|Table of Contents|

Therapeutic effect of low-dose azacitidine combined with reduced HAG regimen in the treatment of elderly patients with hypoproliferative acute myeloid leukemia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3532-3536
Research Field:
Publishing date:

Info

Title:
Therapeutic effect of low-dose azacitidine combined with reduced HAG regimen in the treatment of elderly patients with hypoproliferative acute myeloid leukemia
Author(s):
LI JianghuiziWU WenDU MingzhuLI GuangDAI JinqianSONG YanpingLIU Feng
Institute of Hematology of Xi'an,Xi'an Central Hospital,Shaanxi Xi'an 710004,China.
Keywords:
azacitidinehomoharringtoninecytarabineelderly patientshypoproliferative acute myeloid leukemiaefficacy
PACS:
R733.71
DOI:
10.3969/j.issn.1672-4992.2024.18.021
Abstract:
Objective:To evaluate the efficacy and safety of low-dose azacitidine combined with reduced HAG regimen(HHT,Ara-C,G-CSF) in the treatment of newly diagnosed elderly patients with hypoproliferative acute myeloid leukemia.Methods:A retrospective analysis of 56 patients with newly diagnosed hypoproliferative acute myeloid leukemia admitted to our hospital from January 2019 to January 2023 were induced by low-dose azacitidine combined with reduced HAG regimen,to observe the efficacy and evaluate its safety.Results:All 56 patients completed 2 courses of chemotherapy,and their therapeutic effects were evaluated by reexamining bone marrow morphology after peripheral blood count recovery.Among them,25 patients (44.6%) achieved complete remission (CR),11 patients (19.6%) achieved partial remission (PR),and 20 patients (35.7%) achieved no remission (NR),the overall effective rate (ORR) was 64.3% (36/56).56 patients all experienced grade III-IV hematological toxicity,with infection caused by neutropenia and bleeding caused by thrombocytopenia as the main complications.Non hematological toxicity such as nausea,vomiting,decreased appetite,liver and kidney function damage,and cardiac toxicity can be tolerated,and no treatment-related deaths have occurred.Gender,age,and KPS score had no significant impact on the complete response rate (P>0.05).Patients with poor cytogenetics have a lower remission rate than those with normal cytogenetics,with statistical differences (P<0.05).Conclusion:Low-dose azacitidine combined with reduced-dose HAG regimen is effective in the treatment of elderly patients with hypoproliferative acute myeloid leukemia.The remission rate is relatively high and the adverse reactions can be tolerated.

References:

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Last Update: 1900-01-01