|Table of Contents|

Tumor-associated macrophages and colorectal cancer:Research progress from mechanism to treatment

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 22
Page:
4366-4372
Research Field:
Publishing date:

Info

Title:
Tumor-associated macrophages and colorectal cancer:Research progress from mechanism to treatment
Author(s):
LU Hengzhe1; MO Zhongcheng2; QIU Yuan1; YU Zongchao1; YAN Jie3; LIU Longfei1
1.Department of Gastrointestinal Surgery,the Affiliated Nanhua Hospital,University of South China,Hunan Hengyang 421002,China；2.Department of Histology and Embryology,School of Basic Medicine,Guilin Medical University,Guangxi Guilin 541199,China；3.Department of Gynecology and Obstetrics,the Affiliated Liuzhou People's Hospital,Guilin Medical University,Guangxi Liuzhou 545000,China.
Keywords:
colorectal cancer; tumor-associated macrophages; tumor microenvironment; polarization; treatment strategies
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2024.22.026
Abstract:
Colorectal cancer (CRC) is a malignant tumor that occurs in the digestive system,and it ranks at the top of the list in terms of incidence and mortality worldwide.The tumor microenvironment (TME) mediates the progression of CRC,and tumor-associated macrophages (TAMs) serve as a major component of the TME,regulating multiple processes such as the occurrence,proliferation,migration,invasion,and drug resistance of CRC.This review summarizes the origin,polarization,and phenotypic regulation of TAMs,as well as the progress in understanding their regulatory mechanism and therapeutic strategies in CRC.Although further exploration is needed in the clinical research of TAMs in CRC,the therapeutic significance of TAMs in CRC has been established,providing insights into the understanding of the relationship between TAMs and CRC.

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湖南省自然科学基金项目（编号：2020JJ4552）
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