［1］HAYKAL MM,RODRIGUES-FERREIRA S,NAHMIAS C.Microtubule-associated protein ATIP3,an emerging target for personalized medicine in breast cancer［J］.Cells,2021,10(5):1080.
［2］ZENG L,LYU X,YUAN J,et al.STMN1 promotes tumor metastasis in non-small cell lung cancer through microtubule-dependent and nonmicrotubule-dependent pathways［J］.International Journal of Biological Sciences,2024,20(4):1509-1527.
［3］VERMA R,AGGARWAL P,BISCHOFF ME,et al.Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells［J］.The Journal of Biological Chemistry,2023,299(5):104663.
［4］XIA X,HE C,WU A,et al.Microtubule-associated protein 4 is a prognostic factor and promotes tumor progression in lung adenocarcinoma［J］.Disease Markers,2018,2018:8956072.
［5］ZHANG J,LI L,ZHANG Q,et al.Phosphorylation of microtubule-associated protein 4 promotes hypoxic endothelial cell migration and proliferation［J］.Front Pharmacol,2019,10:368.
［6］LI L,ZHANG Q,LEI X,et al.MAP4 as a new candidate in cardiovascular disease［J］.Frontiers in Physiology,2020,11:1044.
［7］OLAH J,LEHOTZKY A,SZUNYOGH S,et al.Microtubule-associated proteins with regulatory functions by day and pathological potency at night［J］.Cells,2020,9(2):357.
［8］HONORE S,PASQUIER E,BRAGUER D.Understanding microtubule dynamics for improved cancer therapy［J］.Cell Mol Life Sci,2005,62(24):3039-3056.
［9］STEIN J,KRAPPE E,KREMER A,et al.Expression of the microtubule-associated protein 2 (MAP2) as a potential independent prognostic marker in prostate cancer［J］.Journal of Cancer Research and Clinical Oncology,2024,150(2):76.
［10］SANCHEZ C,DIAZ-NIDO J,AVILA J.Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function［J］.Prog Neurobiol,2000,61(2):133-168.
［11］杨柳松,吕磊,郑佳骏.干扰MAP2基因表达对胶质瘤细胞生物学特性的影响［J］.现代肿瘤医学,2019,27(10):1695-1700.
YANG LS,LYU L,ZHENG JJ.Effect of silencing MAP2 on the biological characteristics of glioma cells［J］.Modern Oncology,2019,27(10):1695-1700.
［12］BHAT KMR,SETALURI V.Microtubule-associated proteins as targets in cancer chemotherapy［J］.Clinical Cancer Research,2007,13(10):2849-2854.
［13］PIRSCOVEANU DFV,PIRICI I,TUDORICA V,et al.Tau protein in neurodegenerative diseases-a review［J］.Rom J Morphol Embryol,2017,58(4):1141-1150.
［14］SU B,WANG X,ZHENG L,et al.Abnormal mitochondrial dynamics and neurodegenerative diseases［J］.Biochim Biophys Acta,2010,1802(1):135-142.
［15］BEHARRY C,COHEN LS,DI J,et al.Tau-induced neurodegeneration:mechanisms and targets［J］.Neuroscience Bulletin,2014,30(2):346-358.
［16］UKMAR-GODEC T,WEGMANN S,ZWECKSTETTER M.Biomolecular condensation of the microtubule-associated protein tau［J］.Semin Cell Dev Biol,2020,99:202-214.
［17］GAO YL,WANG N,SUN FR,et al.Tau in neurodegenerative disease［J］.Ann Transl Med,2018,6(10):175.
［18］HAN X,SEKINO Y,BABASAKI T,et al.Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma［J］.Urologic Oncology,2020,38(6):605.e9-605.e17.
［19］PARYSEK LM,ASNES CF,OLMSTED JB.MAP4:occurrence in mouse tissues［J］.J Cell Biol,1984,99(4 Pt 1):1309-1315.
［20］MANGAN ME,OLMSTED JB.A muscle-specific variant of microtubule-associated protein 4 (MAP4) is required in myogenesis［J］.Development,1996,122(3):771-781.
［21］MATSUSHIMA K,AOSAKI M,TOKURAKU K,et al.Identification of a neural cell specific variant of microtubule-associated protein 4［J］.Cell Struct Funct,2005,29(5-6):111-124.
［22］KREMER BE,HAYSTEAD T,MACARA IG.Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4［J］.Molecular Biology of the Cell,2005,16(10):4648-4659.
［23］PORUCHYNSKY MS,GIANNAKAKOU P,WARD Y,et al.Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism［J］.Biochem Pharmacol,2001,62(11):1469-1480.
［24］HU J,CHU Z,HAN J,et al.Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes［J］.Cell Death & Disease,2014,5:e1424.
［25］OOKATA K,HISANAGA S,SUGITA M,et al.MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells:identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4［J］.Biochemistry,1997,36(50):15873-15883.
