU C,et al.Large-pore mesoporous-silica-coated upconversion nanoparticles as multifunctional immunoadjuvants with ultrahigh photosensitizer and antigen loading efficiency for improved cancer photodynamic immunotherapy[J].Advanced Materials(Deerfield Beach,Fla.),2018,30(52):e1802479.
[15]MASSCHELIN PM,COX AR,CHERNIS N,et al.The impact of oxidative stress on adipose tissue energy balance[J].Frontiers in Physiology,2020,10:1638.
[16]WALLACE DC.A mitochondrial paradigm of metabolic and degenerative diseases,aging,and cancer:a dawn for evolutionary medicine[J].Annual Review of Genetics,2005,39:359-407.
[17]GUO X,YANG N,JI W,et al.Mito-bomb:Targeting mitochondria for cancer therapy[J].Advanced Materials,2021,33(43):2007778.
[18]ASHKENAZI A,SALVESEN G.Regulated cell death:signaling and mechanisms[J].Annual Review of Cell and Developmental Biology,2014,30:337-356.
[19]FULDA S.Targeting apoptosis for anticancer therapy[J].Seminars in Cancer Biology,2015,31:84-88.
[20]HERR I,DEBATIN KM.Cellular stress response and apoptosis in cancer therapy[J].Blood,2001,98(9):2603-2614.
[21]DEBATIN KM.Apoptosis pathways in cancer and cancer therapy[J].Cancer Immunology,Immunotherapy,2004,53(3):153-159.
[22]LIU X,CHEN L,CHEN Z.Acid-triggered controlled release and fluorescence-switchable phthalocyanine nanoassemblies combined with O2-economizer for tumor imaging and collaborative photodynamic antitumor therapy[J].Bioorganic Chemistry,2024,143:106986.
[23]ZIELONKA J,JOSEPH J,SIKORA A,et al.Mitochondria-targeted triphenylphosphonium-based compounds:Syntheses,mechanisms of action,and therapeutic and diagnostic applications[J].Chemical Reviews,2017,117(15):10043-10120.
[24]SMITH RAJ,PORTEOUS CM,GANE AM,et al.Delivery of bioactive molecules to mitochondria in vivo[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(9):5407-5412.
[25]RAJAPUTRA P,NKEPANG G,WATLEY R.Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria[J].Bioorganic & Medicinal Chemistry,2013,21(2):379-387.
[26]WANG Y,LIU T,ZHANG E,et al.Preferential accumulation of the near infrared heptamethine dye IR-780 in the mitochondria of drug-resistant lung cancer cells[J].Biomaterials,2014,35(13):4116-4124.
[27]ZHOU Y,XIA W,LIU C,et al.A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy[J].Biomaterials Science,2022,10(7):1742-1751.
[28]WU C,JIAO Q,WANG C,et al.Nanofibrillar peptide hydrogels for self-delivery of lonidamine and synergistic photodynamic therapy[J].Acta Biomaterialia,2023,155:139-153.
[29]ZHANG SX,WANG JJ,STARR CR,et al.The endoplasmic reticulum:Homeostasis and crosstalk in retinal health and disease[J].Progress in Retinal and Eye Research,2024,98:101231.
[30]XU L,ZHANG PP,FANG XQ,et al.A ruthenium(II) complex containing a p-cresol group induces apoptosis in human cervical carcinoma cells through endoplasmic reticulum stress and reactive oxygen species production[J].Journal of Inorganic Biochemistry,2019,191:126-134.
[31]RAO RV,HERMEL E,CASTRO-OBREGON S,et al.Coupling endoplasmic reticulum stress to the cell death program.Mechanism of caspase activation[J].The Journal of Biological Chemistry,2001,276(36):33869-33874.
[32]HARDING HP,NOVOA I,ZHANG Y,et al.Regulated translation initiation controls stress-induced gene expression in mammalian cells[J].Molecular Cell,2000,6(5):1099-1108.
[33]DENIAUD A,SHARAF EL DEIN O,MAILLIER E,et al.Endoplasmic reticulum stress induces calcium-dependent permeability transition,mitochondrial outer membrane permeabilization and apoptosis[J].Oncogene,2008,27(3):285-299.
[34]ZHANG X,WAN J,MO F,et al.Targeting bone tumor and subcellular endoplasmic reticulum via near infrared II fluorescent polymer for photodynamic-immunotherapy to break the step-reduction delivery dilemma[J].Advanced Science(Weinheim,Baden-Wurttemberg,Germany),2022,9(24):e2201819.
[35]RIZZOLLO F,MORE S,VANGHELUWE P,et al.The lysosome as a master regulator of iron metabolism[J].Trends in Biochemical Sciences,2021,46(12):960-975.
[36]BALLABIO A,BONIFACINO JS.Lysosomes as dynamic regulators of cell and organismal homeostasis[J].Nature Reviews,Molecular Cell Biology,2020,21(2):101-118.
