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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 19

Page:

3817-3821

Research Field:

Publishing date:

Info

Title:

Research progress on the role of monocarboxylate transporters 1 and 4 in the occurrence,development and treatment of colorectal cancer

Author(s):

ZHANG Xiao¹; ZHANG Song¹; XU Weitian¹; WANG Haiping²

1.Department of Gastroenterology,General Hospital of Central Theater Command,Hubei Wuhan 430070,China;2.School of Medicine,Jianghan University,Hubei Wuhan 430056,China.

Keywords:

monocarboxylate transporter; lactate; colorectal cancer; tumor immune microenvironment

PACS:

R735.3

DOI:

10.3969/j.issn.1672-4992.2024.19.034

Abstract:

Monocarboxylate transporter 1(MCT1) and MCT4,as pivotal transmembrane transport proteins,play crucial roles in facilitating the passive transmembrane transport of lactate.A multitude of studies have consistently demonstrated the implication of heightened expressions of MCT1 and MCT4 in the onset and progression of colorectal cancer.Lactate undergoes transmembrane transport across the interfaces of tumor cells and the cancer-associated stroma cells,facilitated by MCT1 and MCT4.This process significantly influences the tumor cells and the immune microenvironment within the tumor.Consequently,it contributes substantively to the swift proliferation,invasion,and immune evasion of tumor cells.The elevated expression levels of MCT1 and MCT4 in colorectal cancer underscore their potential as not only clinical prognostic markers but also as promising therapeutic targets.This article aims to furnish a comprehensive review of the investigations into lactate transport mediated by MCT1 and MCT4 in the context of colorectal cancer.

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Memo

Memo:

National Natural Science Foundation of China(No.82200708);¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð(±àºÅ:82200708)£»½­ºº´óѧУ¼¶¿ÆÑÐÏîÄ¿(±àºÅ:2022SXZX27)

Common functions

Last Update: 2024-08-30