|Table of Contents|

Expression of LRRC1 in breast cancer tissues and its relationship with TCF7L2,a key transcription factor of the Wnt/β-catenin signaling pathway

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 20
Page:
3868-3874
Research Field:
Publishing date:

Info

Title:
Expression of LRRC1 in breast cancer tissues and its relationship with TCF7L2,a key transcription factor of the Wnt/β-catenin signaling pathway
Author(s):
ZHANG Fangfang1; 2; HAN Yifei1; WANG Jingnan3; ZOU Yan1; LI Na1
1.Department of Pathology,Xinxiang Medical University,Henan Xinxiang 453003,China;2.Department of Pathology,Thrid Affiliated Hospital of Xinxiang Medical University,Henan Xinxiang 453003,China;3.Sanquan College of Xinxiang Medical University,Henan Xinxiang 453003,China.
Keywords:
LRRC1; TCF7L2; breast cancer; clinicopathologic features; diagnostic value
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.20.009
Abstract:
Objective:To investigate the relationship between the expression of leucine-rich repeat-containing protein 1 (LRRC1) and transcription factor 7-like 2 (TCF7L2) and clinicopathological features in breast cancer,and analyze the correlation between the two and their value in breast cancer pathology diagnosis.Methods:UALCAN database to analyze the expression of LRRC1 mRNA and protein in breast cancer and the relationship with clinicopathological characteristics of patients.Kaplan-Meier Plotter database to analyze the effect of LRRC1 expression on the prognosis of breast cancer patients.The Human Protein Atlas (HPA) database analyzes the expression and localization of LRRC1 and TCF7L2 in breast cancer.GEPIA database predicts the correlation between LRRC1 and TCF7L2 expression in breast cancer.Immunohistochemical SP method was used to detect the expression of LRRC1 and TCF7L2 proteins in breast cancer and paracancerous normal breast tissues,to analyze the relationship between LRRC1 and TCF7L2 proteins and the clinicopathological features of breast cancer,and to analyze the correlation between the two using Spearman's analysis.Receiver operating characteristic curve (ROC curve) to assess the value of LRRC1 and TCF7L2 in the pathologic diagnosis of breast cancer.Results:Database analysis showed that the expression of LRRC1 mRNA and protein in breast cancer tissues was significantly higher than that in normal breast tissues (P＜0.05),and its expression level in breast cancer tissues was closely correlated with different lymph node metastasis subgroups and breast cancer molecular typing,and the expression of LRRC1 was significantly different from both overall survival (OS) and progression free survival (PFS) of breast cancer patients (P＜0.05),and there was a significant correlation between the expression levels of LRRC1 and TCF7L2 (P＜0.05).Immunohistochemical results showed that the expression of both LRRC1 and TCF7L2 proteins in breast cancer tissues was significantly higher than that in normal breast tissues adjacent to the cancer (P＜0.05),and the expression of LRRC1 protein was closely correlated with tumor size,stage and lymph node metastasis (all P<0.05),and the expression of TCF7L2 protein was correlated with tumor grade,stage and lymph node metastasis (all P<0.05).Spearman correlation analysis showed that LRRC1 and TCF7L2 expression were positively correlated (r=0.366,P＜0.01).ROC curve showed that the area under curve (AUC) of LRRC1 and TCF7L2 were 0.826 and 0.786,respectively,and that the protein expression of the two was of high diagnostic value of breast cancer.Conclusion:LRRC1 and TCF7L2 are closely related to breast cancer development and prognosis,and the detection of LRRC1 and TCF7L2 is helpful in the pathologic diagnosis of breast cancer.

References:

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Memo

Memo:
河南省教育厅高校重点科研项目（编号：24A310010）；新乡医学院基础医学院科研培育项目（编号：JCYXYKY202017）
Last Update: 1900-01-01