[37]WANG Z,SHEN N,WANG Z,et al.TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation[J].Cell Death and Differentiation,2024,31(1):53-64.
[38]WEBER RA,YEN FS,NICHOLSON SPV,et al.Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation[J].Molecular Cell,2020,77(3):645-655.e7.
[39]CHEN Y,YANG Z,WANG S,et al.Boosting ros-mediated lysosomal membrane permeabilization for cancer ferroptosis therapy[J].Advanced Healthcare Materials,2023,12(6):e2202150.
[40]CHANG SH,LIN PY,WU TK,et al.Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells[J].Journal of Dermatological Science,2022,107(3):142-150.
[41]HAMBLIN MR.Photodynamic therapy for cancer:What's past is prologue[J].Photochemistry and Photobiology,2020,96(3):506-516.
[42]CHIZENGA EP,ABRAHAMSE H.Nanotechnology in modern photodynamic therapy of cancer:A review of cellular resistance patterns affecting the therapeutic response[J].Pharmaceutics,2020,12(7):632.
[43]SINGH N,SEN GUPTA R,BOSE S.A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer[J].Nanoscale,2024,16(7):3243-3268.
[44]KATO H,HARADA M,ICHINOSE S,et al.Photodynamic therapy(PDT) of lung cancer:experience of the Tokyo medical university[J].Photodiagnosis and Photodynamic Therapy,2004,1(1):49-55.
[45]BALCHUM OJ,DOIRON DR,HUTH GC.HpD photodynamic therapy for obstructing lung cancer[J].Progress in Clinical and Biological Research,1984,170:727-745.
[46]MOGHISSI K,DIXON K,STRINGER M,et al.The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer:experience of 100 cases[J].European Journal of Cardio-Thoracic Surgery,1999,15(1):1-6.
[47]LAM S,KOSTASHUK EC,COY EP,et al.A randomized comparative study of the safety and efficacy of photodynamic therapy using Photofrin II combined with palliative radiotherapy versus palliative radiotherapy alone in patients with inoperable obstructive non-small cell bronchogenic carcinoma[J].Photochemistry and Photobiology,1987,46(5):893-897.
[48]DIAZ-JIMENEZ JP,MARTINEZ-BALLARIN JE,LLUNELL A,et al.Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction[J].The European Respiratory Journal,1999,14(4):800-805.
[49]KIMURA M,MIYAJIMA K,KOJIKA M,et al.Photodynamic therapy(PDT) with chemotherapy for advanced lung cancer with airway stenosis[J].International Journal of Molecular Sciences,2015,16(10):25466-25475.
[50]CHHATRE S,VACHANI A,ALLISON RR,et al.Survival outcomes with photodynamic therapy,chemotherapy and radiation in patients with stage Ⅲ or stage Ⅳ non-small cell lung cancer[J].Cancers,2021,13(4):803.
[51]FURUSE K,FUKUOKA M,KATO H,et al.A prospective phase Ⅱ study on photodynamic therapy with photofrin Ⅱ for centrally located early-stage lung cancer.The Japan lung cancer photodynamic therapy study group[J].Journal of Clinical Oncology,1993,11(10):1852-1857.
[52]KATO H,OKUNAKA T,SHIMATANI H.Photodynamic therapy for early stage bronchogenic carcinoma[J].Journal of Clinical Laser Medicine & Surgery,1996,14(5):235-238.
[53]FURUKAWA K,KATO H,KONAKA C,et al.Locally recurrent central-type early stage lung cancer <1.0 cm in diameter after complete remission by photodynamic therapy[J].Chest,2005,128(5):3269-3275.
[54]WANG S,BROMLEY E,XU L,et al.Talaporfin sodium[J].Expert Opinion on Pharmacotherapy,2010,11(1):133-140.
[55]KATO H,FURUKAWA K,SATO M,et al.Phase Ⅱ clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung[J].Lung Cancer(Amsterdam,Netherlands),2003,42(1):103-111.
[56]OKUNAKA T,KATO H,TSUTSUI H,et al.Photodynamic therapy for peripheral lung cancer[J].Lung Cancer(Amsterdam,Netherlands),2004,43(1):77-82.
[57]PASS HI,TEMECK BK,KRANDA K,et al.Phase Ⅲ randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma[J].Annals of Surgical Oncology,1997,4(8):628-633.
[58]FANG J,NAKAMURA H,MAEDA H.The EPR effect:Unique features of tumor blood vessels for drug delivery,factors involved,and limitations and augmentation of the effect[J].Advanced Drug Delivery Reviews,2011,63(3):136-151.

Memo

Memo:
天津市科技支撑计划重点项目(编号:20YFZCSY00570);首都卫生发展科研专项(编号:2022-1-4041);中国医学科学院医学与健康科技创新工程(编号:2021-I2M-1-015)
Last Update: 2024-11-01