|Table of Contents|

Research progress of kidney cancer treatment drugs based on ferroptosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 21
Page:
4167-4172
Research Field:
Publishing date:

Info

Title:
Research progress of kidney cancer treatment drugs based on ferroptosis
Author(s):
YU Lingyan12YANG Xinyi12YANG Chen2DU Jing2ZHANG Juanyu3TONG Xiangmin234
1.The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Zhejiang Hangzhou 310053,China;2.Zhejiang Provincial People's Hospital(Hangzhou Medical College Affiliated People's Hospital) Laboratory Center,Zhejiang Hangzhou 310014,China;3.West Lake University Affiliated Hangzhou First People's Hospital,Zhejiang Hangzhou 310006,China;4.Department of Hematology,Lishui Central Hospital,Zhejiang Lishui 323000,China.
Keywords:
ferroptosiskidney cancerherbal medicinenatural compoundnanomaterials
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2024.21.028
Abstract:
Kidney cancer is a common malignant tumor of the urinary system,which is a serious threat to human health.Surgery is an effective strategy for the treatment of early-stage kidney cancer.However,due to the poor treatment effect of advanced renal cancer and the susceptibility of chemotherapy to drug resistance,there is an urgent need to develop other potential therapeutic strategies.Ferroptosis is a newly defined form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides,which plays a critical role in tumor progression and drug resistance.Recent studies have shown that ferroptosis is involved in the occurrence and development of kidney cancer.Ferroptosis related genes can induce cell apoptosis,and can be used as potential biomarkers for early diagnosis of renal cancer and participate in drug resistance of renal cancer chemotherapy.With the continuous improvement of the mechanism of ferroptosis,drugs targeting ferroptosis for the treatment of renal cancer are emerging in an endless stream.Based on the theoretical basis of the occurrence of ferroptosis,this paper reviewes drug-induced ferroptosis in renal cancer cells from the aspects of herbal medicine,natural compounds,drug resistance mechanisms,and nanomaterials,hoping to provide a new strategy for the treatment of renal cancer with ferroptosis related drugs.

References:

