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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 17

Page:

3367-3372

Research Field:

Publishing date:

Info

Title:

Research progress on the role and mechanism of intestinal flora in the occurrence and development of obesity-related breast cancer

Author(s):

ZHANG Ying¹; WANG Ning²; MA Zhijun³

1.General Surgery Department of Qinghai Provincial People's Hospital,Qinghai Xining 810000,China;2.The Graduate Medical School of Qinghai University,Qinghai Xining 810001,China;3.Department of Tumor Surgery,Affiliated Hospital of Qinghai University,Qinghai Xining 810001,China.

Keywords:

intestinal flora; breast cancer; obesity-related; dietary patterns

PACS:

R737.9

DOI:

10.3969/j.issn.1672-4992.2024.17.033

Abstract:

Intestinal flora plays an important role in the occurrence and development of breast cancer (BC) by affecting hormone levels,participating in immune regulation and regulating metabolites.In recent years,studies have suggested that disordered intestinal flora plays an important role in the progression of obesity-related breast cancer through energy acquisition and lipid metabolism.Therefore,correcting intestinal flora imbalance may be a potential strategy for treatment of breast cancer in the future.This article will review the mechanism and related research of intestinal flora involved in the occurrence and development of obesity-related breast cancer,and provide new ideas for the treatment of obesity-related breast cancer.

References:

