|Table of Contents|

Analysis of different factors on the target margin of esophageal cancer conventional segmentation—The exploration based on real data

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 23
Page:
4482-4488
Research Field:
Publishing date:

Info

Title:
Analysis of different factors on the target margin of esophageal cancer conventional segmentation—The exploration based on real data
Author(s):
ZHAO Yu; ZHU Gengqiang; ZHENG Yongtai; LIU Chao; ZHAO Ruiao; GE Yandong; WAN Bao; ZHANG Yanxin; ZHANG Wei; HUAN Fukui; LIANG Bin; WANG Hongkai
National Cancer Center/National Clinical Research Center for Cancer/Department of Radiation Oncology,Cancer Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,China.
Keywords:
esophageal cancer; CBCT; setup error; body mass index; margin
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.23.010
Abstract:
Objective:The different factors influencing the setup errors of patients with esophageal cancer conventional segmentation were analyzed by using airborne kilovoltage computed tomography (CBCT) of Elekta medical linear accelerator，so as to provide a basis for the boundary of clinical target volume.Methods:159 patients from January 2020 to September 2023 in our cancer hospital radiotherapy center were selected in this study for data analysis of the whole course of treatment.The errors of 3 directions including LAT,LNG and VRT were recorded.The overall setup errors of patients were calculated,and the influences of body mass index (BMI),whether the patients had received surgical treatment,and the classification of different primary tumor sites on the corresponding setup errors of non-surgical patients were explored.Using the Margin formula to analyze the data.Results:The positioning errors of the three directions were as follows:LAT(0.03±0.23) cm,LNG(0.06±0.31) cm,VRT (0.02±0.23) cm.There were significant differences in positioning errors of vertical direction (Z) for patients with different BMI ranges(P=0.000).So,the vertical direction (Z) of BMI<24 kg/m2 patients and BMI≥24 kg/m2 patients were (0.01±0.24) cm and (0.07±0.22) cm.whether the patients had received surgical treatment or not has significant difference in the lateral direction,so the positioning error of lateral direction of non-surgical and surgical patients are （0.04±0.23） cm and（0.02±0.20） cm,respectively.However,in the non-surgical group,patients with cervical or thoracic esophageal cancer had significant difference in the positioning errors of the lateral direction (X) and the vertical direction (Z)(PLAT=0.041,PVRT≈0.000).They were (0.08±0.27) cm and (0.03±0.23) cm in the lateral direction,as well as （0.18±0.23） cm and （0.05±0.24） cm in the vertical direction.According to the analysis of ICRU50 and ICRU62 reports,the target margins are LAT=0.50 mm,LNG=0.74 mm and VRT=0.57 mm.Conclusion:In order to make radiotherapy more accurate for patients with esophageal cancer,the clinical target margin should be considered according to the range of the patient's body mass index (BMI),and the surgery types.For non-surgical patients,the target margin should be taken into account according to the different primary tumor sites.

References:

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Memo

Memo:
National Natural Science Foundation of China（No.12205374）;国家自然科学基金（编号：12205374）；北京市自然科学基金（编号：1232033）；中国癌症基金会北京希望马拉松专项基金（编号：LC2021B23）；中国医学科学院医学与健康科技创新工程“网络化放射治疗计划设计方法研究”（编号：2022-I2M-C&T-B-079）；中国癌症基金会北京希望马拉松专项基金“放射性肺炎预测系统研究”（编号：LC2021B15）
Last Update: 2024-11-01