[1]BRAY FREDDIE,LAVERSANNE MATHIEU,SUNG HYUNA,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA:A Cancer Journal for Clinicians,2024,74(3):229-263.
[2] BUKAVINA LAURA,BENSALAH KARIM,BRAY FREDDIE,et al.Epidemiology of renal cell carcinoma:2022 ipdate[J].European Urology,2022,82(5):529-542.
[3] YAN XQ,YE MJ,ZOU Q,et al.Toripalimab plus axitinib versus sunitinib as first-line treatment for advanced renal cell carcinoma:RENOTORCH,a randomized,open-label,phase III study[J].Annals of Oncology,2024,35(2):190-199.
[4] VIOLA J CHEN,HERNANDEZ-MEZA,PRASHASTI AGRAWAL,et al.Time on therapy for at least three months correlates with overall survival in metastatic renal cell carcinoma[J].Cancers,2019,11(7):1000.
[5] FENG Q,YANG Y,REN KDet al.Broadening horizons:the multifaceted functions of ferroptosis in kidney diseases[J].International Journal of Biological Sciences,2023,19(12):3726-3743.
[6] CHEN X,LI JB,KANG R,et al.Ferroptosis:machinery and regulation[J].Autophagy,2021,17(9):2054-2081.
[7] ZHANG YY,NI ZHI J,ELAM ELNUR,et al.Juglone,a novel activator of ferroptosis,induces cell death in endometrial carcinoma Ishikawa cells[J].Food & Function,2021,12(11):4947-4959.
[8] BASULI DEBARGHA,TESFAY LIA,DENG ZHIYONG,et al.Iron addiction:A novel therapeutic target in ovarian cancer[J].Oncogene,2017,36(29):4089-4099.
[9] ELING NILS,REUTER LUKAS,HAZIN JOHN,et al.Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells[J].Oncoscience,2015,2(5):517-532.
[10] GREENSHIELDS AL,SHEPHERD TG,HOSKIN DW.Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate:Impact of artesunate on ovarian cancer[J].Molecular Carcinogenesis,2017,56(1):75-93.
[11] LEI GUANG,ZHUANG LI,GAN BOYI.Targeting ferroptosis as a vulnerability in cancer[J].Nature Reviews Cancer,2022,22(7):381-396.
[12] FENG HUIZHONG,SCHORPP KENJI,JIN JENNY,et al.Transferrin receptor is a specific ferroptosis marker[J].Cell Reports,2020,30(10):3411-3423.e7.
[13] LIANG DEGUANG,MINIKES ALEXANDER M,JIANG XUEJUN.Ferroptosis at the intersection of lipid metabolism and cellular signaling[J].Molecular Cell,2022,82(12):2215-2227.
[14] LE POPE,SJ DIXON.Regulation of ferroptosis by lipid metabolism[J].Trends in Cell Biology,2023,33(12):1077-1087.
[15] LIU Y,WAN YC,JIANG Y,et al.GPX4:The hub of lipid oxidation,ferroptosis,disease and treatment[J].Biochimica Et Biophysica Acta Reviews on Cancer,2023,1878(3):188890.
[16] DOLL SEBASTIAN,FREITAS FP,SHAH RON,et al.FSP1 is a glutathione-independent ferroptosis suppressor[J].Nature,2019,575(7784):693-698.
[17] MAO C,LIU XG,ZHANG YL,et al.DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer[J].Nature,2021,593(7860):586-590.
[18] KRAFT VN,BEZJIAN CT,PFEIFFER SUSANNE,et al.GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling[J].ACS Central Science,2020,6(1):41-53.
[19] ZEITLER LEONIE,FIORE ALESSANDRA,MEYER CLAUDIA,et al.Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism[J].eLife,2021,10:e64806.
[20] YANG WAN SEOK,SRIRAMARATNAM ROHITHA,WELSCH MATTHEW E,et al.Regulation of ferroptotic cancer cell death by GPX4[J].Cell,2014,156(1):317-331.
[21] LI JH,ZHENG SJ,FAN YM,et al.Emerging significance and therapeutic targets of ferroptosis:a potential avenue for human kidney diseases[J].Cell Death & Disease,2023,14(9):628.
[22] ZHANG YL,SHI JJ,LIU XG,et al.BAP1 links metabolic regulation of ferroptosis to tumour suppression[J].Nature Cell Biology,2018,20(10):1181-1192.
[23] AFFAR EL BACHIR,CARBONE MICHELE.BAP1 regulates different mechanisms of cell death[J].Cell Death & Disease,2018,9(12):1151.
[24] JIANG LE,KON NING,LI TONGYUAN,et al.Ferroptosis as a p53-mediated activity during tumour suppression[J].Nature,2015,520(7545):57-62.
[25] ZHANG LONG,HOBEIKA CHARBEL S,KHABIBULLIN DAMIR,et al.Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11[J].Proceedings of the National Academy of Sciences,2022,119(28):e2122840119.
[26] KERINS MJ,MILLIGAN JOHN,WOHLSCHLEGEL JA,et al.Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction[J].Cancer Science,2018,109(9):2757-2766.
[27] YANG WEN HSUAN,DING CHIEN KUANG CORNELIA,SUN TIANAI,et al.The Hippo pathway effector TAZ regulates ferroptosis in renal cell carcinoma[J].Cell Reports,2019,28(10):2501-2508.e4.
[28] LAI YC,ZENG T,LIANG XF,et al.Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy[J].Cancer Cell International,2019,19:221.
[29] YU R,ZHOU YF,SHI SF,et al.Icariside II induces ferroptosis in renal cell carcinoma cells by regulating the miR-324-3p/GPX4 axis[J].Phytomedicine,2022,102:154182.
[30] HUANG Z,GAN S,ZHUANG X,et al.Artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy[J].Cells,2022,11(16):2472.
[31] MA ZC,CHEN WJ,LIU YD,et al.Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy[J].Autophagy,2024,20(3):541-556.
[32] EFFERTH THOMAS.From ancient herb to modern drug:Artemisia annua and artemisinin for cancer therapy[J].Seminars in Cancer Biology,2017,46:65-83.
[33] LEE HYE MIN,MOON AREE.Amygdalin regulates apoptosis and adhesion in Hs578T triple-negative breast cancer cells[J].Biomolecules & Therapeutics,2016,24(1):62-66.
[34] MARKOWITSCH SASCHA D,SCHUPP PATRICIA,LAUCKNER JULIA,et al.Artesunate inhibits growth of sunitinib-resistant renal cell carcinoma cells through cell cycle arrest and induction of ferroptosis[J].Cancers,2020,12(11):3150.
[35] KANG RUI,KROEMER GUIDO,TANG DAOLIN.The tumor suppressor protein p53 and the ferroptosis network[J].Free Radical Biology & Medicine,2019,133:162-168.
