|Table of Contents|

Prediction of histopathological grade and proliferative activity of glioma by FSE/MDME sequence combined with DWI

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3314-3319
Research Field:
Publishing date:

Info

Title:
Prediction of histopathological grade and proliferative activity of glioma by FSE/MDME sequence combined with DWI
Author(s):
ZHANG Lihong; WAN Zhengguo; TIAN Zhiyong; LI Jing
CT Room of Handan First Hospital,Hebei Handan 056004,China.
Keywords:
magnetic resonance; diffusion-weighted imaging; glioma; histopathology; proliferation
PACS:
R739.41
DOI:
10.3969/j.issn.1672-4992.2024.17.024
Abstract:
Objective:To construct the clinical efficacy of FSE/MDME combined with DWI magnetic resonance in predicting of histopathological grade and relationship with proliferative activity of glioma to provides more reference for early identification of high grade and high proliferative population.Methods:137 patients with glioma confirmed by histopathological examination after surgery were retrospectively chosen in the period from January 2018 to January 2023 in our hospital and grouped into high grade group (82 cases) and low grade group (55 cases) according to histopathological grade.The baseline clinical data and quantitative analysis of magnetic resonance imaging of 2 groups were compared.FSE/MDME combined with DWI magnetic resonance was used to predict the clinical efficacy of glioma histopathological grade.Results:There was no significant difference in baseline clinical data between 2 groups（P＞0.05）.The T1 value and proton density of low grade group were significantly lower than high grade group（P＜0.05）.The apparent dispersion coefficient of low grade group was significantly higher than high grade group（P＜0.05）.There was no significant difference in T2 values between 2 groups（P＞0.05）.T1 value,proton density and apparent dispersion coefficient can be used to predict the grade of glioma histology.The apparent dispersion coefficient of single index is significantly higher than T1 value and proton density in of single index is significantly higher than T1 value and proton density in predicting AUC,and the combined prediction efficiency of the three indexes is better than that of the three indexes alone (P＜0.05).The apparent diffusion coefficient of glioma patients was negatively correlated with the proportion of Ki-67 positive cells,while T1 and proton density were positively correlated with the proportion of Ki-67 positive cells (P＜0.05).However,there was no correlation between T2 and Ki-67 positive cells (P＞0.05).Conclusion:FSE/MDME combined with DWI magnetic resonance can be used to predict the pathological grade of glioma,and the combination of T1 value,proton density and apparent dispersion coefficient is the best predictor.At the same time,the above quantitative magnetic resonance analysis indexes were related to the proliferation activity of glioma histocyte.

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河北省邯郸市科学技术研究与发展计划项目（编号：19422083010-9）
Last Update: 2024-07-31