|Table of Contents|

Acupuncture and moxibustion(Qihai CV6,Guanyuan CV4 and Zusanli ST36) for chemotherapy-induced cancer-related fatigue in patients with colorectal cancer：A randomized controlled trial

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3296-3305
Research Field:
Publishing date:

Info

Title:
Acupuncture and moxibustion(Qihai CV6,Guanyuan CV4 and Zusanli ST36) for chemotherapy-induced cancer-related fatigue in patients with colorectal cancer：A randomized controlled trial
Author(s):
DU Xiuting1; LIU Peng2; HUANG Yujun1; HUANG Qiuhua1; CHEN Nan1; CHEN Yanqiu1; PAN Shaona1; LUO Yuejia1; QIAO Guanying1
1.Department of Medical Oncology,Shunde Hospital Guangzhou University of Chinese Medicine,Guangdong Foshan 528000,China;2.Department of Medical Oncology,Shenzhen Hospital(Longgang),Beijing University of Chinese Medicine,Guangdong Shenzhen 518172,China.
Keywords:
Qihai(CV6); Guanyuan(CV4); Zusanli(ST36); acupuncture-moxibustion; cancer-related fatigue(CRF); control study
PACS:
R735.3+5
DOI:
10.3969/j.issn.1672-4992.2024.17.022
Abstract:
Objective:To observe the clinical therapeutic effect on cancer-related fatigue(CRF) after chemotherapy treatment with the reinforcing technique of acupuncture at Qihai(CV6)，Guanyuan(CV4） and warm needling on bilateral Zusanli(ST36) in the patients with colorectal cancer as well as its effect on TNF-α.Methods:A total of 51 cases of CRF after chemotherapy for colorectal cancer were included in the final analysis which randomized into an acupuncture group(25 cases) and a control group(26 cases).The patients of the two groups took regular chemotherapy.In the acupuncture group patients were treated with and chemotherapy.The acupuncture treatment was performed at day 1 before chemotherapy and from day 1 to day 3 of chemotherapy separately,once daily,30 min each time,for two courses(eight treatments) in total.The primary outcome was Piper fatigue scale(PFS),and the secondary efficacy index was TCM syndrome score and TNF-α content.Assessments were performed before the first course of chemotherapy after randomization,after the end of the second course of chemotherapy,and 2 weeks after the second course of chemotherapy.Results:Regarding the Piper fatigue score,as the number of acupuncture and moxibustion interventions increased,the Piper fatigue scores of the patients in the acupuncture group gradually decreased（F=67.425,P<0.001）,suggesting that the degree of cancer-related fatigue in the acupuncture group improved over time.Compared with the control group,the Piper fatigue score in the acupuncture group decreased significantly（F=6.706,P=0.013）,indicating that the fatigue level of patients in the acupuncture group had significantly improved better than patients in the control group.Regarding the TCM syndrome score,the effective rates of the acupuncture group and the control group were 68% and 34.6%,respectively,and the effective rates of the acupuncture group were significantly increased(χ2=5.68,P=0.017).Among them,the single symptoms of "fatigue"(χ2=14.41,P<0.001),"mental fatigue"(χ2=7.06,P<0.008) in the acupuncture group were also significantly improved compared with the control group.After treatment,the content of TNF-α in the acupuncture group decreased compared with that before treatment(t=1.14,P=0.26),while the content of TNF-α in the control group increased compared with that before treatment(t=-1.02,P=0.31).Therefore,acupuncture had a tendency to inhibit TNF-α content in patients with cancer-related fatigue.Conclusion:The acupuncture treatment of Qihai,Guanyuan and bilateral Zusanli can reduce fatigue among cancer patients with cancer-related fatigue caused by chemotherapy.It can improve the symptoms of "fatigue","mental fatigue",and has a tendency to downregulate the level of TNF-α.It is preliminarily suggested that the downregulation of TNF-α proinflammatory cytokines may be one of the mechanisms of acupuncture in the treatment of cancer-related fatigue.

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Memo:
广东省中医药局中医药科研项目（编号：20212226）；北京中医药大学深圳医院育龙计划专项科研项目（编号：2022-BUCMSZYLRC21）
Last Update: 2024-07-31