«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 22

Page:

4296-4304

Research Field:

Publishing date:

Info

Title:

The expression of PFKP in lung adenocarcinoma tissue and its relationship with prognosis

Author(s):

TIAN Zhe¹; 2; CEN Lilan³; WEI Feng¹; 2; DENG Junhua¹; 2; QIN Chunyan¹; 2; WANG Zhibo¹; 2; XU Shiyang¹; 2; DONG Jue¹; 2; HUANG Yulan¹; 2; JIANG Yujie¹; 2

1.Department of Pulmonary and Critical Care Medicine,the Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Baise 533000,China;2.Life Science and Clinical Medicine Research Center,the Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Baise 533000,China;3.Guangxi Academy of Medical Sciences,Department of Infectious Disease,the People's Hospital of Guangxi Zhuang Autonomous Region,Guangxi Nanning 530021,China.

Keywords:

adenocarcinoma of lung; PFKP; tumor staging; immunotherapy; tumor microenvironment

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2024.22.013

Abstract:

Objective:To investigate the pivotal role of platelet-type phosphofructokinase£¨PFKP£© in adenocarcinoma of lung£¨LUAD).Methods£ºPFKP expression in LUAD tissues and adjacent normal tissues was assessed utilizing The Cancer Genome Atlas (TCGA) database.In addition,immunohistochemistry was conducted on clinical samples of LUAD tissues and adjacent normal tissues to evaluate PFKP expression.The TCGA database was further exploited to investigate PFKP expression and its correlation with LUAD prognosis and immune infiltration.Results:Our findings unveiled upregulated PFKP expression in LUAD tissues,established an association with clinical pathological features £¨AJCC stage and TNM stage£© and poor prognosis.Kaplan-Meier survival analysis and ROC curve analysis substantiated these observations by demonstrating that patients with high PFKP expression exhibited shorter median overall survival than those with low expression.Notably,PFKP expression displayed heightened predictive value for 1-year,3-year,and 5-year survival predictions.Enrichment analysis disclosed the involvement of PFKP's biological functions in anti-tumor drug metabolism processes.Moreover,PFKP exhibited close associations with the tumor microenvironment and immune therapy.Consequently,our study identified several clinical drugs and inhibitors that exhibited increased sensitivity in LUAD patients with high PFKP expression.Conclusion:PFKP's critical role in the onset and progression of LUAD and its potential as a drug therapy target make its significance in both research and treatment.

References:

