|Table of Contents|

Research progress of SIRT2 in antitumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3384-3391
Research Field:
Publishing date:

Info

Title:
Research progress of SIRT2 in antitumor
Author(s):
LI Xiaoke1YANG Jingming1YANG Rui2WEI Xiaonan2LI Yanping2
1.School of Stomatology,Jining Medical University,Shandong Jining 272067,China;2.Precision Medicine Laboratory for Chronic Non-communicable Diseases of Shandong Province,Institute of Precision Medicine,Jining Medical University,Shandong Jining 272067,China.
Keywords:
tumorsilent information regulator 2oncogenetumorigenesismolecular mechanism
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2024.17.036
Abstract:
As a member of the sirtuins protein family,silent information regulator 2 (SIRT2) is widely present in eukaryotes.It is a class Ⅲ deacetylase that can regulate biogenesis and metabolism.It is involved in the regulation of cell differentiation,metabolism,aging,repair of DNA damage,maintenance of genome integrity,and tumorigenesis.Abnormal expression of SIRT2 is closely related to the occurrence and development of a variety of tumors.For example,the research progress of SIRT2 in malignant tumors such as breast cancer,cervical cancer,and lung cancer has shown that SIRT2 plays the role of tumor suppressor genes in addition to the role of proto oncogenes.This article mainly reviews the molecular mechanism and research progress of SIRT2 in the development of tumor,in order to provide a new vision for researchers to develop tumor therapeutic drugs.

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Memo

Memo:
National Natural Science Foundation of China(No.82002961);国家自然科学基金青年基金项目(编号:82002961)
Last Update: 2024-07-31