［26］DULLOVI A,OZGENCIL M,RAJVEE V,et al.Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase［J］.IScience,2023,26(3):106107.
［27］CHANG W,GRUBER D,CHARI S,et al.Phosphorylation of MAP4 affects microtubule properties and cell cycle progression［J］.J Cell Sci,2001,114(Pt 15):2879-2887.
［28］GOMBOS L,NEUNER A,BERYNSKYY M,et al.GTP regulates the microtubule nucleation activity of gamma-tubulin［J］.Nat Cell Biol,2013,15(11):1317-1327.
［29］OJEDA-LOPEZ MA,NEEDLEMAN DJ,SONG C,et al.Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch［J］.Nature Materials,2014,13(2):195-203.
［30］WATANABE S,GOSHIMA G.Friction on MAP determines its traveling direction on microtubules［J］.Developmental Cell,2014,29(1):5-6.
［31］MATSUSHIMA K,TOKURAKU K,HASAN MR,et al.Microtubule-associated protein 4 binds to actin filaments and modulates their properties［J］.Journal of Biochemistry,2012,151(1):99-108.
［32］SEO M,LEE SO,KIM JH,et al.MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis［J］.Proc Natl Acad Sci U S A,2016,113(50):14390-14395.
［33］OU Y,ZHENG X,GAO Y,et al.Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics［J］.Urol Oncol,2014,32(1):47.
［34］JIANG YY,SHANG L,SHI ZZ,et al.Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma［J］.Oncogene,2016,35(37):4846-4856.
［35］ZHANG S,DEEN S,STORR SJ,et al.Expression of Syk and MAP4 proteins in ovarian cancer［J］.J Cancer Res Clin Oncol,2019,145(4):909-919.
［36］胡萍萍,陈淼,邵睿,等.微管相关蛋白4在胃癌组织中的表达及临床意义［J］.江苏医药,2021,47(10):1001-1004.
HU PP,CHEN M,SHAO R,et al.Expression and significance of microtubule-related protein 4 in gastric cancer［J］.Jiangsu Medical Journal,2021,47(10):1001-1004.
［37］高标,马凡尼,李相磊.微管相关蛋白4对肺腺癌A549细胞迁移、侵袭、增殖和凋亡的影响［J］.癌症进展,2020,18(22):2308-2311+2336.
GAO B,MA FN,LI XL.Effect of microtubule-associated protein 4 on migration,invasion,proliferation and apoptosis of lung adenocarcinoma cell line A549［J］.Oncology Progress,2020,18(22):2308-2311+2336.
［38］XIA X,GE Y,GE F,et al.MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma［J］.Journal of Cancer Research and Clinical Oncology,2024,150(2):88.
［39］李劲松,于建,狄文玉.肺腺癌患者癌组织中MAP4的表达水平及其与病理参数、预后的关系［J］.现代肿瘤医学,2021,29(4):599-603.
LI JS,YU J,DI WY.Expression level of MAP4 in cancer tissues of patients with lung adenocarcinoma and its relationship with pathological parameters and prognosis［J］.Modern Oncology,2021,29(4):599-603.
［40］DMITRIEV AA,ROSENBERG EE,KRASNOV GS,et al.Identification of novel epigenetic markers of prostate cancer by NotI-microarray analysis［J］.Dis Markers,2015,2015:241301.
［41］MURGA PENAS EM,KAWADLER H,SIEBERT R,et al.A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma［J］.Genes Chromosomes Cancer,2006,45(9):863-873.
［42］YEUNG MCF,LAM AYL,SHEK TWH.Novel MAP4:RAF1 fusion in a primary bone sarcoma:Expanding the spectrum of RAF1 fusion sarcoma［J］.Int J Surg Pathol,2022，30（6）:682-688.
［43］BASH-BABULA J,TOPPMEYER D,LABASSI M,et al.A Phase I/pilot study of sequential doxorubicin/vinorelbine:effects on p53 and microtubule-associated protein 4［J］.Clin Cancer Res,2002,8(5):1057-1064.
［44］KAVALLARIS M,TAIT AS,WALSH BJ,et al.Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells［J］.Cancer Res,2001,61(15):5803-5809.
［45］XIAO H,WANG H,ZHANG X,et al.Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4［J］.ACS Chem Biol,2012,7(4):744-752.
［46］陈文杰,李高峰.非小细胞肺癌的分子靶向治疗研究进展［J］.现代肿瘤医学，2017,25(12):1994-1996.
CHEN WJ,LI GF.Research progress on molecular targeted therapy of non-small cell lung cancer［J］.Modern Oncology,2017,25(12):1994-1996.
［47］杨帅,刘相良,李理,等.胃癌分子靶向治疗的研究进展［J］.现代肿瘤医学，2018,26(05):784-789.
YANG S,LIU XL,LI L,et al.Research progress of molecular targeted therapy for gastric carcinoma［J］.Modern Oncology,2018,26(05):784-789.