£Û1£Ý XIA C,DONG X,LI H,et al.Cancer statistics in China and United States,2022:profiles,trends,and determinants £ÛJ£Ý.Chinese Medical Journal,2022,135(5):584-590.
£Û2£Ý KOLB T,M¦aLLER S,M¦ZLLER P,et al.Molecular heterogeneity in histomorphologic subtypes of lung adenocarcinoma represents a challenge for treatment decision£ÛJ£Ý.Neoplasia£¬2024,49:100955.
£Û3£Ý SHEN J,JIN Z,LV H,et al.PFKP is highly expressed in lung cancer and regulates glucose metabolism £ÛJ£Ý.Cellular Oncology (Dordrecht),2020,43(4):617-629.
£Û4£Ý VORA S,MIRANDA AF,HERNANDEZ E,et al.Regional assignment of the human gene for platelet-type phosphofructokinase (PFKP) to chromosome 10p:novel use of polyspecific rodent antisera to localize human enzyme genes £ÛJ£Ý.Human Genetics,1983,63(4):374-379.
£Û5£Ý SHA X,WANG K,WANG F,et al.Silencing PFKP restrains the stemness of hepatocellular carcinoma cells £ÛJ£Ý.Experimental Cell Research,2021,407(1):112789.
£Û6£Ý LEE JH,LIU R,LI J,et al.Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis £ÛJ£Ý.Nature Communications,2017,8(1):949.
£Û7£Ý CHEN C,ZHANG X.Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth £ÛJ£Ý.Clinical & Translational Oncology,2023,25(7):2183-2191.
£Û8£Ý CHEN G,LIU H,ZHANG Y,et al.Silencing PFKP inhibits starvation-induced autophagy,glycolysis,and epithelial mesenchymal transition in oral squamous cell carcinoma £ÛJ£Ý.Experimental Cell Research,2018,370(1):46-57.
£Û9£Ý CHEN J,ZOU L,LU G,et al.PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation £ÛJ£Ý.Cell Discovery,2022,8(1):52.
£Û10£Ý UMAR SM,KASHYAP A,KAHOL S,et al.Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer £ÛJ£Ý.Experimental Cell Research,2020,396(1):112282.
£Û11£Ý LU TJ,YANG YF,CHENG CF,et al.Phosphofructokinase platelet overexpression accelerated colorectal cancer cell growth and motility £ÛJ£Ý.Journal of Cancer,2023,14(6):943-951.
£Û12£Ý LIM JS,SHI Y,PARK SH,et al.Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth £ÛJ£Ý.Cell Death & Disease,2022,13(11):1002.
£Û13£Ý KOBAYASHI H,TAKASE S,NISHIMURA H,et al.RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells£ÛJ£Ý.Cancer Sci,2023,114(4):1663-1671.
£Û14£Ý LANG L,CHEMMALAKUZHY R,SHAY C,et al.PFKP signaling at a glance:An emerging mediator of cancer cell metabolism £ÛJ£Ý.Advances in Experimental Medicine and Biology,2019,1134:243-258.
£Û15£Ý WANG F,LI L,ZHANG Z.Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non-small cell lung cancer £ÛJ£Ý.Molecular Medicine Reports,2021,23(1):74.
£Û16£Ý INAISHI T,SHIBATA M,ICHIKAWA T,et al.Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer £ÛJ£Ý.Oncology Reports,2022,47(1):9.
£Û17£Ý LUGADE A,MORAN J,GERBER S,et al.Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor£ÛJ£Ý.J Immunol,2005,174(12):7516-7523.
£Û18£Ý LU W,ZHANG Y,MCDONALD DO,et al.Dual proteolytic pathways govern glycolysis and immune competence£ÛJ£Ý.Cell,2014,159(7):1578-1590.
£Û19£Ý LI FL,LIU JP,BAO RX,et al.Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis £ÛJ£Ý.Nature Communications,2018,9(1):508.
£Û20£Ý GUO W,ZHANG Y,CHEN T,et al.Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model £ÛJ£Ý.Journal of Cancer Research and Clinical Oncology,2011,137(1):65-72.
£Û21£Ý WANG SY,WEI YH,SHIEH DB,et al.2-deoxy-D-glucose can complement doxorubicin and sorafenib to suppress the growth of papillary thyroid carcinoma cells £ÛJ£Ý.PLoS One,2015,10(7):e0130959.
£Û22£Ý PEPE F,PAGOTTO S,SOLIMAN S,et al.Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells £ÛJ£Ý.Oncogenesis,2017,6(5):e328.
£Û23£Ý HAGENBUCHNER J,KUZNETSOV AV,OBEXER P,et al.BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery £ÛJ£Ý.Oncogene,2013,32(40):4748-4757.
£Û24£Ý XU R,YUAN LS,GAN YQ,et al.Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked£ÛJ£Ý.Free Radic Biol Med,2024,212:117-132.

Memo

Memo:

National Natural Science Foundation of China(No.81860021£©£»¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð£¨±àºÅ£º81860021£©£»¹ãÎ÷×ÔÈ»¿Æѧ»ù½ð£¨±àºÅ£º2021GXNSFAA325003£©£»¹ãÎ÷׳×å×ÔÖÎÇøÎÀÉúºÍ¼Æ»®Î¯Ô±»á×Գﾭ·Ñ¿ÆÑпÎÌ⣨±àºÅ£ºZ20180216£©£»¹ãÎ÷¸ßУÖÐÇàÄê½Ìʦ¿ÆÑлù´¡ÄÜÁ¦ÌáÉýÏîÄ¿£¨±àºÅ£º2023KY0573£©£»¹ãÎ÷Ê¡°ÙÉ«ÊÐÇøÓò¶à·¢²¡ÁªºÏרÏî¼Æ»®£¨±àºÅ£º°Ù¿Æ×Ö£Û2022£Ý41ºÅ£©£»¹ãÎ÷Ê¡°ÙÉ«ÊпÆѧÑо¿Óë¼¼Êõ¿ª·¢ÏîÄ¿£¨±àºÅ£º°Ù¿Æ20232086£©

Common functions

Last Update: 1900-01-01