|Table of Contents|

Current status of evaluation techniques for radiation esophagitis induced by tumor radiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 22
Page:
4391-4395
Research Field:
Publishing date:

Info

Title:
Current status of evaluation techniques for radiation esophagitis induced by tumor radiotherapy
Author(s):
DONG Juancong; CHENG Jiao; WANG Chao; LIU Hongyan
China Institute for Radiation Protection，Shanxi Taiyuan 030006，China．
Keywords:
radiation esophagitis; radiation therapy; biological molecules; evaluation index
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2024.22.030
Abstract:
Tumor radiotherapy has entered the era of precision radiotherapy.With the rapid development of molecular biology technology,the use of biomarkers to evaluate the adverse effects of radiotherapy can provide support for the individualized precision radiotherapy.Radiation esophagitis is easy to be induced during radiotherapy for chest tumors such as lung cancer and esophageal cancer,and thus limit radiotherapy dose or even interrupt radiotherapy plan.Based on literature research,this paper summarizes the current research status of the evaluation technology of biomolecular-based radiation esophagitis,and it could provide reference for the research of individualized precision radiotherapy for tumors.

References:

［1］ 申文江，王绿化.放射治疗损伤［M］.北京：中国医药科技出版社，2001：116. SHEN WJ,WANG LH.Radiotherapy injury［M］.Beijing：China Medical Science and Technology Press，2001：116.
［2］ QIU JJ,KE DM,LIN HC,et al.Using inflammatory indexes and clinical parameters to predict radiation esophagitis in patients with small-cell lung cancer undergoing chemoradiotherapy［J］.Front Oncol,2022,12:898653.
［3］ 许莹莹,朱卫国,王万伟,等.三维适形放疗联合替吉奥同步化疗治疗老年食管癌的疗效及放射性损伤研究［J］.中外医疗,2020,39(36):1-3. XU YY,ZHU WG,WANG WW,et al.Study on the efficacy and radiation damage of three -dimensional conformal radiotherapy combined with Tiggio concurrent chemotherapy in the treatment of elderly esophageal cancer［J］.China & Foreign Medica Treatment,2020,39(36):1-3.
［4］ YU YL,ZHENG HY,LIU LY,et al.Predicting severe radiation esophagitis in patients with locally advanced esophageal squamous cell carcinoma receiving definitive chemoradiotherapy:Construction and validation of a model based in the clinical and dosimetric parameters as well as inflammatory indexes［J］.Front Oncol,2021,11:687035.
［5］ 曹晓云，武霞，杨美伦.重组人IL-11联合营养支持防治食管癌患者放射性食管炎提高其生活质量的作用［J］.实用医药杂志,2019,36(07):604-607,614. CAO XY，WU X，YANG ML.The effect of recombinant human interleukin-11 combined with nutritional support on radiation-induced esophagitis and quality of life in patients with esophageal cancer［J］.Practical Journal of Medicine & Pharmacy,2019,36(07):604-607,614.
［6］ 杨玖，刘志远，朱诺，等.RhGM-CSF 预防非小细胞肺癌放疗所致急性放射性食管炎的效果观察［J］.海军医学杂志,2023,44(03):296-300. YANG J,LIU ZY,ZHU N,et al.Observation on the effects of rhGM-CSF in prevention of acute radiotherapy-induced esophagitis in treatment of NSCLC［J］.Journal of Navy Medicine,2023,44 (03):296-300.
［7］ CHANG SC,LAI YC,HUNG JC,et al.Oral glutamine supplements reduce concurrent chemoradiotherapy-induced esophagitis in patients with advanced non-small cell lung cancer［J］.Medicine (Baltimore),2019,98(8):e14463.
［8］ 董玉梅，魏世鸿，郭丽云，等.口腔溃疡防护剂对食管癌患者放射性食管炎的疗效观察［J］.甘肃医药,2021,40(08):673-675,681. DONG YM,WEI SH,GUO LY,et al.Observation of the effect of oral ulcer protective agent on radiation esophagitis in patients with esophageal cancer［J］.Gansu Medical Journal,2021,40(08):673-675,681.
［9］ 魏天怡，李志刚，谷宁,等.李志刚教授治疗食管癌的中医临证经验［J］.中国中西医结合消化杂志,2024,32(05):440-443,449. WEI TY，LI ZG，GU N,et al.Professor LI Zhigang's clinical experience in the treatment of esophageal cancer［J］.Chin J Integr Trad West Med Dig,2024,32(05):440-443,449.
