|Table of Contents|

Correlation analysis between background parenchymal enhancement level in mammography and different molecular types and clinical factors of breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3305-3313
Research Field:
Publishing date:

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Title:
Correlation analysis between background parenchymal enhancement level in mammography and different molecular types and clinical factors of breast cancer
Author(s):
LI Hongen; ZENG Yihui; LI Yuelong; HUANG Yubin; LI Chengwei; ZHANG Li
Department of Radiology,Guangdong Province Hospital for Women and Children Healthcare，Guangdong Guangzhou 511400,China.
Keywords:
contrast-enhanced spectral mammography; breast cancer; breast background parenchymal enhancement; molecular typing
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.17.023
Abstract:
Objective:To explore the correlation between background parenchymal enhancement(BPE) level in contrast-enhanced energy spectrum mammography(CESM) examination and different molecular types of breast cancer and common prognostic markers.Methods:A retrospective analysis was performed on 61 cases of breast cancer diagnosed by postoperative pathology and immunohistochemistry in our hospital from June 2019 to October 2022.CESM examination was performed before surgery.The scope of BPE enhancement on CESM low-energy map of healthy breast was divided into four categories:minimal,mild,moderate,and severe.Statistical analysis was divided into two groups:low BPE group with minimal and mild BPE,and high BPE group with moderate and severe BPE.The strength of BPE strengthening can be divided into symmetric and asymmetric.Spearman correlation test was used to analyze the correlation between the scope and intensity of BPE enhancement and clinical characteristics(age,age of menarche,menopausal status).Univariate ANOVA was used to compare the extent and intensity of BPE enhancement with lymph node metastasis,family history of breast cancer,fibroglandular content,TNM stage,immunohistochemical markers,and molecular typing.Results:Among the 61 patients with breast cancer,the pathological types were as follows:invasive breast cancer in 47 cases(77.05%),ductal carcinoma in situ in 10 cases(16.39%),papillary malignant tumor in 2 cases(3.28%),lobular carcinoma in situ in 2 cases(3.28%).Molecular types:Luminal A type 15 cases(24.59%),Luminal B type 27 cases(44.26%),Her-2 overexpression type 12 cases(19.67%),TNBC type 7 cases(11.48%).The range of BPE intensity was 34 cases(55.74%) in low BPE group and 27 cases(44.26%) in high BPE group.Analysis of clinical characteristics:The range of BPE intensity was negatively correlated with the age and menopausal status of the patients(r=-0.378,-0.353,P=0.003,0.005).Chi-square test showed that the range of BPE intensity was significantly different from the age and menopausal status of the patients(χ2=9.669,7.592,P=0.008,0.006).There was no correlation between the extent and intensity of BPE enhancement and the age of menarche(P＞0.05).There was no significant difference between the extent and intensity of BPE enhancement and lymph node metastasis,family history of breast cancer,histological classification,TNM stage,immunohistochemical markers and molecular typing(all P＞0.05).Conclusion:In CESM examination,the extent of BPE enhancement was correlated with patient age and menopause,and there was no statistically significant difference between BPE level and molecular classification of breast cancer.

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Last Update: 2024-07-31