|Table of Contents|

Clinical effect of cervical conization combined with ternary fusion protein in the treatment of high cervical lesions complicated with high-risk human papillomavirus infection

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 23
Page:
4463-4468
Research Field:
Publishing date:

Info

Title:
Clinical effect of cervical conization combined with ternary fusion protein in the treatment of high cervical lesions complicated with high-risk human papillomavirus infection
Author(s):
ZHANG Junqin; LI Jie; ZHAO Jing; TIAN Fei; YAN Ping
Hebei Provincial People's Hospital,Hebei Shijiazhuang 050051,China.
Keywords:
cervical conization; ternary fusion protein; high cervical lesions; high-risk human papillomavirus infection
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.23.007
Abstract:
Objective:To investigate the clinical effect of cervical conization combined with ternary fusion protein(MSIK) in the treatment of high-grade cervical lesions(HSIL) complicated with high-risk human papillomavirus(HR-HPV) infection.Methods:A total of 186 patients with HSIL admitted to our hospital from August 2019 to July 2021 were selected and randomly divided into MSIK group(n=93) and control group(n=93) by the odd-even method.Both groups were treated with cervical conization.In the control group,human interferon α-2β non-menstrual vaginal effervescent capsule,once every other day,10 times/course,and 3 courses were shared.In MSIK group,non-menstrual vaginal insertion of MSIK was performed for 14 days/course,a total of 3 course.HR-HPV negative conversion rate and TCT abnormality rate were compared between the two groups at different time points before and after treatment.The changes of clinical symptom score before and after treatment and adverse reactions during treatment were compared between the two groups.The cure rate and recurrence rate were compared between the two groups.Results:The negative conversion rate of HR-HPV in the two groups increased during the follow-up period,and the negative conversion rate of HR-HPV in the two groups at 9 and 12 months of follow-up was higher than that at 3 months of follow-up(P＜0.05).The negative conversion rate of HR-HPV in MSIK group was higher than that in control group at 3,6,9,and 12 months of follow-up(P＜0.05).After 3,6,9 and 12 months of follow-up,HR-HPV TCT abnormality rate in the two groups was significantly lower than that before treatment,and that in the MSIK group was lower than that in the control group(P＜0.05).After treatment,the clinical symptom scores of the two groups were lower than those before treatment,and the MSIK group was lower than that before treatment(P＜0.05).The incidence of adverse reactions during MSIK treatment was 3.23%,which was lower than 10.75% in the control group(P＜0.05).The cure rate of MSIK group was 97.85%,which was higher than 81.72% of control group(P＜0.05).After 12 months of follow-up,there was no recurrence in the MSIK group,and the recurrence rate was significantly different from that in the control group(P＜0.05).Conclusion:Cervical conization combined with MSIK in the treatment of HSIL complicated with HR-HPV infection can effectively reduce the viral load of HR-HPV,improve the negative conversion rate,and the treatment effect is exact,the recurrence rate is low,the clinical acceptance is worthy of clinical promotion.

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Memo

Memo:
2021年河北省医学科技计划项目(编号:20210333)
Last Update: 2024-11-01