|Table of Contents|

The research progress of the biological function of MEN1 gene in prostate cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3379-3384
Research Field:
Publishing date:

Info

Title:
The research progress of the biological function of MEN1 gene in prostate cancer
Author(s):
SHI Qing1; WANG Ziqi1; LUO Yakun2
1.Department of Urology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China;2.National Health Commission Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy,Harbin Medical University,Heilongjiang Harbin 150001,China.
Keywords:
prostate cancer; MEN1 gene; molecular mechanism; therapeutic strategy
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2024.17.035
Abstract:
During the past two decades,the incidence of prostate cancer has been increasing in China.Specially,prostate cancer has become the three major urological malignancy.Compared with developed countries,the proportion of prostate cancer patients whose first diagnosis is late is still high in our country.Statistics show that more than 70 percent of these patients with advanced prostate cancer have metastases.More importantly,the survival rate will drop to 30%,once these patients develop distant metastases.Thus,investigating for new diagnostic and therapeutic molecular targets has more important practical significance and theoretical value.Accumulating evidence demonstrated the multiple endocrine neoplasia 1(MEN1) gene,encodes menin protein,involved into the occurrence and development of prostate cancer and is a novel potential target for prostate therapy.Herein,we will summarize the structure of MEN1 gene and the biological function of menin in prostate cancer.Meanwhile,we specially focused on the molecular mechanism of menin regulating the proliferation,migration and invasion in prostate cancer cells.The purpose of this review is to provide reference for the further study the function of MEN1 gene or menin protein in prostate cancer.

References:

