|Table of Contents|

The research status and development prospects of telomerase inhibitors in the treatment of glioma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3601-3610
Research Field:
Publishing date:

Info

Title:
The research status and development prospects of telomerase inhibitors in the treatment of glioma
Author(s):
CHEN ZhenlinLI JinhuCHEN YiZHANG JiachenLIU Xiaodong
Department of Neurosurgery,the First Hospital of Shanxi Medical University,Shanxi Taiyuan 030000,China.
Keywords:
gliomatelomeretelomerase
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2024.18.032
Abstract:
Telomere is a special structure at the end of a human chromosome that is rich in TTAGGG/AATCCC base pairs and a 3' single strand.Its end is enclosed by the Shelterin protein complex.After each cell division,the telomeres will shorten by a certain amount until reaching a critical value,which will trigger double strand break (DSB) and cause cell death.To achieve long-term survival,cells must have the ability to elongate telomeres.Under normal circumstances,there is mainly an enzyme in human stem cells that has the function of prolonging telomeres,which is called telomerase and mainly composed of catalytic subunits (hTERT) and RNA (hTR).Telomerase expression has been detected in most tumor cells,and even up to 80% of cells in glioblastoma exhibit high telomerase activity.Using telomerase as a target for tumor treatment is highly promising.This article mainly discusses the application of telomerase inhibitors in the treatment of gliomas that have emerged in recent years.

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