£Û1£Ý FUENTES JDB,MORGAN E,DE LUNA AGUILAR A,et al.Global stage distribution of breast cancer at diagnosis:A systematic review and Meta-analysis£ÛJ£Ý.JAMA Oncology,2024,10(1):71-78.
£Û2£Ý FU A,YAO B,DONG T,et al.Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer£ÛJ£Ý.Cell,2022,185(8):1356-1372.e26.
£Û3£Ý HOXHA I,SADIKU F,HOXHA L,et al.Breast cancer and lifestyle factors:Umbrella review£ÛJ£Ý.Hematology/Oncology Clinics,2024,38(1):137-170.
£Û4£Ý PANG Y,WEI Y,KARTSONAKI C.Associations of adiposity and weight change with recurrence and survival in breast cancer patients:a systematic review and meta-analysis£ÛJ£Ý.Breast Cancer,2022,29(4):575-588.
£Û5£Ý SEPICH-POORE GD,ZITVOGEL L,STRAUSSMAN R,et al.The microbiome and human cancer£ÛJ£Ý.Science,2021,371(6536):eabc4552.
£Û6£Ý YANG Q,WANG B,ZHENG Q,et al.A review of gut microbiota-derived metabolites in tumor progression and cancer therapy£ÛJ£Ý.Advanced Science,2023,10(15):2207366.
£Û7£Ý LEVY M,KOLODZIEJCZYK AA,THAISS CA,et al.Dysbiosis and the immune system£ÛJ£Ý.Nature Reviews Immunology,2017,17(4):219-232.
£Û8£Ý TORRES CGP,BARRIOS-RODR¦PGUEZ R,MU£ÎOZ-BRAVO C,et al.Mediterranean diet and risk of breast cancer:An umbrella review£ÛJ£Ý.Clinical Nutrition,2023,42(4):600-608.
£Û9£Ý MOZE¦k ¦k,BUJ¦r¦€KOV¦B D,¦kEF¦gIKOV¦€ Z,et al.Intestinal microflora and obesity in rats£ÛJ£Ý.Folia Microbiologica,2008,53:225-228.
£Û10£Ý TURNBAUGH PJ,B¦FCKHED F,FULTON L,et al.Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome£ÛJ£Ý.Cell Host & Microbe,2008,3(4):213-223.
£Û11£Ý MARTINEZ-GURYN K,HUBERT N,FRAZIER K,et al.Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids£ÛJ£Ý.Cell Host & Microbe,2018,23(4):458-469.e5.
£Û12£Ý OUSSAADA SM,VAN GALEN KA,COOIMAN MI,et al.The pathogenesis of obesity£ÛJ£Ý.Metabolism,2019,92:26-36.
£Û13£Ý ECKER BL,LEE JY,STERNER CJ,et al.Impact of obesity on breast cancer recurrence and minimal residual disease£ÛJ£Ý.Breast Cancer Research,2019,21:1-16.
£Û14£Ý WU KKL, CHEUNG SWM,CHENG KKY.NLRP3 inflammasome activation in adipose tissues and its implications on metabolic diseases£ÛJ£Ý.International Journal of Molecular Sciences,2020,21(11):4184.
£Û15£Ý SCHNEEBERGER M, EVERARD A,G¦VMEZ-VALAD¦IS AG,et al.Akkermansia muciniphila inversely correlates with the onset of inflammation,altered adipose tissue metabolism and metabolic disorders during obesity in mice£ÛJ£Ý.Scientific Reports,2015,5(1):16643.
£Û16£Ý FRUG¦I AD,VANDERPOL W,ROGERS LQ,et al.Fecal akkermansia muciniphila is associated with body composition and microbiota diversity in overweight and obese women with breast cancer participating in a presurgical weight loss trial£ÛJ£Ý.Journal of the Academy of Nutrition and Dietetics,2020,120(4):650-659.
£Û17£Ý ZHANG T,LI Q,CHENG L,et al.Akkermansia muciniphila is a promising probiotic£ÛJ£Ý.Microbial Biotechnology,2019,12(6):1109-1125.
£Û18£Ý HEATH H,MOGOL AN,CASIANO AS,et al.Targeting systemic and gut microbial metabolism in ER+ breast cancer£ÛJ£Ý.Trends in Endocrinology & Metabolism,2024,13:S1043-2760(23)00273-4.
£Û19£Ý PARIDA S,SHARMA D.The microbiome-estrogen connection and breast cancer risk£ÛJ£Ý.Cells,2019,8(12):1642.
£Û20£Ý LIU Y,JIANG X.Research progress on the relationship between sex hormone binding globulin and insulin resistance related diseases£ÛJ£Ý.Shandong Medical Journal,2016,56(46):105-107.
£Û21£Ý SAVVA C,COPSON E,JOHNSON PWM,et al.Obesity is associated with immunometabolic changes in adipose tissue that may drive treatment resistance in breast cancer:immune-metabolic reprogramming and novel therapeutic strategies£ÛJ£Ý.Cancers,2023,15(9):2440.
£Û22£Ý FILIPPONE A,ROSSI C,ROSSI MM,et al.Endocrine disruptors in food,estrobolome and breast cancer£ÛJ£Ý.Journal of Clinical Medicine,2023,12(9):3158.
£Û23£Ý AUNE D,CHAN DSM,GREENWOOD DC,et al.Dietary fiber and breast cancer risk:a systematic review and meta-analysis of prospective studies£ÛJ£Ý.Annals of Oncology,2012,23(6):1394-1402.
£Û24£Ý PACHECO-VE¦BZQUEZL SC,ORTEGA-MEJ¦PAII, VARGAS-NAVARRO JL,et al.17-¦Â Estradiol up-regulates energy metabolic pathways,cellular proliferation and tumor invasiveness in ER+ breast cancer spheroids£ÛJ£Ý.Frontiers in Oncology,2022,12:1018137.
