[1] BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263.
[2] TUMEN D,HEUMANN P,GULOW K,et al.Pathogenesis and current treatment strategies of hepatocellular carcinoma[J].Biomedicines,2022,10(12):3202.
[3] SOLIMANDO AG,SUMMA S,VACCA A,et al.Cancer-associated angiogenesis:the endothelial cell as a checkpoint for immunological patrolling[J].Cancers,2020,12(11):3380.
[4] LEE YT,TAN YJ,OON CE.Molecular targeted therapy:treating cancer with specificity[J].Eur J Pharmacol,2018,834:188-196.
[5] ITOH Y.Discoidin domain receptors:microenvironment sensors that promote cellular migration and invasion[J].Cell Adh Migr,2018,12(4):378-385.
[6] ELKAMHAWY A,LU Q,NADA H,et al.The journey of DDR1 and DDR2 kinase inhibitors as rising stars in the fight against cancer[J].Int J Mol Sci,2021,22:6535.
[7] MEHTA V,CHANDER H,MUNSHI A.Complex roles of discoidin domain receptor tyrosine kinases in cancer[J].Clin Transl Oncol,2021,23(8):1497-1510.
[8] GONG H,XU HM,ZHANG DK.Focusing on discoidin domain receptors in premalignant and malignant liver diseases[J].Front Oncol,2023,13:1123638.
[9] HENRIET E,SALA M,ABOU HA,et al.Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer[J].Cell Adh Migr,2018,12(4):363-377.
[10] GAO Y,ZHOU J,LI J.Discoidin domain receptors orchestrate cancer progression:a focus on cancer therapies[J].Cancer Sci,2021,112(3):962-969.
[11] TAKAI K,DRAIN AP,LAWSON DA,et al.Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers[J].Genes Dev,2018,32(3-4):244-257.
[12] DENNY WA,FLANAGAN JU.Inhibitors of discoidin domain receptor (DDR) kinases for cancer and inflammation[J].Biomolecules,2021,11(11):1671.
[13] MCDONELL LM,KERNOHAN KD,BOYCOTT KM,et al.Receptor tyrosine kinase mutations in developmental syndromes and cancer:two sides of the same coin[J].Hum Mol Genet,2015,24(R1):R60-R66.
[14] BUTTI R,DAS S,GUNASEKARAN VP,et al.Receptor tyrosine kinases (RTKs) in breast cancer:signaling,therapeutic implications and challenges[J].Mol Cancer,2018,17(1):34.
[15] NEBEN CL,LO M,JURA N,et al.Feedback regulation of RTK signaling in development[J].Dev Biol,2019,447(1):71-89.
[16] FANTAUZZO KA,SORIANO P.Receptor tyrosine kinase signaling:regulating neural crest development one phosphate at a time[J].Curr Top Dev Biol,2015,111:135-182.
[17] KROHN JB,HUTCHESON JD,MARTINEZ-MARTINEZ E,et al.Discoidin domain receptor-1 regulates calcific extracellular vesicle release in vascular smooth muscle cell fibrocalcific response via transforming growth factor-β signaling[J].Arterioscler Thromb Vasc Biol,2016,36(3):525-533.
[18] JUSKAITE V,CORCORAN DS,LEITINGER B.Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers[J].Elife,2017,6:e25716.
[19] SHRIVASTAVA A,RADZIEJEWSKI C,CAMPBELL E,et al.An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors[J].Mol Cell,1997,1(1):25-34.
[20] GAO H,CHAKRABORTY G,ZHANG Z,et al.Multi-organ site metastatic reactivation mediated by non-canonical discoidin domain receptor 1 signaling[J].Cell,2016,166(1):47-62.
[21] LEITINGER B.Molecular analysis of collagen binding by the human discoidin domain receptors,DDR1 and DDR2.Identification of collagen binding sites in DDR2[J].J Biol Chem,2003,278(19):16761-16769.
[22] BELLA J,HULMES DJ.Fibrillar collagens[J].Subcell Biochem,2017,82:457-490.
[23] POSEY KL,COUSTRY F,HECHT JT.Cartilage oligomeric matrix protein:COMPopathies and beyond[J].Matrix Biol,2018,71-72:161-173.
[24] PENG DH,UNGEWISS C,TONG P,et al.ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis[J].Oncogene,2017,36(14):1925-1938.
[25] VENNIN C,CHIN VT,WARREN SC,et al.Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression,sensitivity to chemotherapy,and metastasis[J].Sci Transl Med,2017,9(384):eaai8504.
[26] ZHENG X,LIU W,XIANG J,et al.Collagen Ⅰ promotes hepatocellular carcinoma cell proliferation by regulating integrin β1/FAK signaling pathway in nonalcoholic fatty liver[J].Oncotarget,2017,8(56):95586-95595.
