|Table of Contents|

Analysis of prognostic factors in 92 pediatric acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 19
Page:
3748-3751
Research Field:
Publishing date:

Info

Title:
Analysis of prognostic factors in 92 pediatric acute myeloid leukemia
Author(s):
PAN Yusu; WANG Wenpeng; MI Xin; XIN Cong; GAO Jizhao
Department of Pediatric Hematology and Oncology,Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221002,China.
Keywords:
children; acute myeloid leukemia; prognostic factors
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2024.19.021
Abstract:
Objective：To investigate the prognostic factors of acute myeloid leukemia (AML) in children.Methods:92 children with acute myeloid leukemia admitted to our hospital from december 2015 to december 2022 were collected and divided into survival group and death group.Their clinical characteristics and influencing factors were retrospectively analyzed.Results:The positive rates of WBC,LDH,SF,bone marrow primitive+naive cells and MRD in the death group were higher than those in the survival group,with statistical significance (P＜0.05).CHE and CD3 in death group were lower than those in survival group,and the difference was statistically significant (P＜0.05).Binary Logistic regression analysis showed that the positive rates of SF and MRD in the death group were higher than those in the survival group,the difference was statistically significant (P＜0.05).Conclusion：WBC,LDH,CHE,SF,MRD,CD3 and bone marrow primitive+naive cells influence the prognosis of pediatric AML,SF and MRD are independent prognostic factors in children with AML.

References:

［1］BARBARA B,FRIDA R,RICCARDO M,et al.Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol［J］.British Journal of Haematology,2017,177(1):116-126.
［2］KAROL SE,GUEGUEN G.Pediatric acute myeloid leukemia - novel approaches［J］.Current Opinion in Hematology,2023,31(2):47-52.
［3］PENGYUN Z,YE C,CHONOGGE Y,et al.Long noncoding RNA small nucleolar RNA host gene 1 is not only overexpressed,but also correlates with increased white blood cell count,deteriorate induction treatment response and poor survival profile in adult acute myeloid leukemia patients［J］.Official journal of Turkish Society of Haematology,2022,39(3):188-195.
［4］PAU M,IGNACIO L,GUILLERMO M,et al.Tumor lysis syndrome in patients with acute myeloid leukemia:identification of risk factors and development of a predictive model［J］.Haematologica,2008,93(1):67-74.
［5］NIKLAS JE,FRIEDRICH S,DESIREE K,et al.Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations［J］.Journal of Hematology Oncology,2022,15(1):60.
［6］COVUT F,GUPATA D,PINOTO R,et al.Comparison of peripheral blast clearance and day 14 bone marrow biopsy in predicting remission status and survival after 7+3 induction in acute myeloid leukemia［J］.Clinical Lymphoma,Myeloma and Leukemia,2018,19(2):73-82.
［7］NGUYEN TH,BACH KQ,VU HQ,et al.Pre-chemotherapy white blood cell depletion by therapeutic leukocytapheresis in leukemia patients:A single-institution experience［J］.Journal of Clinical Apheresis,2020,35(2):117-124.
［8］CHIHYUN C.Analysis of correlation between bone marrow vascular endothelial growth factor per platelet count and blast percentage in hematologic malignancies［J］.Annals of Clinical and Laboratory Science,2023,53(3):469-475.
［9］DAVIDSON Z,QIANGHUA Z,MOJGAN Z,et al.AML with CEBPA mutations:A comparison of ICC and WHO-HAEM5 criteria in patients with 20% or more blasts［J］.Leukemia Research,2023,134:107376.
［10］BUCCISANO F,HOURIGAN CS,WALTER RB.The prognostic significance of measurable (minimal) residual disease in acute myeloid leukemia［J］.Current Hematologic Malignancy Reports,2017,12(6):547-556.
［11］TIONG IS,LOO S.Targeting measurable residual disease (MRD) in Acute myeloid leukemia (AML):Moving beyond prognosticatio［J］.International Journal of Molecular Sciences,2023,24(5):4790.
［12］LUCAS F,HERGOTT CB.Advances in acute myeloid leukemia classification,prognostication and monitoring by flow cytometry［J］.Clinics in Laboratory Medicine,2023,43(3):377-398.
［13］ZHENG Y,PAN L,LI J,et al.Prognostic significance of multiparametric flow cytometry minimal residual disease at two time points after induction in pediatric acute myeloid leukemia［J］.BMC Cancer,2024,24(1):46.
［14］SCHUMACHER K,HAENSCCH W,ROEFZAAD C,et al.Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas［J］.Cancer Research,2001,61(10):3932-3936.
［15］LE DR,TAUSSIG DC,RAMSAY AG,et al.Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts［J］.Blood,2009,114(18):3909-3916.
［16］黄方,郝思国.急性髓系白血病患者外周血T淋巴细胞亚群的水平变化及临床意义［J］.第二军医大学学报,2020,41(5):546-550. HUANG F,HAO SG.Levels changes and clinical significance of T lymphocyte subsets in the peripheral blood of patients with acute myeloid leukemia［J］.Journal of the Second Military Medical University,2020,41 (5):546-550.
［17］JANA I,SOPHIA G,ANNABEL S,et al.AML:high serum ferritin at initial diagnosis has a negative impact on long-term survival［J］.Leukemia Lymphoma,2019,60(1):69-77.
［18］HOLE PS,ZABKIEWICZ J,MUNJE C,et al.Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling［J］.Blood,2013,122(19):3322-3330.
［19］TACHIBANA T,ANDOU T,TANAKA M,et al.Clinical significance of serum ferritin at diagnosis in patients with acute myeloid leukemia:A YACHT multicenter retrospective study［J］.Clinical Lymphoma Myeloma and Leukemia,2018,18(6):415-421.
［20］VLADIMIR J,SANDRA R,GORDANA K.The Actual role of LDH as tumor marker,biochemical and clinical aspects［J］.Advances in Experimental Medicine and Biology,2015,86:7115-7124.
［21］KHAN AA,ALLEMAILEM KS,ALHUMAYDHI FA,et al.The biochemical and clinical perspectives of lactate dehydrogenase:An enzyme of active metabolism［J］.Endocrine,Metabolic Immune Disorders Drug Targets,2020,20(6):855-868.
［22］HAILIANG R,JIE M,LE C,et al.Serum cholinesterase may independently predict prognosis in non-small-cell lung cancer［J］.BMC Cancer,2022,22(1):93.
［23］KIMURA S,SORIA F,D'ANDREA D,et al.Prognostic value of serum cholinesterase in non-muscle invasive bladder cancer［J］.Clinical Genitourinary Cancer,2018,16(6):e1123.
［24］YASUHIRO T,KOICHIRO H,SHU T,et al.The impact of low serum cholinesterase levels on survival in patients with colorectal cancer［J］.International Journal of Colorectal Disease,2022,37(4):869-877.
［25］王桂云,陈兆红,孙立荣.急性白血病患儿血清胆碱酯酶水平的变化［J］.实用临床医药杂志,2016,20(3):182-183. WANG GY,CHEN ZH,SUN LR.Changes in serum cholinesterase levels in children with acute leukemia［J］.Practical Clinical Medicine,2016,20 (3):182-183.
［26］BEJANYAN N,WEISDORF JD,LOGAN RB,et al.Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation:A center for international blood and marrow transplant research study［J］.Biology of Blood and Marrow Transplantation,2015,21(3):454-459.
［27］ZARNRGAR LS,CALDWELL KJ,RUBNITZ JE.Relapsed acute myeloid leukemia in children and adolescents:current treatment options and future strategies［J］.Leukemia,2022,36(8):1951-1960.
［28］赵明一,李嘉华,江华.儿童急性髓系白血病造血干细胞移植后复发的预防和治疗［J］.临床儿科杂志,2023,41(03):167-174. ZHAO MY,LI JH,JIANG H.Prevention and treatment of relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia［J］.Journal of Clinical Pediatrics,2023,41 (03):167-174.

Memo

Memo:
-
Last Update: 2024-08-30