［10］ 常远，洪梅.预测食管癌患者放疗后放射性食管炎风险列线图模型的建立［J］.肿瘤学杂志,2022,28(03):212-218. CHANG Y,HONG M.Establishment of prediction model for risk of radiation esophagitis in patients with esophageal cancer after radiotherapy［J］.Journal of Chinese Oncology,2022,28(03):212-218.
［11］ 杨从容，王军，袁双虎.放射性食管炎的预防与治疗临床实践指南［J］.中华肿瘤防治杂志,2023,30(06):324-332. YANG CR,WANG J,YUAN SH.Clinical practice guidelines for the prevention and treatment of radiation-induced esophagitis［J］.Chinese Journal of Cancer Prevention and Treatment,2023,30(06):324-332.
［12］ VOICHITA BA,BENJAMIN L,MATTHEW W,et al.Treatment-related acute esophagitis for patients with locoregionally advanced non-small cell lung cancer treated with involved-field radiotherapy and concurrent chemotherapy［J］.Am J Clin Oncol,2014,37(5):433-437.
［13］ 杜文静，顾晓斌，高献书，等.食管鳞癌诱导化疗联合调强放疗治疗模式探讨及预后分析［J］.中华放射医学与防护杂志,2019,39(12):920-925. DU WJ,GU XB,GAO XS,et al.Discussion on the treatment model and prognostic analysis of esophageal squamous cell carcinoma treated with induction chemotherapy combined with intensity-modulated radiation therapy［J］.Chinese Journal of Radiological Medicine and Protection,2019,39(12):920-925.
［14］ 迪丽达尔·斯地克，才层，叶建蔚，等．化疗联合调强放疗治疗食管癌的疗效及不良反应评价［J］.癌症进展,2020,18(07):687-689. DI SDK,CAI C,YE JW,et al.Efficacy and adverse reactions of chemotherapy combined with intensity modulated radiation therapy for esophageal cancer［J］.Oncology Progress,2020,18(07):687-689.
［15］ NINOMIYA K,YOKOYAMA T,HOTTA K,et al.A randomized trial of sodium alginate prevention of radiation－induced esophagitis in patients with locally advanced NSCLC receiving concurrent chemoradiotherapy:OLCSG1401［J］.Support Care Cance,2021,29(9):5237-5244.
［16］ DONG J,ZHANG WC,ZHANG T,et al.Baseline nutritional status could be a predictor for radiation esophagitis in esophageal cancer patients undergoing radiotherapy［J］.Ann Transl Med,2020,8(18):1148.
［17］ LOPEZ GUERRA JL,GOMEZ D,WEI QY,et al.Association between single nucleotide polymorphisms of the transforming growth factor beta1 gene and the risk of severe radiation esophagitis in patients with lung cancer［J］.Radiother Oncol,2012,105(3):299-304.
［18］ 黎思苑.MLR、NLR及纤维蛋白原对接受同步放化疗的老年食管鳞癌患者的预后价值分析［D］.苏州：苏州大学，2021:24-25. LI SY.Study on the prognostic values of MLR、NLR and plasma fibrinogen for survival in esophageal squamous cell cancer patients with concurrent chemoradiotherapy［D］.Suzhou:Soochow University,2021:24-25.
［19］ KIM KS,JEON SU,LEE CJ,et al.Radiation-induced esophagitis in vivo and in vitro reveals that epidermal growth factor is a potential candidate for therapeutic intervention strategy［J］.Int J Radiat Oncol Biol Phys,2016,95(3):1032-1041.
［20］ WANG SL,CAMPBELL J,STENMARK MH,et al.A model combining age,equivalent uniform dose and IL-8 may predict radiation esophagitis in patients with non-small cell lung cancer［J］.Radiother Oncol,2018,126(3):506-510.
［21］ YAO J,ZHANG JK,WANG JL,et al.Transcriptome profiling unveils a critical role of IL-17 signaling-mediated inflammation in radiation-induced esophageal injury in rats［J］.Dose Response,2022,20(2):15593258221104609.
［22］ KITAMURA H,TANIGAWA T,KUZUMOTO T,et al.Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis:Possible involvement of plasmacytoid dendritic cells［J］.Life Sci,2022,289:120215.
［23］ VON REIBNITZ D,YORKE ED,OH JH,et al.Predictive modeling of thoracic radiotherapy toxicity and the potential role of serum alpha-2-macroglobulin［J］.Front Oncol,2020,10:1395.
