|Table of Contents|

Chinese expert consensus on the diagnosis and treatment of cervical cancer in the elderly

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 22
Page:
4213-4219
Research Field:
Publishing date:

Info

Title:
Chinese expert consensus on the diagnosis and treatment of cervical cancer in the elderly
Author(s):
YI Tianjin1LI Kemin1YIN Rutie1ZHOU Shengtao1GAO Guolan1KONG Weimin2GAO Yunong3
Gynecology Branch of Chinese Society of Gerontology and Geriatrics (1.West China Second Hospital,Sichuan University,Sichuan Chengdu 610016,China;2.Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University Beijing Maternal and Child Health Hospital,Beijing 100006,China;3.Peking University Cancer Hospital,Beijing 100142,China.)
Keywords:
cervical cancerelderly womenChinatreatmentexpert consensus
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.22.001
Abstract:
Cervical cancer is one of the most common malignant tumors in women.The proportion of cervical cancer patients aged 60 and above in China is 24.8%.Compared with younger patients,elderly women with newly diagnosed cervical cancer are diagnosed later,and are less likely to undergo radical surgery during treatment,who also have a lower rate of completing standardized radical synchronous chemoradiotherapy,and have a worse overall survival rate.Currently,there is a lack of guidances on the diagnosis and treatment of elderly patients with cervical cancer.In order to standardize the diagnosis and treatment of cervical cancer in elderly Chinese women,the Gynecology Branch of the Chinese Society of Gerontology and Geriatrics organized experts to form the following Chinese expert consensus based on evidence-based medicine and combined with clinical diagnosis and treatment experience,aiming to provide assistance for the diagnosis and treatment decision-making of elderly cervical cancer.

References:

