|Table of Contents|

Research progress on roles of follicular helper T cells in malignant hematological diseases

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3125-3130
Research Field:
Publishing date:

Info

Title:
Research progress on roles of follicular helper T cells in malignant hematological diseases
Author(s):
GONG Shan1; ZHANG Ranran1; QU Jianhua2
1.The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011，China；2.Department of Hematology,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011，China.
Keywords:
follicular helper T cells; lymphoma; myelodysplastic syndrome; multiple myeloma; leukemia
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2024.16.029
Abstract:
Follicular helper T cells (Tfh) belong to the CD4+T cell subgroup and have unique phenotypic and functional characteristics.Tfh cells exist in the germinal center of lymphoid tissue and peripheral blood,and have the functions of supporting the formation of the germinal center (GC) of lymphoid follicles,promoting the maturation of B cells,and determining the differentiation of B cells,as well as the production and class switch of antibodies.The abnormality of its populations,functions and subtypes is related to the occurrence,progression and prognosis of malignant hematological diseases.This article reviews the differentiation and classification of Tfh cells,as well as their expression and role in different types of malignant hematological diseases,in order to provide a new insight into revealing the pathogenesis of lymphoma,myelodysplastic syndrome,leukemia and other diseases,and treating those diseases by targeting Tfh cells.

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