［24］ 杨焱，潘巍，孙新臣.局部晚期食管癌同步放化疗后急性放射性食管炎与血清C反应蛋白的相关性研究［J］.现代医学,2014,42(02):158-160. YANG Y,PAN W,SUN XC.Radiation esophagitis and serum C-reactive protein in patients with local advanced esophagus cancer treated by concurrent chemo-radiotherapy:a correlational study［J］.Modern Medical Journal,2014,42(02):158-160.
［25］ SUN ZQ,LI JH,LIN M,et al.An RNA-seq-based expression profiling of radiation-induced esophageal injury in a rat model［J］.Dose Response,2019,17(2):1559325819843373.
［26］ 张福鹏，赵晓燕，郝淑兰，等.基于TGF-β1/p38MAPK/FN信号通路的放射性食管炎发病机制的研究［J］.肿瘤防治研究,2020,47(11):823-827 ZHANG FB,ZHAO XY,HAO SL,et al.Pathogenesis of radioactive esophagitis based on TGF-β1/p38MAPK/FN signaling pathway［J］.Cancer Research on Prevention and Treatment,2020,47(11):823-827
［27］ 王丽娟，路军章，李明伟，等.复方竹叶石膏颗粒对家兔急性放射性食管炎COX-2与MMP-2 mRNA及蛋白表达的影响［J］.解放军医药杂志,2017,29(05):5-8. WANG LJ，LU JZ，LI MW，et al.Effects of compound Zhuye Shigao Granule on mRNA and protein expressions of COX-2 and MMP-2 in treatment of rabbits with radiation esophagitis［J］.Medical & Pharmaceutical Journal of Chinese People's Liberation Army,2017,29(05):5-8.
［28］ 宋长亮.金银花水煎液对放射性食管炎患者血管内皮糖萼标志物水平的影响［J］.现代肿瘤医学,2020,28(24):4271-4276. SONG CL.Effect of honeysuckle decoction on vascular endothelial glycocalyx markers in patients with radiation esophagitis［J］.Modern Oncology,2020,28(24):4271-4276.
［29］ ZHANG L,YANG M,BI N,et al.Association of TGF-β1 and XPD polymorphisms with severe acute radiation-induced esophageal toxicity in locally advanced lung cancer patients treated with radiotherapy［J］.Radiother Oncol,2010,97(1):19-25.
［30］ DELGADO B,ENGUIX-RIEGO MV,FERNANDEZ DE BOBADILLA JC,et al.Association of single nucleotide polymorphisms at HSPB1 rs7459185 and TGFB1 rs11466353 with radiation esophagitis in lung cancer［J］.Radiother Oncol,2019,135:161-169.
［31］ AGUADO-BARRERA ME,MARTINEZ-CALVO L,FENANDEZ-TAJES J,et al.Validation of polymorphisms associated with the risk of radiation-induced oesophagitis in an independent cohort of non-small-cell lung cancer patients［J］.Cancers (Basel),2021,13(6):1447.
［32］ 张萌，章文成，杜忠礼，等.硫酸类肝素蛋白多糖基因遗传变异与食管鳞癌放疗患者放射性食管炎发生风险的相关性［J］.中华肿瘤杂志,2015,6:422-426. ZHANG M,ZHANG WC,DU ZL,et al.Genetic variation in SDC2 is associated with the risk of radiation esophagitis in patients with esophageal squamous cell carcinoma receiving radiotherapy［J］.Chinese Journal of Oncology,2015,6:422-426.
［33］ LOPEZ GUERRA JL,WEI QY,YUAN LX,et al.Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy［J］.Radiother Oncol,2011,101(2):271-277.
［34］ DENG YL,TANG DR,HOU PF,et al.Dysbiosis of gut microbiota in patients with esophageal cancer［J］.Microb Pathog,2021,150:104709.
［35］ LIN MQ,WU YH,JUN YJ,et al.Gut microbiota characteristics are associated with severity of acute radiation-induced esophagitis［J］.Front Microbiol,2022,13:883650.
［36］ 杨磊，梁惠，刘阳.中晚期食管癌患者放射治疗前体重指数与放射性食管炎发生的相关性分析［J］.肿瘤综合治疗电子杂志,2023,9(02):161-165. YANG L，LIAG H,LIU Y.Correlation between body mass index before radiotherapy and radiation esophagitis in patients with advanced esophageal cancer［J］.Journal of Multidisciplinary Cancer Management (Electronic Version),2023,9(02):161-165.
［37］ 王菁，杨瑞虹，李杰.血清蛋白指纹图谱预测放射性食管炎的初步研究［J］.山西卫生健康职业学院学报,2022,32(04):12-14. WANG J,YANG RH,LI J.Preliminary study on the prediction of radiation esophagitis by serum protein fingerprint［J］.Journal of Shanxi Health Vocational College,2022,32(04):12-14.
［38］ XU T,LIAO ZX,O' ERILLY MS,et al.Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer［J］.Radiother Oncol,2014,113(3):379-384.
［39］ DI MARTINO MT,ARBITRIO M,CARACCIOLO D,et al.miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases:A systematic review［J］.Mol Ther Nucleic Acids,2022,27:1191-1224.

Memo

Memo:
山西省基础研究计划青年科学研究项目（编号：202103021223454,202103021222406）
Last Update: 1900-01-01