|Table of Contents|

Research progress of DDR1 in hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 20
Page:
3994-3998
Research Field:
Publishing date:

Info

Title:
Research progress of DDR1 in hepatocellular carcinoma
Author(s):
GAO Chun12JIANG Jingjing12ZHENG Xiaofeng3YU Xiaohui1ZHANG Jiucong1
1Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of PLA,Gansu Lanzhou 730050,China;2First School of Clinical Medical,Gansu University of Chinese Medicine,Gansu Lanzhou 730000,China;3Department of Gastroenterology,Lanzhou University Second Hospital,Gansu Lanzhou 730030,China.
Keywords:
DDR1ligandshepatocellular carcinomaaction mechanismtreatment targets
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2024.20.034
Abstract:
Hepatocellular carcinoma (HCC) is one of the highly heterogeneous and invasive malignant tumors of the digestive system,posing a serious threat to the health of people worldwide.Liver transplantation is one of the radical treatment strategies for HCC,but the high recurrence and metastasis rates after surgery still pose challenges to the long-term survival of patients.Therefore,elucidating the potential pathogenesis of HCC is crucial for developing new and effective diagnostic biomarkers and treatment methods.Discoidin domain receptor (DDR) belongs to the transmembrane receptor tyrosine kinase family and plays an important regulatory role in many diseases,including tumors.DDR has two members:DDR1 and DDR2.The role of DDR1 in various tumors has been widely studied,and many researchers have identified it as a powerful candidate target for developing tumor therapy inhibitor drugs.However,its role and mechanism in HCC are still unclear.In this article,we provide a brief overview of the research progress of DDR1 in HCC,in order to provide new insights for the treatment of HCC as much as possible.

References:

