|Table of Contents|

Progress in the clinical application of miR-142 in malignant solid tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3360-3366
Research Field:
Publishing date:

Info

Title:
Progress in the clinical application of miR-142 in malignant solid tumors
Author(s):
WU Ting1; MO Liang2; YANG Xinzhi1; YOU Yong1
1.Research Laboratory of Translational Medicine,Hengyang Medical School,University of South China,Hunan Hengyang 421001,China;2.Department of Thoracic Surgery，the First Affiliated Hospital,Hengyang Medical School,University of South China,Hunan Hengyang 421001,China.
Keywords:
malignant solid tumors; miR-142; chemotherapy resistance; autophagy; therapeutic targets
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2024.17.032
Abstract:
miR-142 is an evolutionarily conserved non-coding RNA localized at 17q22 and is closely associated with the development of many malignant solid tumors.miR-142 is aberrantly expressed in many malignant solid tumors,including breast,lung,liver,colorectal,gastric and cervical cancers,and is involved in a series of biological processes such as malignant cell proliferation and metastasis,cell cycle,autophagy and chemotherapy resistance.In this paper,based on the existing literature,we systematically review the expression of these tumors.Based on the existing literature,this paper systematically reviews the molecular mechanisms of miR-142 in the progression of different malignant solid tumors and provides new ideas for subsequent clinical application studies in malignant solid tumors.

References:

［1］ CHEN CZ,LI L,LODISH HF,et al.MicroRNAs modulate hematopoietic lineage differentiation［J］.Science,2004,303(5654):83-86.
［2］ PAHLAVAN Y,MOHAMMADI NASR M,DALIR ABDOLAHINIA E,et al.Prominent roles of microRNA-142 in cancer［J］.Pathol Res Pract,2020,216(11):153220.
［3］ LIU R,ZHENG S,YU K,et al.Prognostic value of miR-142 in solid tumors:a meta-analysis［J］.Biosci Rep,2021,41(2):BSR20204043.
［4］ LIU J,TIAN W,ZHANG W,et al.MicroRNA-142-3p/MALAT1 inhibits lung cancer progression through repressing β-catenin expression［J］.Biomed Pharmacother,2019,114:108847.
［5］ ZENG C,YUAN G,HU Y,et al.Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma［J］.Bioengineered,2022,13(1):1491-1506.
［6］ WANG H,SUN G,XU P,et al.Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p［J］.J Gastroenterol,2021,56(2):125-138.
［7］ HUANG B,CUI DJ,YAN F,et al.Circ_0087862 promotes the progression of colorectal cancer by sponging miR-142-3p and up-regulating BACH1 expression［J］.Kaohsiung J Med Sci,2021,37(12):1048-1057.
［8］ SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2021,71(3):209-249.
［9］ XU T,HE BS,PAN B,et al.MiR-142-3p functions as a tumor suppressor by targeting RAC1/PAK1 pathway in breast cancer［J］.Journal of Cellular Physiology,2020,235(5):4928-4940.
［10］ MANSOORI B,DUIJF PHG,MOHAMMADI A,et al. MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy［J］.Life Sci,2021,276:119431.
［11］ YU W,LI D,ZHANG Y,et al.MiR-142-5p acts as a significant regulator through promoting proliferation,invasion,and migration in breast cancer modulated by targeting SORBS1［J］.Technol Cancer Res Treat,2019,18:1533033819892264.
［12］ JIN CE,XIAO L,ZHOU Z,et al.MiR-142-3p suppresses the proliferation,migration and invasion through inhibition of NR2F6 in lung adenocarcinoma［J］.Hum Cell,2019,32(4):437-446.
［13］ ZHANG Q,LIU H,ZHANG J,et al.MiR-142-5p suppresses lung cancer cell metastasis by targeting yin yang 1 to regulate epithelial-mesenchymal transition［J］.Cell Reprogram,2020,22(6):328-336.
［14］ JIA Y,DUAN Y,LIU T,et al.LncRNA TTN-AS1 promotes migration,invasion,and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5［J］.Cell Death Dis,2019,10(8):573.
［15］ LIU Q,YU X,YANG M,et al.A study of the mechanism of lncRNA-CR594175 in regulating proliferation and invasion of hepatocellular carcinoma cells in vivo and in vitro［J］.Infect Agent Cancer,2020,15:55.
［16］ ZHANG J,SHAN WF,JIN TT,et al.Propofol exerts anti-hepatocellular carcinoma by microvesicle-mediated transfer of miR-142-3p from macrophage to cancer cells［J］.J Transl Med,2014,12:279.
［17］ HU Z,YIN Y,JIANG J,et al.Exosomal miR-142-3p secreted by hepatitis B virus(HBV)-hepatocellular carcinoma(HCC) cells promotes ferroptosis of M1-type macrophages through SLC3A2 and the mechanism of HCC progression［J］.J Gastrointest Oncol,2022,13(2):754-767.
［18］ LIU P,CAO F,SUI J,et al.MicroRNA-142-3p inhibits tumorigenesis of colorectal cancer via suppressing the activation of wnt signaling by directly targeting to β-Catenin［J］.Front Oncol,2020,10:552944.
［19］ REN J,LI W,PAN G,et al.miR-142-3p modulates cell invasion and migration via PKM2-mediated aerobic glycolysis in colorectal cancer［J］.Anal Cell Pathol (Amst),2021,2021:9927720.
［20］ LIU S,XIAO Z,AI F,et al.miR-142-5p promotes development of colorectal cancer through targeting SDHB and facilitating generation of aerobic glycolysis［J］.Biomed Pharmacother,2017,92:1119-1127.
［21］ YAN J,YANG B,LIN S,et al.Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer［J］.Gastric Cancer,2019,22(2):302-313.
［22］ LING J,SUN Q,TIAN Q,et al.Human papillomavirus 16 E6/E7 contributes to immune escape and progression of cervical cancer by regulating miR-142-5p/PD-L1 axis ［J］.Arch Biochem Biophys,2022,731:109449.
［23］ SHARMA P,YADAV P,JAIN RP,et al.miR-142-3p simultaneously targets HMGA1,HMGA2,HMGB1,and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells［J］.Life Sci,2022,291:120268.
［24］ GUO J,TANG T,LI J,et al.Overexpression of MicroRNA 142-5p suppresses the progression of cervical cancer through targeting phosphoinositol-3-Kinase adaptor protein 1 expression［J］.Mol Cell Biol,2021,41(6):e0036320.
［25］ KE L,CHEN Y,LI Y,et al.miR-142-5p promotes cervical cancer progression by targeting LMX1A through Wnt/β-catenin pathway［J］.Open Med(Wars),2021,16(1):224-236.
［26］ PENG X,PAN X,LIU K,et al.miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery［J］.Int J Biol Markers,2019,34(3):302-308.
［27］ ZHU M,ZOU L,LU F,et al.miR-142-5p promotes renal cell tumorigenesis by targeting TFAP2B［J］.Oncol Lett,2020,20(6):324.
［28］ ZHANG S,WANG Q,LI W,et al.MIR100HG regulates CALD1 gene expression by targeting miR-142-5p to affect the progression of bladder cancer cells in vitro,as revealed by transcriptome sequencing［J］.Front Mol Biosci,2021,8:793493.
［29］ LI W Q,ZHAO WC,XIN J,et al.MicroRNA-142-3p suppresses cell proliferation and migration in bladder cancer via Rac1［J］.J Biol Regul Homeost Agents,2020,34(1):83-92.
［30］ LU Y,JI N,WEI W,et al.MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments［J］.Biol Open,2017,6(2):252-259.
［31］ LENCE T,PAOLANTONI C,WORPENBERG L,et al.Mechanistic insights into m6A RNA enzymes［J］.Biochim Biophys Acta Gene Regul Mech,2019,1862(3):222-229.
［32］ JIANG R,DAI Z,WU J,et al.METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells［J］.Cell Death Discov,2022,8(1):179.
［33］ CHEN Y,ZHOU X,QIAO J,et al.MiR-142-3p overexpression increases chemo-sensitivity of NSCLC by inhibiting HMGB1-mediated autophagy［J］.Cell Physiol Biochem,2017,41(4):1370-1382.
［34］ PENG L,SANG H,WEI S,et al.circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2［J］.Mol Cancer,2020,19(1):156.
［35］ SHI Y,WANG J,TAO S,et al.miR-142-3p improves paclitaxel sensitivity in resistant breast cancer by inhibiting autophagy through the GNB2-AKT-mTOR pathway［J］.Cell Signal,2023,103:110566.
［36］ WANG L,ZHOU Y,JIANG L,et al.CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142,upregulating WWP1 and activating the PI3K/AKT pathway［J］.Mol Cancer,2021,20(1):43.
［37］ LIANG L,FU J,WANG S,et al.MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1［J］.Acta Pharm Sin B,2020,10(6):1036-1046.
［38］ ZHANG K,CHEN J,ZHOU H,et al.PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib ［J］.Cell Death Dis,2018,9(3):312.
［39］ HE YZ,YU SL,LI XN,et al.Curcumin increases crizotinib sensitivity through the inactivation of autophagy via epigenetic modulation of the miR-142-5p/Ulk1 axis in non-small cell lung cancer［J］.Cancer Biomark,2022,34(2):297-307.
［40］ LI X,CHEN W,JIN Y,et al.miR-142-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes［J］.Biochem Pharmacol,2019,161:98-112.
［41］ ZHU K,YUAN Y,WEN J,et al.LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22［J］.Aging(Albany NY),2020,12(8):6644-6666.

Memo

Memo:
湖南省自然科学基金（编号：2021JJ30618,2022JJ50158）；湖南省临床医疗技术创新引导项目（编号：2020SK51825）
Last Update: 2024-07-31