|Table of Contents|

The expression levels of serum miR-491-3p and miR-412-3p in patients with colorectal cancer and their relationship with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 20
Page:
3896-3900
Research Field:
Publishing date:

Info

Title:
The expression levels of serum miR-491-3p and miR-412-3p in patients with colorectal cancer and their relationship with prognosis
Author(s):
YAN Changlin1; SUN Xingwei2; LIU Yuanwei3
1.Department of Anorectal Surgery,the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712000,China;2.Anorectal Department，Xi'an Traditional Chinese Medicine Hospital,Shaanxi Xi'an 710021,China;3.Department of Oncology,the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712000,China.
Keywords:
colorectal cancer; prognosis; microRNA-491-3p; microRNA-412-3p
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2024.20.014
Abstract:
Objective:To explore the relationship between the expression levels of serum microRNA-491-3p (miR-491-3p) and miR-412-3p and the prognosis of colorectal cancer (CRC) patients and their predictive value.Methods:A total of 110 CRC patients (CRC group) and 98 healthy subjects (control group) were collected as observation objects.The expression levels of serum miR-491-3p and miR-412-3p were detected by qRT-PCR.Aaccording to the follow-up results,CRC patients were divided into survival group (73 cases) and death group (37 cases).Clinical data and serum expression levels of miR-491-3p and miR-412-3p were compared.ROC curve was applied to analyze the predictive value of serum miR-491-3p and miR-412-3p levels in mortality of CRC patients,multivariate Cox regression was applied to analyze factors that affected the prognosis of CRC patients.Results:Compared with the control group,the miR-491-3p expression level in the CRC group was decreased,while the miR-412-3p expression level was increased (P＜0.05).Compared with patients without lymph node metastasis and TNM stage I-II,patients with lymph node metastasis and TNM stage III-IV hada lower miR-491-3p level and a higher miR-412-3p level (P＜0.05).Compared to the survival group,the proportion of patients with lymph node metastasis and TNM stage III-IV in the death group increased,and the expression level of miR-491-3p was decreased,while the expression level of miR-412-3p was increased (P＜0.05).The AUC of miR-491-3p and miR-412-3p levels,and combined in predicting 3-year mortality in CRC patients was 0.842,0.917,and 0.967,respectively.miR-412-3p was an independent risk factor for 3-year mortality in CRC patients,while miR-491-3p was a protective factor (P＜0.05).Conclusion:The expression level of miR-491-3p in serum of CRC patients decreases,while the expression level of miR-412-3p increases,they are related to patients'prognosis,and both have certain predictive value for the 3-year prognosis of CRC patients.

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陕西省重点研发计划（编号：2022SF-369）
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