[1]QI J,LI M,WANG L,et al.National and subnational trends in cancer burden in China,2005-20:an analysis of national mortality surveillance data[J].Lancet Public Health,2023,8(12):e943-e955.
[2]BRUNI L,ALBERO G,SERRANO B,et al.Human papollomavirus and related diseases report[J/OL].ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre),2023,1-307[2024-5-1].https://hpvcentre.net/statistics/reports/XWX.pdf.
[3]DIVER EJ,HINCHCLIFF EM,GOCKLEY AA,et al.Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old[J] .J Geriatr Oncol,2018,9(5):516-519.
[4]DALE W,KLEPIN HD,WILLIAMS GR,et al.Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy:ASCO guideline update[J] .J Clin Oncol,2023,41(26):4293-4312.
[5]WILDIERS H,HEEREEN P,PUTS M,et al.International society of geriatric oncology consensus on geriatric assessment in older patients with cancer[J] .J Clin Oncol,2014,32(24):2595-2603.
[6]MICHAAN N,PARK SY,LIM MC.Comprehensive geriatric assessment is correlated to overall survival among gynaecologic oncology patients[J] .Jpn J Clin Oncol,2020,50(3):276-281.
[7]CAILLET P,CANOUI-POITRINE F,VOYRIOT J,et al.Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer:ELCAPA study[J] .J Clin Oncol,2011,29(27):3636-3642.
[8]NISHIO S,MIKAMI Y,TOKUNAGA H,et al.Analysis of gastric-type mucinous carcinoma of the uterine cervix-An aggressive tumor with a poor prognosis:A multi-institutional study[J] .Gynecol Oncol,2019,153(1):13-19.
[9]COHEN JG,KAPP DS,SHIN JY,et al.Small cell carcinoma of the cervix:treatment and survival outcomes of 188 patients[J] .Am J Obstet Gynecol,2010,203(4):347.e1-347.e3476.
[10]BHALA N,AOKI D,SHARMA DN,et al.Cancer of the cervix uteri:2021 update[J] .Int J Gynaecol Obstet,2021,155 Suppl 1(Suppl 1):28-44.
[11]MASSAD LS,PERKINS RB,NARESH A,et al.Colposcopy Standards:Guidelines for endocervical curettage at colposcopy[J] .J Low Genit Tract Dis,2023,27(1):97-101.
[12]MATTRA OM,SAMY A,SHEHATA M,et al.The efficacy of local anesthetics in pain relief during colposcopic-guided biopsy:A systematic review and meta-analysis of randomized controlled trials[J] .Eur J Obstet Gynecol Reprod Biol,2019,237:189-197.
[13]DIVER EJ,HINCHCLIFF EM,GOCKLEY AA,et al.Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old[J] .J Geriatr Oncol,2018,9(5):516-519.
[14]EGGEMANN H,IGNATOV T,GEYKEN CH,et al.Management of elderly women with cervical cancer[J] .J Cancer Res Clin Oncol,2018,144(5):961-967.
[15]MANGANARO L,LAKHMAN Y,BHARWANI N,et al.Staging,recurrence and follow-up of uterine cervical cancer using MRI:Updated guidelines of the European Society of Urogenital Radiology after revised FIGO staging 2018[J] .Eur Radiol,2021,31(10):7802-7816.
[16]SALA E,ROCKALLAG,FREEMAN SJ,et al.The added role of MR imaging in treatment stratification of patients with gynecologic malignancies:What the radiologist needs toknow[J] .Radiologv,2013,266(3):717-740.
[17]ATRI M,ZHANG Z,DEHDASHTI F,et al.Utility of PET-CT to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer:Results of ACRIN6671/GOG0233 trial[J] .Gynecol Oncol,2016,142(3):413-419.
[18]OLAWAIYE AB,BAKER TP,WASHINGON MK,et al.The new (Version 9) American Joint Committee on Cancer tumor,node,metastasis staging for cervical cancer[J] .CA Cancer J Clin,2021,71(4):287-298.
[19]BHATLA N,BEREK JS,CUELLO FREDES M,et al.Revised FIGO staging for carcinoma of the cervix uteri[J] .Int J Gynaecol Obstet,2019,145(1):129-135.
[20]ALBER A,LEE A,ALBRIGHT R,et al.Impact of age on receipt of curative treatment for cervical cancer:an analysis of patterns of care and survival in a large,national cohort[J] .J Geriatr Oncol,2019,10(3):465-474.
[21]DARLIN L,BORGFELDT C,WIDEN E,et al.Elderly women above screening age diagnosed with cervical cancer have a worse prognosis[J] .Anticancer Res,2014,34(9):5147-5151.
[22]GRORGE EM,TERGAS AI,ANANTH CV,et al.Safety and tolerance of radical hysterectomy for cervical cancer in the elderly[J].Gynecol Oncol,2014,134(1):36-41.
[23]MOUSAVI A,KARIMI ZARCHI M,GILANI MM,et al.Radical hysterectomy in the elderly[J] .World J Surg Oncol,2008,6:38.
