［1］ ZHU Y,ZHU X,TANG C,et al.Progress and challenges of immunotherapy in triple-negative breast cancer［J］.Biochimica et Biophysica Acta Reviews on Cancer,2021,1876(2):188593.
［2］ HONG R,XU B.Breast cancer:an up-to-date review and future perspectives［J］.Cancer Communications,2022,42(10):913-936.
［3］ KIM J,BAE JS.Tumor-associated macrophages and neutrophils in tumor microenvironment［J］.Mediators of Inflammation,2016,2016:6058147.
［4］ QIU X,ZHAO T,LUO R,et al.Tumor-associated macrophages:key players in triple-negative breast cancer［J］.Frontiers in Oncology,2022,12:772615.
［5］ VITALE I,MANIC G,COUSSENS LM,et al.Macrophages and metabolism in the tumor microenvironment［J］.Cell Metabolism,2019,30(1):36-50.
［6］ 周舒,蒿艳蓉,吕艳茹,等.三阴性乳腺癌细胞源性外泌体活化的巨噬细胞促进乳腺癌细胞的迁移和侵袭［J］.现代肿瘤医学,2022,30(08):1341-1347.
ZHOU S,HAO YR,LYU YR,et al.Triple-negative breast cancer cell-derived exosome-activated macrophages promote the migration and invasion of breast cancer cells［J］.Modern Oncology,2022,30(08):1341-1347.
［7］ CHEN X,YANG M,YIN J,et al.Tumor-associated macrophages promote epithelial-mesenchymal transition and the cancer stem cell properties in triple-negative breast cancer through CCL2/AKT/β-catenin signaling［J］.Cell Communication and Signaling,2022,20(1):92.
［8］ LU X,YANG R,ZHANG L,et al.Macrophage colony-stimulating factor mediates the recruitment of macrophages in triple negative breast cancer［J］.International Journal of Biological Sciences,2019,15(13):2859-2871.
［9］ ARAUJO JM,GOMEZ AC,AGUILAR A,et al.Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer［J］.Scientific Reports,2018,8(1):4899.
［10］ MICALLEF P,VUJICIC M,WU Y,et al.C1QTNF3 is upregulated during subcutaneous adipose tissue remodeling and stimulates macrophage chemotaxis and M1-like polarization［J］.Frontiers in Immunology,2022,13:914956.
［11］ MOU W,XU Y,YE Y,et al.Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment［J］.Cancer Letters,2015,358(2):115-123.
［12］ DONG F,RUAN S,WANG J,et al.Correction:M2 macrophage-induced lncRNA PCAT6 facilitates tumorigenesis and angiogenesis of triple-negative breast cancer through modulation of VEGFR2［J］.Cell Death & Disease,2022,13(8):752.
［13］ FANTIN A,VIEIRA JM,GESTRI G,et al.Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction［J］.Blood,2010,116(5):829-840.
［14］ CHEN Y,ZHANG S,WANG Q,et al.Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein［J］.Journal of Hematology & Oncology,2017,10(1):36.
［15］ BARBERA-GUILLEM E,NYHUS JK,WOLFORD CC,et al.Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis,and IgG immune complexes potentiate the process［J］.Cancer Research,2002,62(23):7042-7049.
［16］ CH' NG ES,TUAN SHARIF SE,JAAFAR H.In human invasive breast ductal carcinoma,tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis［J］.Virchows Archiv:an International Journal of Pathology,2013,462(3):257-267.
［17］ MAZZIERI R,PUCCI F,MOI D,et al.Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells［J］.Cancer Cell,2011,19(4):512-526.
［18］ GAN L,QIU Z,HUANG J,et al.Cyclooxygenase-2 in tumor-associated macrophages promotes metastatic potential of breast cancer cells through Akt pathway［J］.International Journal of Biological Sciences,2016,12(12):1533-1543.
