|Table of Contents|

Expression of disulfidptosis related gene BAK1 in oral squamous cell carcinoma cells and its effect on cell proliferation,migration and invasion

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 19
Page:
3647-3653
Research Field:
Publishing date:

Info

Title:
Expression of disulfidptosis related gene BAK1 in oral squamous cell carcinoma cells and its effect on cell proliferation,migration and invasion
Author(s):
CHEN Yinyu1ZHENG Luxi2ZOU Zichuan2YANG Haonan3MENG Jian14
1.School of Stomatology,Xuzhou Medical University,Jiangsu Xuzhou 221000,China;2.Xuzhou Clinical College of Xuzhou Medical University,Jiangsu Xuzhou 221000,China;3.Shandong Second Medical University,Shandong Weifang 261000,China;4.Department of Stomatology,Xuzhou Central Hospital,Jiangsu Xuzhou 221000,China.
Keywords:
oral squamous cell carcinomadisulfidptosisBAK1cell experimental
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2024.19.004
Abstract:
Objective:To identify novel biomarkers and explore the potential biological value of disulfidptosis in the proliferation,migration,and invasion of oral squamous cell carcinoma.Methods:Retrieve relevant literature and summarize disulfidptosis related genes.Based on the TCGA database,bioinformatics methods were used to identify disulfidptosis related genes with clinical significance,and the biological value of this gene in tumor occurrence and development was explored through cell biology experiments.Results:BAK1 also involves tumor related pathways.Cell biology experiments had shown that BAK1 was highly expressed in oral squamous cell carcinoma.In addition,overexpression or knockdown of BAK1 had a significant impact on cell proliferation,migration,and invasion ability.Conclusion:BAK1 can serve as a new biomarker for oral squamous cell carcinoma and has clinical significance.Meanwhile,disulfidptosis has certain biological value in the proliferation,migration,and invasion of oral squamous cell carcinoma.

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Memo:
国家口腔疾病临床医学研究中心开放课题(编号:NCRCO-202101)
Last Update: 2024-08-30