[24]MOTHES AR,KATHE A,CEPRAGA I,et al.Robotic-assisted gynecological surgery in older patients - a comparative cohort study of perioperative outcomes[J].Geburtshilfe Frauenheilkd,2023,83(4):437-445.
[25]ALOISI A,TSEN JH,SANADADI S,et al.Is robotic-assisted surgery safe in the elderly population? an analysis of gynecologic procedures in patients ≥65 years old[J].Ann Surg Oncol,2019,26(1):244-251.
[26]RAFFONE A,TRAVAGLINO A,RAIMINEDO D,et al.Laparotomic versus robotic surgery in elderly patients with endometrial cancer:a systematic review and meta-analysis[J].Int J Gynaecol Obstet,2022,157(1):1-10.
[27]RAMIREZ PT,FRUMOVITZ M,PAREJA R,et al.Minimally invasive versus abdominal radical hysterectomy for cervical cancer[J] .N Engl J Med,2018,379(20):1895-1904.
[28]ZHOU Hui,LIU Junjun,LUO Min,et al.Interpretation of the 2022 NCCN clinical practice guidelines for cervical cancer (1st edition)[J] .Chinese Journal of Practical Gynecology and Obstetrics,2021,37(12):1220-1226.
[29]KIM SI,CHO JH,SEOL A,et al.Comparison of survival outcomes between minimally invasive surgery and conventional open surgery for radical hysterectomy as primary treatment in patients with stage IB1-IIA2 cervical cancer[J] .Gynecol Oncol,2019,153(1):3-12.
[30]CHEN C,LIU P,NI Y,et al.Laparoscopic versus abdominal radical hysterectomy for stage IB1 cervical cancer patients with tumor size≤2 cm:a case-matched control study[J] .Int J Clin Oncol,2020,25(5):937-947.
[31]Chinese Medical Doctor Association Society of Obstetricians and Gynecologists Gynecologic Oncology Committee (Study Group).Chinese expert consensus on the diagnosis and management of cervical adenocarcinoma in situ (2021 edition)[J].Chinese Journal of Practical Gynecology and Obstetrics,2021,37(12):1209-1213.
[32]SCHMELER KM,PAREJA R,LOPEZ BLANCO A,et al.ConCerv:a prospective trial of conservative surgery for low-risk early-stage cervical cancer[J] .Int J Gynecol Cancer,2021,31(10):1317-1325.
[33]PLANTE M,KWO JS,FERGUSON S,et al.Simple versus radical hysterectomy in women with low-risk cervical cancer[J] .N Engl J Med,2024,390(9):819-829.
[34]MATHEVET P,LECURU F,UZAN C,et al.Sentinel lymph node biopsy and morbidity outcomes in early cervical cancer:Results of a multicentre randomised trial (SENTICOL-2)[J] .Eur J Cancer,2021,148:307-315.
[35]Chinese Society of Research Hospitals Obstetrics and Gynecology Committee.Chinese expert consensus on the clinical application of sentinel lymph node biopsy for cervical cancer[J] .Chinese Journal of Oncology,2021,43(10):981-988.
[36]HATA M.Radiation therapy for elderly patients with uterine cervical cancer:feasibility of curative treatment[J] .Int J Gynecol Cancer,2019,29(3):622-629.
[37]BARBEN J,KAMGA AM,DABAKUYO-YONLI TS,et al.Cervical cancer in older women:Does age matter[J] Maturitas,2022,158:40-46.
[38]KISSEL M,RAMBEAU A,ACHKAR S,et al.Challenges and advances in cervix cancer treatment in elder women[J] .Cancer Treat Rev,2020,84:101976.
[39]GEORGIA HALKETT,MORIRA O'COM NONNOR,MICHAEL JEFFORD,et al.RT Prepare:a radiation therapist-delivered intervention reduces psychological distress in women with breast cancer referred for radiotherapy[J] .Br J Cancer,2018,118(12):1549-1558.
[40]KOKKA F,BRYANT A,OLAITANI A,et al.Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer[J] .Cochrane Database Syst Rev,2022,8(8):CD010260.
[41]CHAKRABARTI M,NORDIN A,KHODABOCUS J.Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer[J] .Cochrane Database Syst Rev,2022,9(9):CD012246.
[42]MICHAEL XIANG,ELIZABETH A KIDD.Benefit of cisplatin with definitive radiotherapy in older women with cervical cancer[J] .J Natl Compr Canc Netw,2019,17(8):969-975.
[43]NIU GL,WANG H,REN YJ,et al.Penpulimab and anlotinib in an elderly patient with recurrent cervical cancer:a case report and literature review[J] .Immunotherapy,2023,15(12):905-912.
[44]ZHOU Hui,LIU Junjun,LUO Min,et al.Interpretation of the updated version of the 2024 NCCN clinical practice guidelines for cervical cancer (1st Edition) [J] .Chinese Journal of Practical Gynecology and Obstetrics,2023,39(11):1119-1121.

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Last Update: 1900-01-01