[27] DEJMEK J,DIB K,JONSSON M,et al.Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion[J].Int J Cancer,2003,103(3):344-351.
[28] SHINTANI Y,FUKUMOTO Y,CHAIKA N,et al.Collagen Ⅰ-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1[J].J Cell Biol,2008,180(6):1277-1289.
[29] FERRI N,CARRAGHER NO,RAINES EW.Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling:potential implications in atherosclerosis and lymphangioleiomyomatosis[J].Am J Pathol,2004,164(5):1575-1585.
[30] LU P,TAKAI K,WEAVER VM,et al.Extracellular matrix degradation and remodeling in development and disease[J].Cold Spring Harb Perspect Biol,2011,3(12):a005058.
[31] ROMAYOR I,BADIOLA I,OLASO E.Inhibition of DDR1 reduces invasive features of human A375 melanoma,HT29 colon carcinoma and SK-HEP hepatoma cells[J].Cell Adh Migr,2020,14(1):69-81.
[32] GIANCOTTI FG.Mechanisms governing metastatic dormancy and reactivation[J].Cell,2013,155(4):750-764.
[33] MALEKI EH,BAHRAMI AR,MATIN MM.Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance[J].Genes Dis,2023,11(1):189-204.
[34] PEREZ-GONZALEZ A,BEVANT K,BLANPAIN C.Cancer cell plasticity during tumor progression,metastasis and response to therapy[J].Nat Cancer,2023,4(8):1063-1082.
[35] DI MARTINO JS,NOBRE AR,MONDAL C,et al.A tumor-derived type Ⅲ collagen-rich ECM niche regulates tumor cell dormancy[J].Nat Cancer,2022,3(1):90-107.
[36] GUO Z,XIE Q,WU Y,et al.Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma[J].Cell Oncol (Dordr),2023,46(5):1333-1350.
[37] ORGEL JPRO,MADHURAPANTULA RS.A structural prospective for collagen receptors such as DDR and their binding of the collagen fibril[J].Biochim Biophys Acta Mol Cell Res,2019,1866(11):118478.
[38] TEWARI D,PATNI P,BISHAYEE A,et al.Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer:A novel therapeutic strategy[J].Semin Cancer Biol,2022,80:1-17.
[39] LIU J,XIAO Q,XIAO J,et al.Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities[J].Signal Transduct Target Ther,2022,7(1):3.
[40] WANG J,JIANG YH,YANG PY,et al.Increased collagen type V α2 (COL5A2) in colorectal cancer is associated with poor prognosis and tumor progression[J].Onco Targets Ther,2021,14:2991-3002.
[41] GADIYA M,CHAKRABORTY G.Signaling by discoidin domain receptor 1 in cancer metastasis[J].Cell Adh Migr,2018,12(4):315-323.
[42] LU J,KISHORE U.C1 complex:an adaptable proteolytic module for complement and non-complement functions[J].Front Immunol,2017,8:592.
[43] BULLA R,TRIPODO C,RAMI D,et al.C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation[J].Nat Commun,2016,7:10346.
[44] LEE JH,POUDEL B,KI HH,et al.Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1[J].Sci Rep,2018,8(1):4908.
[45] VEHLOW A,CORDES N.DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy[J].Autophagy,2019,15(8):1487-1488.
[46] HAYUNINGTYAS RA,HAN M,CHOI S,et al.The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2[J].Mol Med,2021,27(1):125.
[47] CANNING P,TAN L,CHU K,et al.Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type Ⅱ kinase inhibitors[J].J Mol Biol,2014,426(13):2457-2470.
[48] MONTENEGRO RC,HOWARTH A,CERONI A,et al.Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib[J].Oncotarget,2020,11(5):535-549.
[49] JEITANY M,LEROY C,TOSTI P,et al.Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer[J].EMBO Mol Med,2018,10:e7918.
[50] RAM R,LORENTE G,NIKOLICH K,et al.Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2[J].J Neurooncol,2006,76(3):239-248.
[51] TAO Y,WANG R,LAI Q,et al.Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma[J].Mol Oncol,2019,13(9):1855-1873.
[52] WANG Q,TANG B,SUN D,et al.Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis[J].Acta Pharm Sin B,2022,12(4):1943-1962.
[53] CHEN DH,LI Q.lncRNA and sorafenib resistance of hepatocellular carcinoma:New advances in molecular mechanisms and therapeutic targets[J].Modern Oncology,2023,31(24):4633-4639.
[54] REN HW,LIU JY,WU LX,et al.Safety and efficacy of camrelizumab combined with thalidomide for advanced hepatocellular carcinoma[J].Modern Oncology,2022,30(12):2201-2204.