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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 17

Page:

3335-3341

Research Field:

Publishing date:

Info

Title:

Ferroptisis and its mechanism and research progress in radiotherapy and chemotherapy of glioblastoma

Author(s):

JIN Shaohua¹; ZHANG Xiaoqing²; MA Chunzheng³; LI Dongdong³; ZHANG Juan¹; 3

1.The Second Clinical Medical College of Henan University of Traditional Chinese Medicine,Henan Zhengzhou 450046,China;2.The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China;3.The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450053,China.

Keywords:

ferroptosis; glioblastoma; radiotherapy; chemotherapy; research progress

PACS:

R739.41

DOI:

10.3969/j.issn.1672-4992.2024.17.028

Abstract:

Glioblastoma (GBM) is one of the most common primary malignant brain tumors in the adult central nervous system.Even after active treatment such as surgical resection,radiotherapy,and chemotherapy,the survival period is still very short,and GBM cells' resistance to radiotherapy and chemotherapy is the main reason for their treatment failure.In recent years,numerous studies have found that iron death related processes can mediate the efficacy of GBM treatment.This article provides an overview of ferroptosis and its regulatory mechanisms in GBM,and explores the feasibility of inducing ferroptosis in the sensitization of glioblastoma to radiotherapy and chemotherapy.The aim is to provide reference for reversing the resistance of GBM cells to radiotherapy and chemotherapy,and to provide a new direction for targeted ferroptosis to improve the therapeutic efficacy of GBM.

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Memo

Memo:

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