[1] BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263.
[2] TUMEN D,HEUMANN P,GULOW K,et al.Pathogenesis and current treatment strategies of hepatocellular carcinoma[J].Biomedicines,2022,10(12):3202.
[3] SOLIMANDO AG,SUMMA S,VACCA A,et al.Cancer-associated angiogenesis:the endothelial cell as a checkpoint for immunological patrolling[J].Cancers,2020,12(11):3380.
[4] LEE YT,TAN YJ,OON CE.Molecular targeted therapy:treating cancer with specificity[J].Eur J Pharmacol,2018,834:188-196.
[5] ITOH Y.Discoidin domain receptors:microenvironment sensors that promote cellular migration and invasion[J].Cell Adh Migr,2018,12(4):378-385.
[6] ELKAMHAWY A,LU Q,NADA H,et al.The journey of DDR1 and DDR2 kinase inhibitors as rising stars in the fight against cancer[J].Int J Mol Sci,2021,22:6535.
[7] MEHTA V,CHANDER H,MUNSHI A.Complex roles of discoidin domain receptor tyrosine kinases in cancer[J].Clin Transl Oncol,2021,23(8):1497-1510.
[8] GONG H,XU HM,ZHANG DK.Focusing on discoidin domain receptors in premalignant and malignant liver diseases[J].Front Oncol,2023,13:1123638.
[9] HENRIET E,SALA M,ABOU HA,et al.Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer[J].Cell Adh Migr,2018,12(4):363-377.
[10] GAO Y,ZHOU J,LI J.Discoidin domain receptors orchestrate cancer progression:a focus on cancer therapies[J].Cancer Sci,2021,112(3):962-969.
[11] TAKAI K,DRAIN AP,LAWSON DA,et al.Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers[J].Genes Dev,2018,32(3-4):244-257.
[12] DENNY WA,FLANAGAN JU.Inhibitors of discoidin domain receptor (DDR) kinases for cancer and inflammation[J].Biomolecules,2021,11(11):1671.
[13] MCDONELL LM,KERNOHAN KD,BOYCOTT KM,et al.Receptor tyrosine kinase mutations in developmental syndromes and cancer:two sides of the same coin[J].Hum Mol Genet,2015,24(R1):R60-R66.
[14] BUTTI R,DAS S,GUNASEKARAN VP,et al.Receptor tyrosine kinases (RTKs) in breast cancer:signaling,therapeutic implications and challenges[J].Mol Cancer,2018,17(1):34.
[15] NEBEN CL,LO M,JURA N,et al.Feedback regulation of RTK signaling in development[J].Dev Biol,2019,447(1):71-89.
[16] FANTAUZZO KA,SORIANO P.Receptor tyrosine kinase signaling:regulating neural crest development one phosphate at a time[J].Curr Top Dev Biol,2015,111:135-182.
[17] KROHN JB,HUTCHESON JD,MARTINEZ-MARTINEZ E,et al.Discoidin domain receptor-1 regulates calcific extracellular vesicle release in vascular smooth muscle cell fibrocalcific response via transforming growth factor-β signaling[J].Arterioscler Thromb Vasc Biol,2016,36(3):525-533.
[18] JUSKAITE V,CORCORAN DS,LEITINGER B.Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers[J].Elife,2017,6:e25716.
[19] SHRIVASTAVA A,RADZIEJEWSKI C,CAMPBELL E,et al.An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors[J].Mol Cell,1997,1(1):25-34.
[20] GAO H,CHAKRABORTY G,ZHANG Z,et al.Multi-organ site metastatic reactivation mediated by non-canonical discoidin domain receptor 1 signaling[J].Cell,2016,166(1):47-62.
[21] LEITINGER B.Molecular analysis of collagen binding by the human discoidin domain receptors,DDR1 and DDR2.Identification of collagen binding sites in DDR2[J].J Biol Chem,2003,278(19):16761-16769.
[22] BELLA J,HULMES DJ.Fibrillar collagens[J].Subcell Biochem,2017,82:457-490.
[23] POSEY KL,COUSTRY F,HECHT JT.Cartilage oligomeric matrix protein:COMPopathies and beyond[J].Matrix Biol,2018,71-72:161-173.
[24] PENG DH,UNGEWISS C,TONG P,et al.ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis[J].Oncogene,2017,36(14):1925-1938.
[25] VENNIN C,CHIN VT,WARREN SC,et al.Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression,sensitivity to chemotherapy,and metastasis[J].Sci Transl Med,2017,9(384):eaai8504.
[26] ZHENG X,LIU W,XIANG J,et al.Collagen Ⅰ promotes hepatocellular carcinoma cell proliferation by regulating integrin β1/FAK signaling pathway in nonalcoholic fatty liver[J].Oncotarget,2017,8(56):95586-95595.
[27] DEJMEK J,DIB K,JONSSON M,et al.Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion[J].Int J Cancer,2003,103(3):344-351.
[28] SHINTANI Y,FUKUMOTO Y,CHAIKA N,et al.Collagen Ⅰ-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1[J].J Cell Biol,2008,180(6):1277-1289.
[29] FERRI N,CARRAGHER NO,RAINES EW.Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling:potential implications in atherosclerosis and lymphangioleiomyomatosis[J].Am J Pathol,2004,164(5):1575-1585.
[30] LU P,TAKAI K,WEAVER VM,et al.Extracellular matrix degradation and remodeling in development and disease[J].Cold Spring Harb Perspect Biol,2011,3(12):a005058.
[31] ROMAYOR I,BADIOLA I,OLASO E.Inhibition of DDR1 reduces invasive features of human A375 melanoma,HT29 colon carcinoma and SK-HEP hepatoma cells[J].Cell Adh Migr,2020,14(1):69-81.
[32] GIANCOTTI FG.Mechanisms governing metastatic dormancy and reactivation[J].Cell,2013,155(4):750-764.
[33] MALEKI EH,BAHRAMI AR,MATIN MM.Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance[J].Genes Dis,2023,11(1):189-204.
[34] PEREZ-GONZALEZ A,BEVANT K,BLANPAIN C.Cancer cell plasticity during tumor progression,metastasis and response to therapy[J].Nat Cancer,2023,4(8):1063-1082.
[35] DI MARTINO JS,NOBRE AR,MONDAL C,et al.A tumor-derived type Ⅲ collagen-rich ECM niche regulates tumor cell dormancy[J].Nat Cancer,2022,3(1):90-107.
[36] GUO Z,XIE Q,WU Y,et al.Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma[J].Cell Oncol (Dordr),2023,46(5):1333-1350.
[37] ORGEL JPRO,MADHURAPANTULA RS.A structural prospective for collagen receptors such as DDR and their binding of the collagen fibril[J].Biochim Biophys Acta Mol Cell Res,2019,1866(11):118478.
[38] TEWARI D,PATNI P,BISHAYEE A,et al.Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer:A novel therapeutic strategy[J].Semin Cancer Biol,2022,80:1-17.
[39] LIU J,XIAO Q,XIAO J,et al.Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities[J].Signal Transduct Target Ther,2022,7(1):3.
[40] WANG J,JIANG YH,YANG PY,et al.Increased collagen type V α2 (COL5A2) in colorectal cancer is associated with poor prognosis and tumor progression[J].Onco Targets Ther,2021,14:2991-3002.
[41] GADIYA M,CHAKRABORTY G.Signaling by discoidin domain receptor 1 in cancer metastasis[J].Cell Adh Migr,2018,12(4):315-323.
[42] LU J,KISHORE U.C1 complex:an adaptable proteolytic module for complement and non-complement functions[J].Front Immunol,2017,8:592.
[43] BULLA R,TRIPODO C,RAMI D,et al.C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation[J].Nat Commun,2016,7:10346.
[44] LEE JH,POUDEL B,KI HH,et al.Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1[J].Sci Rep,2018,8(1):4908.
[45] VEHLOW A,CORDES N.DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy[J].Autophagy,2019,15(8):1487-1488.
[46] HAYUNINGTYAS RA,HAN M,CHOI S,et al.The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2[J].Mol Med,2021,27(1):125.
[47] CANNING P,TAN L,CHU K,et al.Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type Ⅱ kinase inhibitors[J].J Mol Biol,2014,426(13):2457-2470.
[48] MONTENEGRO RC,HOWARTH A,CERONI A,et al.Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib[J].Oncotarget,2020,11(5):535-549.
[49] JEITANY M,LEROY C,TOSTI P,et al.Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer[J].EMBO Mol Med,2018,10:e7918.
[50] RAM R,LORENTE G,NIKOLICH K,et al.Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2[J].J Neurooncol,2006,76(3):239-248.
[51] TAO Y,WANG R,LAI Q,et al.Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma[J].Mol Oncol,2019,13(9):1855-1873.
[52] WANG Q,TANG B,SUN D,et al.Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis[J].Acta Pharm Sin B,2022,12(4):1943-1962.
[53] CHEN DH,LI Q.lncRNA and sorafenib resistance of hepatocellular carcinoma:New advances in molecular mechanisms and therapeutic targets[J].Modern Oncology,2023,31(24):4633-4639.
[54] REN HW,LIU JY,WU LX,et al.Safety and efficacy of camrelizumab combined with thalidomide for advanced hepatocellular carcinoma[J].Modern Oncology,2022,30(12):2201-2204.

Memo

Memo:
甘肃省自然科学基金项目(编号:23JRRA1673,21JR7RA002,22JR5RA1012);中央高校优秀青年团队培育项目(编号:1001451201)
Last Update: 1900-01-01