|Table of Contents|

The expression and clinical significance of CDC20 in gastric adenocarcinoma tissue

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3502-3506
Research Field:
Publishing date:

Info

Title:
The expression and clinical significance of CDC20 in gastric adenocarcinoma tissue
Author(s):
SUI Wenwen1XIAO Yao2WANG Ruihan2LYU Beibei2
1.Department of Pathology,Dongying District People's Hospital,Shandong Dongying 257000,China;2.Department of Pathology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Shandong Jinan 250021,China.
Keywords:
gastric tumoradenocarcinomaCDC20immunohistochemistryprognosis
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2024.18.016
Abstract:
Objective:To explore the expression and clinical significance of CDC20 in gastric adenocarcinoma tissue.Methods:The mRNA levels of CDC20 in non-neoplastic gastric mucosa and gastric cancer tissues were analyzed using GEPIA database.Immunohistochemistry (SP) was used to detect the expression of CDC20 protein,and its relationship with the clinicopathological features and prognosis of gastric adenocarcinoma was analyzed.Results:GEPIA analysis showed that CDC20 was highly expressed in gastric cancer (P<0.05).Immunohistochemistry results showed that the positive expression rate of CDC20 protein in gastric adenocarcinoma tissue was significantly higher than that of adjacent normal gastric mucosa tissue (P<0.05).And CDC20 expression was significantly associated with lymph node metastasis,TNM stage,and differentiation of gastric adenocarcinoma (P<0.05).Cox proportional hazards regression analysis showed that CDC20 expression was an independent risk factor for the prognosis of gastric adenocarcinoma (P<0.05).Conclusion:CDC20 is highly expressed in gastric adenocarcinoma,which is significantly correlation between tumor staging and lymph node metastasis,and may be a prognostic marker of gastric adenocarcinoma.

References:

[1] ZAVROS Y,MERCHANT JL.The immune microenvironment in gastric adenocarcinoma[J].Nat Rev Gastroenterol Hepatol,2022,19(7):451-467.
[2] 苗智峰,徐忠法,王振宁,等.胃癌早诊早治中国专家共识(2023版)[J].中国消化外科杂志,2024,23(1):23-36. MIAO ZF,XU ZF,WANG ZN,et al.Chinese expert consensus on early diagnosis and treatment of gastric cancer (2023 edition)[J].Chin J Dig Surg,2024,23(1):23-36.
[3] GUAN WL,HE Y,XU RH.Gastric cancer treatment:recent progress and future perspectives[J].J Hematol Oncol,2023,16(1):57.
[4] SUZUKI S,TAKAHASHI A,ISHIKAWA T,et al.Surgically treated gastric cancer in Japan:2011 annual report of the national clinical database gastric cancer registry[J].Gastric Cancer,2021,24(3):545-566.
[5] GREIL C,ENGELHARDT M,WASCH R.The role of the APC/C and its coactivators Cdh1 and Cdc20 in cancer development and therapy[J].Front Genet,2022,13:941565.
[6] PIANO V,ALEX A,STEGE P,et al.CDC20 assists its catalytic incorporation in the mitotic checkpoint complex[J].Science,2021,371(6524):67-71.
[7] DU YG,DENG T,CHENG YH,et al.Enhancing bone regeneration through CDC20-loaded ZIF-8 nanoparticles wrapped in erythrocyte membranes with targeting aptamer[J].Adv Healthc Mater,2024,13(7):e2302725.
[8] HE W,MENG J.CDC20:a novel therapeutic target in cancer[J].Am J Transl Res,2023,15(2):678-693.
[9] CAO Y,LIANG HB,ZHANG F,et al.Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer[J].J Exp Clin Cancer Res,2016,35:68.
[10] OKAMOTO T,SUZUKI H,FUKUDA K.Simultaneous gastric cancer and breast cancer metastases to the stomach with lymph node collision tumor:a case report[J].BMC Gastroenterol,2021,21(1):240.
[11] LE JH,PAN GZ,ZHANG CH,et al.Targeting ferroptosis in gastric cancer:Strategies and opportunities[J].Immunol Rev,2024,321(1):228-245.
[12] TSANG MJ,CHEESEMAN LM.Alternative CDC20 translational isoforms tune mitotic arrest duration[J].Nature,2023,617(7959):154-161.
[13] ZHENG W,ZHAO YB,WANG TS,et al.Identification of hub genes associated with bladder cancer using bioinformatic analyses[J].Transl Cancer Res,2022,11(5):1330-1343.
[14] DAS A,SHARMA HK,LATHER V,et al.Structure-based virtual screening for identification of potential CDC20 inhibitors and their therapeutic evaluation in breast cancer[J].3 Biotech,2023,13(5):141.
[15] JEONG SM,BUI QT,KWAK M,et al.Targeting Cdc20 for cancer therapy[J].Biochim Biophys Acta BBA Rev Cancer,2022,1877(6):188824.
[16] YANG CL,GE YG,ZANG YC,et al.CDC20 promotes radioresistance of prostate cancer by activating Twist1 expression[J].Apoptosis,2023,28(11-12):1584-1595.
[17] BRUNO S,RORA AGL,NAPOLITANO R,et al.CDC20 in and out of mitosis:a prognostic factor and therapeutic target in hematological malignancies[J].J Exp Clin Cancer Res,2022,41(1):159.
[18] ZHANG QL,WANG YM,XUE FX.ASPM,CDC20,DLGAP5,BUB1B,CDCA8,and NCAPG may serve as diagnostic and prognostic biomarkers in endometrial carcinoma[J].Genet Res(Camb),2022,2022:3217248.
[19] DING ZY,WU HR,ZHANG JM,et al.Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis[J].Int J Clin Exp Pathol,2014,7(2):722-727.

Memo

Memo:
National Natural Science Foundation of China(No.82103490);国家自然科学基金青年科学基金项目(编号:82103490);山东省自然科学基金面上项目(编号:ZR2021MH382)
Last Update: 1900-01-01