|Table of Contents|

Advances in immunotherapy and molecular imaging of B-cell maturation antigen in multiple myeloma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 23
Page:
4517-4521
Research Field:
Publishing date:

Info

Title:
Advances in immunotherapy and molecular imaging of B-cell maturation antigen in multiple myeloma
Author(s):
SONG LeleYANG YihanKANG Lei
Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China.
Keywords:
multiple myelomaB cell maturation antigenpositron-emission tomographyimmunotherapy
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2024.23.015
Abstract:
Multiple myeloma (MM) is a hematologic malignancy characterized by the abnormal proliferation of clonal plasma cells in the bone marrow,which secrete monoclonal immunoglobulins that subsequently damage target organs.The B cell maturation antigen (BCMA) is highly expressed in malignant plasma cells but is absent in most normal cells,being limited to plasma cells,some mature B cells,and CD34+ stem cells.Consequently,BCMA is considered an ideal target for both the diagnosis and treatment of MM.This paper reviews the molecular mechanisms of BCMA in MM,along with the advancements in targeted immunotherapy and BCMA-targeted molecular imaging probes.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.82171970);国家自然科学基金面上项目(编号:82171970);北京市杰出青年科学基金项目(编号:JQ21025);北京市科学技术委员会首都临床特色应用研究项目(编号:Z221100007422027)
Last Update: 2024-11-01