［19］ HOU Z,FALCONE DJ,SUBBARAMAIAH K,et al.Macrophages induce COX-2 expression in breast cancer cells:role of IL-1β autoamplification［J］.Carcinogenesis,2011,32(5):695-702.
［20］ CHEN J,YAO Y,GONG C,et al.CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3［J］.Cancer Cell,2011,19(4):541-555.
［21］ KITAMURA T,QIAN BZ,SOONG D,et al.CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages［J］.The Journal of Experimental Medicine,2015,212(7):1043-1059.
［22］ FAGET J,BIOTA C,BACHELOT T,et al.Early detection of tumor cells by innate immune cells leads to T(reg) recruitment through CCL22 production by tumor cells［J］.Cancer Research,2011,71(19):6143-6152.
［23］ RUFFELL B,CHANG-STRACHAN D,CHAN V,et al.Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells［J］.Cancer Cell,2014,26(5):623-637.
［24］ FAN Y,HE S.The characteristics of tumor microenvironment in triple negative breast cancer［J］.Cancer Management and Research,2022,14:1-17.
［25］ 张昊,贾永峰,云芬,等.肿瘤相关巨噬细胞在三阴性乳腺癌中的研究进展［J］.中国体视学与图像分析,2021,26(04):382-389.
ZHANG H,JIA YF,YUN F,et al.Progress of tumor-associated macrophages in triple-negative breast cancer［J］.Chinese Journal of Stereology and Image Analysis,2021,26(04):382-389.
［26］ XUAN Q,WANG J,NANDING A,et al.Tumor-associated macrophages are correlated with tamoxifen resistance in the postmenopausal breast cancer patients［J］.Pathology Oncology Research,2014,20(3):619-624.
［27］ CASTELLARO AM,RODRIGUEZ-BAILI MC,DI TADA CE,et al.Tumor-associated macrophages induce endocrine therapy resistance in ER+ breast cancer cells［J］.Cancers,2019,11(2):189.
［28］ PU Y,JI Q.Tumor-associated macrophages regulate PD-1/PD-L1 immunosuppression［J］.Frontiers in Immunology,2022,13:874589.
［29］ LIU Y,TIRUTHANI K,WANG M,et al.Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer［J］.Nanoscale Horizons,2021,6(4):319-329.
［30］ FANG W,YAO M,BRUMMER G,et al.Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment［J］.Oncotarget,2016,7(31):49349-49367.
［31］ SHEN S,ZHANG Y,CHEN K,et al.Cationic polymeric nanoparticle delivering CCR2 siRNA to inflammatory monocytes for tumor microenvironment modification and cancer therapy［J］.Molecular Pharmaceutics,2018,15(9):3642-3653.
［32］ JEDRZEJEWSKI T,PAWLIKOWSKA M,SOBOCINSKA J,et al.Protein-bound polysaccharides from coriolus versicolor fungus disrupt the crosstalk between breast cancer cells and macrophages through inhibition of angiogenic cytokines production and shifting tumour-associated macrophages from the M2 to M1 subtype［J］.Cellular Physiology and Biochemistry,2020,54(4):615-628.
［33］ LI L,YANG L,YANG S,et al.Andrographolide suppresses breast cancer progression by modulating tumor-associated macrophage polarization through the Wnt/β-catenin pathway［J］.Phytotherapy Research,2022,36(12):4587-4603.
［34］ RAMESH A,KUMAR S,NANDI D,et al.CSF1R- and SHP2-inhibitor-loaded nanoparticles enhance cytotoxic activity and phagocytosis in tumor-associated macrophages［J］.Advanced Materials,2019,31(51):e1904364.
［35］ SANCHEZ-GONZALEZ I,BOBIEN A,MOLNAR C,et al.miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages［J］.Cancer Research,2020,80(6):1330-1341.
［36］ DATAR I,QIU X,MA H,et al.RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration［J］.Oncotarget,2015,6(36):39050-39061.