[36] XIAO HX,XU XZ,DU LY,et al.Lycorine and organ protection:Review of its potential effects and molecular mechanisms[J].Phytomedicine,2022,104:154266.
[37] QI J,MENG M,LIU J,et al.Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes[J].Biochemical Pharmacology,2023,217:115833.
[38] LI Z,ZHOU Q,LIU X,et al.Lycorine upregulates the expression of RMB10,promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells[J].International Journal of Molecular Medicine,2022,50(6):145.
[39] DU Y,ZHAO HC,ZHU HC,et al.Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells[J].Oncology Letters,2021,22(5):781.
[40] HAN SHANGTING,LIN FANGYOU,QI YUCHENG,et al.HO-1 contributes to luteolin-triggered ferroptosis in clear cell renal cell carcinoma via increasing the labile iron pool and promoting lipid peroxidation[J].Oxidative Medicine and Cellular Longevity,2022,2022:1-26.
[41] CHEN YH,WU JYUNXUE,YANG SHUN FA,et al.Synergistic combination of luteolin and asiatic acid on cervical cancer in vitro and in vivo[J].Cancers,2023,15(2):548.
[42] E JUENGEL,A THOMAS,J RUTZ,et al.Amygdalin inhibits the growth of renal cell carcinoma cells in vitro[J].International Journal of Molecular Medicine,2016,37(2):526-532.
[43] J RUTZ,S MAXEINER,E JUENGEL,et al.Growth and proliferation of renal cell carcinoma cells is blocked by low curcumin concentrations combined with visible light irradiation[J].International Journal of Molecular Sciences,2019,20(6):1464.
[44] PB GUPTA,TT ONDER,G JIANG,et al.Identification of selective inhibitors of cancer stem cells by high-throughput screening[J].Cell,2009,138(4):645-659.
[45] ZHOU J,LIU S,WANG Y,et al.Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma[J].Molecular Cancer,2019,18(1):159.
[46] WANG ZY,ZHANG H,CHENG Q.PDIA4:The basic characteristics,functions and its potential connection with cancer[J].Biomedicine & Pharmacotherapy,2020,122:109688.
[47] ZOU YL,PALTE MICHAEL J,DEIK AMY A,et al.A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis[J].Nature Communications,2019,10(1):1617.
[48] B ESCUDIER,T EISEN,WM STADLER,et al.Sorafenib in advanced clear-cell renal-cell carcinoma[J].The New England Journal of Jedicine,2007,356(2):125-134.
[49] DIXON SCOTT J,PATEL DARPAN N,WELSCH MATTHEW,et al.Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis[J].eLife,2014,3:e02523.
[50] CHANG K,CHEN Y,ZHANG X,et al.DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma[J].Cancer Research,2023,83(23):3940-3955.
[51] TANG Z,LI J,SHEN Q,et al.Contribution of upregulated dipeptidyl peptidase 9(DPP9) in promoting tumoregenicity,metastasis and the prediction of poor prognosis in non-small cell lung cancer(NSCLC)[J].International Journal of Cancer,2017,140(7):1620-1632.
[52] GAO R,KALATHUR R,COTO-LLERENA M,et al.YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis[J].EMBO Molecular Medicine,2021,13(12):e14351.
[53] PARK JEE SOO,KOO KYO CHUL,CHUNG DOO YONG,et al.Visceral adiposity as a significant predictor of sunitinib-induced dose-limiting toxicities and survival in patients with metastatic clear cell renal cell carcinoma[J].Cancers,2020,12(12):3602.
[54] WANG Q,GAO S,SHOU Y,et al.AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis[J].International Journal of Biological Sciences,2023,19(4):1266-1283.
[55] GAN B.ACSL4,PUFA,and ferroptosis:new arsenal in anti-tumor immunity[J].Signal Transduction and Targeted Therapy,2022,7(1):128.
[56] YANGYUN WANG,GUOWEI SHI,SHUFEN SHI,et al.Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma[J].Gene,2022,809:145992.
[57] HAO JF,CHEN QG,FENG YM,et al.Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway[J].Cell Death & Disease,2023,14(4):247.
[58] S JAISWAL,SR AYYANNAN.Anticancer potential of small-molecule inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase[J].Chem Med Chem,2021,16(14):1-17.
[59] D FIORE,MC PROTO,S PISANTI,et al.Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells[J].Cancer Biology & Therapy,2016,17(8):849-858.
[60] N VAN EGMOND,VM STRAUB,M VAN DER STELT.Targeting endocannabinoid signaling:FAAH and MAG lipase inhibitors[J].Annual Review of Pharmacology and Toxicology,2021,6:1-23.
[61] NI WENJUN,LI YONGXIANG,LIANG LINGXIA,et al.Tumor microenvironment-responsive nanodrug for clear-cell renal cell carcinoma therapy via triggering waterfall-like cascade ferroptosis[J].Journal of Biomedical Nanotechnology,2022,18(2):327-342.
[62] LI FY,LU JX,KONG XQ,et al.Dynamic nanoparticle assemblies for biomedical applications[J].Advanced Materials,2017,29(14):1605897.
[63] LIU B,HU F,ZHANG JF,et al.A biomimetic coordination nanoplatform for controlled encapsulation and delivery of drug-gene combinations[J].Angewandte Chemie(International Ed.in English),2019,58(26):8804-8808.
[64] LIU JJ,WU M,PAN YT,et al.Biodegradable nanoscale coordination polymers for targeted tumor combination therapy with oxidative stress amplification[J].Advanced Functional Materials,2020,30(13):1908865.
[65] LIU Z,LI T,HAN F,et al.A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF[J].Biomaterials Science,2019,7(9):1-10.
[66] HUANG Y,JC HSU,H KOO,et al.Repurposing ferumoxytol:Diagnostic and therapeutic applications of an FDA-approved nanoparticle[J].Theranostics,2022,12(2):796-816.
[67] LIANG H,WU X,ZHAO G,et al.Renal clearable ultrasmall single-crystal Fe nanoparticles for highly selective and effective ferroptosis therapy and immunotherapy[J].Journal of the American Chemical Society,2021,143(38):15812-15823.

Memo

Memo:
National Natural Science Foundation of China(No.82102938);国家自然科学基金(编号:82102938)
Last Update: 2024-09-30