［1］ BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2024,74(3):229-263.
［2］ ZHENG RS,ZHANG SW,ZENG HM,et al.Cancer incidence and mortality in China,2016［J］.JNCC,2022,2(1):1-9.
［3］ TEO MY,RATHKOPFR DE,KANTOFF P.Treatment of advanced prostate cancer［J］.Annu Rev Med,2019,70:479-499.
［4］ WATSON PA,ARORA VK,SAWYERS CL.Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer［J］.Nat Rev Cancer,2015,15(12):701-711.
［5］ MALIK R,KHAN AP,ASANGANI IA,et al.Targeting the MLL complex in castration-resistant prostate cancer［J］.Nat Med,2015,21(4):344-352.
［6］ TEINTURIER R,LUO Y,DECAUSSIN-PETRUCCI M,et al.Men1 disruption in Nkx3.1-deficient mice results in ARlow/CD44+ microinvasive carcinoma development with the dysregulated AR pathway［J］.Oncogene,2021,40(6):1118-1127.
［7］ FENG Z,MA J,HUA X.Epigenetic regulation by the menin pathway［J］.Endocr Relat Cancer,2017,24(10): T147-T159.
［8］ THAKKER RV,NEWEY PJ,WALLS GV,et al.Clinical practice guidelines for multiple endocrine neoplasia type 1(MEN1) ［J］.J Clin Endocrinol Metab,2012,97(9):2990-3011.
［9］ LEMMENS I,VAN DE VEN WJ,KAS K,et al.Identification of the multiple endocrine neoplasia type 1(MEN1) gene.The European Consortium on MEN1［J］.Hum Mol Genet,1997,6(7):1177-1183.
［10］ HE X,WANG L,YAN J,et al.Menin localization in cell membrane compartment［J］.Cancer Biol Ther,2016,17(1):114-122.
［11］ LA P,DESMOND A,HOU Z,et al.Tumor suppressor menin:the essential role of nuclear localization signal domains in coordinating gene expression［J］.Oncogene,2006,25(25):3537-3546.
［12］ WAUTOT V,KHODAEI S,FRAPPART L,et al.Expression analysis of endogenous menin,the product of the multiple endocrine neoplasia type 1 gene,in cell lines and human tissues［J］.Int J Cancer,2000,85(6):877-81.
［13］ GAO SB,HUA X,JIN GH.Menin regulates endocrine diseases by controlling histone modification and gene transcription［J］.Ann Endocrinol(Paris),2008,69(5):426-432.
［14］ YOKOYAMA A,SOMERVAILLE TC,SMITH KS,et al.The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis［J］.Cell,2005,123(2):207-218.
［15］ GAO SB,FENG ZJ,XU B,et al.Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin［J］.Oncogene,2009,28(46):4095-4104.
［16］ WU G,YUAN M,SHEN S,et al.Menin enhances c-Myc-mediated transcription to promote cancer progression［J］.Nat Commun,2017,8:15278.
［17］ KATONA BW,HOJNACKI T,GLYNN RA,et al.Menin-mediated repression of glycolysis in combination with autophagy protects colon cancer against small-molecule EGFR inhibitors［J］.Mol Cancer Ther,2020,19(11):2319-2329.
［18］ ETELEEB AM,THUNUGUNTLA PK,GELEV KZ,et al.LINC00355 regulates p27KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer［J］.NPJ Breast Cancer,2022,8(1):49.
［19］ TEINTURIER R,ABOU ZIKI R,KASSEM L,et al.Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes［J］.Breast Cancer Res Treat,2021,190(3):389-401.
［20］ AGARWAL SK,GURU SC,HEPPNER C,et al.Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription［J］.Cell,1999,96(1):143-152.
［21］ HENDYG N,KAJI H,SOWA H,et al.Menin and TGF-beta superfamily member signaling via the smad pathway in pituitary,parathyroid and osteoblast［J］.Horm Metab Res,2005,37(6):375-379.
［22］ CAO Y,LIU R,JIANG X,et al.Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of β-catenin［J］.Mol Cell Biol,2009,29(20):5477-5487.
［23］ JIN S,ZHAO H,YI Y,et al.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis［J］.J Clin Invest,2010,120(2):593-606.
［24］ DREIJERINK KMA,GRONER AC,VOS ESM,et al.Enhancer-mediated oncogenic function of the menin tumor suppressor in breast cancer［J］.Cell Rep,2017,18(10):2359-2372.
［25］ HUANG J,GURUNG B,WAN B,et al.The same pocket in menin binds both MLL and JUND but has opposite effects on transcription［J］.Nature,2012,482(7386):542-546.
［26］ BORKIN D,KLOSSOWSKI S,POLLOCK J,et al.Complexity of blocking bivalent protein-protein interactions:Development of a highly potent inhibitor of the menin-mixed-lineage leukemia interaction［J］.J Med Chem,2018,61(11):4832-4850.
［27］ YE J,ZHA J,SHI Y,et al.Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair［J］.Clin Epigenetics,2019,11(1):137.
［28］ GHERARDI S,RIPOCHE D,MIKAELIAN I,et al.Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification［J］.Biochim Biophys Acta Gene Regul Mech,2017,1860(4):427-437.
［29］ ANGEVINE KR,WUESCHER LM,ANDREWS K,et al.Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal duodenum［J］.Nutr Diabetes,2012,2(12):e55.
［30］ KATONA BW,GLYNN RA,PAULOSKY KE,et al.Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription［J］.Cancer Res,2019,79(9):2195-2207.
［31］ HENDY GN,KAJI H,SOWA H,et al.Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary,parathyroid and osteoblast［J］.Horm Metab Res,2005,37(6):375-379.
［32］ IMACHI H,YU X,NISHIUCHI T,et al.Raloxifene inhibits menin-dependent estrogen receptor activation in breast cancer cells［J］.J Endocrinol Invest,2011,34(11):813-815.
［33］ GRASSO CS,WU YM,ROBINSON DR,et al.The mutational landscape of lethal castration-resistant prostate cancer［J］.Nature,2012,487(7406):239-243.
［34］ PERAKAKIS N,FLOHR F,KAYSER G,et al.Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype［J］.Hormones(Athens),2016,15(1):113-117.
［35］ CHEN M,ZHANG J,SAMPIERI K,et al.An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer［J］.Nat Genet,2018,50(2):206-218.
［36］ PARIS PL,ANDAYA A,FRIDLYAND J,et al.Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors［J］.Hum Mol Genet,2004,13(13):1303-1313.
［37］ HESELMEYER-HADDAD KM,BERROA GARCIA LY,BRADLEY A,et al.Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis［J］.Am J Pathol,2014,184(10):2671-2686.
［38］ LUO Y,VLAEMINK-GUILLEM V,TEINTURIER R,et al.The scaffold protein menin is essential for activating the MYC locus and MYC-mediated androgen receptor transcription in androgen receptor-dependent prostate cancer cells［J］.Cancer Commun(Lond),2021,41(12):1427-1430.
［39］ LUO Y,VLAEMINK-GUILLEM V,BARON S,et al.MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin［J］.J Exp Clin Cancer Res,2021,40(1):270.
［40］ CHERIF C,NGUYEN DT,PARIS C,et al.Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity［J］.Oncogene,2022,41(1):125-137.
［41］ SEIGNE C,FONTANIERE S,CARREIRA C,et al.Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice［J］.BMC Cancer,2010,10:395.

Memo

Memo:
黑龙江省属高校基本科研业务经费 （编号：2022KYYWF-0298）;哈尔滨医科大学附属第四医院高层次引进人才基金 （编号：HYDSYRCYJ02） ;黑龙江省留学回国人员择优资助基金 （编号：002277003/2022-21733）
Last Update: 2024-07-31