［37］ FENG L,WENG J,YAO C,et al.Extracellular vesicles derived from SIPA1(high) breast cancer cells enhance macrophage infiltration and cancer metastasis through myosin-9［J］.Biology,2022,11(4):543.
［38］ MEHTA AK,CHENEY EM,HARTL CA,et al.Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer［J］.Nature Cancer,2021,2(1):66-82.
［39］ ZHANG Q,LE K,XU M,et al.Combined MEK inhibition and tumor-associated macrophages depletion suppresses tumor growth in a triple-negative breast cancer mouse model［J］.International Immunopharmacology,2019,76:105864.
［40］ LEPLAND A,MALFANTI A,HALJASORG U,et al.Depletion of mannose receptor-positive tumor-associated macrophages via a peptide-targeted star-shaped polyglutamate inhibits breast cancer progression in mice［J］.Cancer Research Communications,2022,2(6):533-551.
［41］ KATARA GK,KULSHRESTHA A,JAISWAL MK,et al.Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment［J］.Oncogene,2016,35(8):1058-1065.
［42］ QIAN H,ZHOU T,FU Y,et al.Self-assembled tetrahedral framework nucleic acid mediates tumor-associated macrophage reprogramming and restores antitumor immunity［J］.Molecular Therapy Nucleic Acids,2022,27:763-773.
［43］ YIN L,FAN Z,LIU P,et al.Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis［J］.Toxicology and Applied Pharmacology,2021,432:115755.
［44］ LI J,CAI H,SUN H,et al.Extracts of cordyceps sinensis inhibit breast cancer growth through promoting M1 macrophage polarization via NF-κB pathway activation［J］.Journal of Ethnopharmacology,2020,260:112969.
［45］ AHN S,SINGH P,JANG M,et al.Gold nanoflowers synthesized using Acanthopanacis cortex extract inhibit inflammatory mediators in LPS-induced RAW264.7 macrophages via NF-κB and AP-1 pathways［J］.Colloids and Surfaces B-Biointerfaces,2018,162:398-404.
［46］ MORADI-CHALESHTORI M,BANDEHPOUR M,HEIDARI N,et al.Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line［J］.International Immunopharmacology,2021,90:107198.
［47］ MA C,HE D,TIAN P,et al.miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression［J］.Proceedings of the National Academy of Sciences of the United States of America,2022,119(6):e2114006119.
［48］ GRIESS B,MIR S,DATTA K,et al.Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part,via Stat3 suppression［J］.Free Radical Biology & Medicine,2020,147:48-60.
［49］ ZHANG X,TIAN W,CAI X,et al.Hydrazinocurcumin encapsuled nanoparticles "re-educate" tumor-associated macrophages and exhibit anti-tumor effects on breast cancer following STAT3 suppression［J］.PLoS One,2013,8(6):e65896.
［50］ JIA X,YU F,WANG J,et al.Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs［J］.Breast Cancer Research and Treatment,2014,148(2):291-302.
［51］ DENG XX,JIAO YN,HAO HF,et al.Taraxacum mongolicum extract inhibited malignant phenotype of triple-negative breast cancer cells in tumor-associated macrophages microenvironment through suppressing IL-10/STAT3/PD-L1 signaling pathways［J］.Journal of Ethnopharmacology,2021,274:113978.
［52］ LIU L,YI H,HE H,et al.Tumor associated macrophage-targeted microRNA delivery with dual-responsive polypeptide nanovectors for anti-cancer therapy［J］.Biomaterials,2017,134:166-179.
［53］ ZHENG Y,WANG N,WANG S,et al.XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling［J］.Cell Communication and Signaling,2020,18(1):48.
［54］ BHATELIA K,SINGH K,SINGH R.TLRs:linking inflammation and breast cancer［J］.Cellular Signaling,2014,26(11):2350-2357.
［55］ CAO X,LI B,CHEN J,et al.Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer［J］.Journal for Immunotherapy of Cancer,2021,9(3):e002022.