£Û25£Ý MIK¦V E,KOV¦€CS T,SEB¦Z ¦l,et al.Microbiome-microbial metabolome-cancer cell interactions in breast cancer-familiar,but unexplored£ÛJ£Ý.Cells,2019,8(4):293.
£Û26£Ý ALIZADEHMOHAJER N,SHOJAEIFAR S,NEDAEINIA R,et al.Association between the microbiota and women's cancers-cause or consequences£ÛJ£Ý.Biomedicine & Pharmacotherapy,2020,127:110203.
£Û27£Ý SAMPSELL K,HAO D,REIMER RA.The gut microbiota:a potential gateway to improved health outcomes in breast cancer treatment and survivorship£ÛJ£Ý.International Journal of Molecular Sciences,2020,21(23):9239.
£Û28£Ý SUMMER M,SAJJAD A,ALI S,et al.Exploring the underlying correlation between microbiota,immune system,hormones,and inflammation with breast cancer and the role of probiotics,prebiotics and postbiotics£ÛJ£Ý.Archives of Microbiology,2024,206(4):145.
£Û29£Ý CARREGA P,BONACCORSI I,DI CARLO E,et al.CD56 bright perforin low noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph£ÛJ£Ý.The Journal of Immunology,2014,192(8):3805-3815.
£Û30£Ý GILBERT CA,SLINGERLAND JM.Cytokines,obesity,and cancer:new insights on mechanisms linking obesity to cancer risk and progression£ÛJ£Ý.Annual Review of Medicine,2013,64:45-57.
£Û31£Ý MANORE SG,DOHENY DL,WONG GL,et al.IL-6/JAK/STAT3 signaling in breast cancer metastasis:Biology and treatment£ÛJ£Ý.Frontiers in Oncology,2022,12:866014.
£Û32£Ý RATHMELL JC.Obesity,immunity,and cancer£ÛJ£Ý.New England Journal of Medicine,2021,384(12):1160-1162.
£Û33£Ý FESSLER J,MATSON V,GAJEWSKI TF.Exploring the emerging role of the microbiome in cancer immunotherapy£ÛJ£Ý.Journal for Immunotherapy of Cancer,2019,7:1-15.
£Û34£Ý SALIMI V,SHAHSAVARI Z,SAFIZADEH B,et al.Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment£ÛJ£Ý.Lipids in Health and Disease,2017,16(1):1-11.
£Û35£Ý SON MY,CHO HS.Anticancer effects of gut microbiota-derived short-chain fatty acids in cancers£ÛJ£Ý.Journal of Microbiology and Biotechnology,2023,33(7):849.
£Û36£Ý MIRZAEI R,AFAGHI A,BABAKHANI S,et al.Role of microbiota-derived short-chain fatty acids in cancer development and prevention£ÛJ£Ý.Biomedicine & Pharmacotherapy,2021,139:111619.
£Û37£Ý BEAM A,CLINGER E,HAO L.Effect of diet and dietary components on the composition of the gut microbiota£ÛJ£Ý.Nutrients,2021,13(8):2795.
£Û38£Ý KOV¦BCS T,MIK¦„ E,VIDA A,et al.Cadaverine,a metabolite of the microbiome,reduces breast cancer aggressiveness through trace amino acid receptors£ÛJ£Ý.Scientific Reports,2019,9(1):1300.
£Û39£Ý MIK¦„ E,VIDA A,KOV¦BCS T,et al.Lithocholic acid,a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness£ÛJ£Ý.Biochimica at Biophysica Acta(BBA)-Bioenergetics,2018,1859(9):958-974.
£Û40£Ý SHIVELYCA,REGISTER TC,APPT SE,et al.Consumption of mediterranean versus Western diet leads to distinct mammary gland microbiome populations£ÛJ£Ý.Cell Reports,2018,25(1):47-56.e3.
£Û41£Ý LAZAR V,DITU LM,PIRCALABIORU GG,et al.Gut microbiota,host organism,and diet trialogue in diabetes and obesity£ÛJ£Ý.Frontiers in Nutrition,2019,6:21.
£Û42£Ý ZMORA N,SUEZ J,ELINAVL E.You are what you eat:diet,health and the gut microbiota£ÛJ£Ý.Nature Reviews Gastroenterology & Hepatology,2019,16(1):35-56.
£Û43£Ý MANSOUR S,ALKHAALDI SMI,SAMMANASUNATHAN AF,et al.Precision nutrition unveiled:Gene-nutrient interactions,microbiota dynamics,and lifestyle factors in obesity management£ÛJ£Ý. Nutrients,2024,16(5):581.
£Û44£Ý LAKRITZ JR,POUTAHIDIS T,MIRABAL S,et al.Gut bacteria require neutrophils to promote mammary tumorigenesis£ÛJ£Ý.Oncotarget,2015,6(11):9387.
£Û45£Ý SALMINEN S,COLLADO MC,ENDO A,et al.The international scientific association of probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics£ÛJ£Ý.Nature Reviews Gastroenterology & Hepatology,2021,18(9):649-667.
£Û46£Ý ZHOU P,CHEN C,PATIL S,et al.Unveiling the therapeutic symphony of probiotics,prebiotics,and postbiotics in gut-immune harmony£ÛJ£Ý.Frontiers in Nutrition,2024,11:1355542.

Memo

Memo:

National Natural Science Foundation of China£¨No.82060485£©;¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÏîÄ¿£¨±àºÅ£º82060485£©

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Last Update: 2024-07-31