|Table of Contents|

Expression of miR-1 in tissues and cells of esophageal squamous cell carcinoma and its corrlation with clinicopathological features of patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 23
Page:
4459-4462
Research Field:
Publishing date:

Info

Title:
Expression of miR-1 in tissues and cells of esophageal squamous cell carcinoma and its corrlation with clinicopathological features of patients
Author(s):
YAO Li; ZUO Weichen; GOU Siqi; CHENG Zhengyi; WANG Juanhong
Department of Pathology,Xi'an No.3 Hospital,the Affiliated Hospital of Northwest University,Shaanxi Xi'an 710018,China.
Keywords:
esophageal squamous cell carcinoma; miR-1; SYBR green quantitative PCR
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.23.006
Abstract:
Objective:To determine the expression profiles of miR-1 in esophageal squamous cell carcinoma（ESCC） and the clinical significance of the downregulation of miR-1 in primary ESCC.Methods:The expression profiles of miR-1 in 64 pairs of ESCC tissues and 5 ESCC cell lines were analyzed by reverse transcription PCR and SYBR green quantitative PCR.The differences in the expression level of miR-1 and the clinicopathological characteristics were statistically analyzed by SPSS,t-test and ANOVA test.Results:Among all the samples,90.6%(58/64) of the ESCC tissue samples showed a 2-fold lower expression of miR-1 than that in normal tissues.And miR-1 was significantly downregulated in 5 ESCC cell lines.The results revealed that the downregulation of miR-1 significantly correlated with tumor invasion and advanced clinical stage,while no significant correlation with gender,age,tumor size and degree of differentiation.Conclusion:The expression of miR-1 in ESCC is downregulated and significantly correlated with the depth of tumor invasion and clinical stage.These findings suggest that miR-1 play important roles in the development and progression of ESCC which provides a basic for further reseach on the molecular mechanism of ESCC.

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Memo

Memo:
陕西省重点研发计划项目（编号：2024SF-YBXM-115）
Last Update: 2024-11-01