［1］ CHEUNG EC,VOUSDEN KH.The role of ROS in tumour development and progression［J］.Nat Rev Cancer,2022,22(5):280-297.
［2］ HORNING KJ,CAITO SW,TIPPS KG,et al.Manganese is essential for neuronal health［J］.Annu Rev Nutr,2015,35:71-108.
［3］ MENGFAN L,XUEYANG S,BOYA C,et al.Insights into manganese superoxide dismutase and human diseases［J］.International Journal of Molecular Sciences,2022,23(24):15893.
［4］ SONG M,LIU T,SHI C,et al.Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia［J］.ACS Nano,2016,10(1):633-647.
［5］ ZHOU L,YANG Z,GUO L,et al.Noninvasive assessment of kidney injury by combining structure and function using artificial intelligence-based manganese-enhanced magnetic resonance imaging［J］.ACS Applied Materials & Interfaces,2024,16(5):5474-5485.
［6］ QINGBIN H,RUNXIAO Z,JUNCHI M,et al.Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy［J］.Biomaterials Research,2023,27(1):29.
［7］ SUN X,ZHANG Y,LI J,et al.Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy［J］.Nature Nanotechnology,2021,16(11):1260-1270.
［8］ HUANG S,GAO Y,LI H,et al.Manganese@albumin nanocomplex and its assembled nanowire activate TLR4-dependent signaling cascades of macrophages［J］.Advanced Materials (Deerfield Beach,Fla),2024,36(5):e2310979.
［9］ ZHANG S,KANG L,DAI X,et al.Manganese induces tumor cell ferroptosis through type-Ⅰ IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase［J］.Free Radic Biol Med,2022,193(Pt 1):202-212.
［10］ RAO L,ZHAO SK,WEN C,et al.Activating macrophage-mediated cancer immunotherapy by genetically edited nanoparticles［J］.Adv Mater,2020,32(47):e2004853.
［11］ GUNASSEKARAN GR,POONGKAVITHAI VADEVOO SM,BAEK MC,et al.M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages［J］.Biomaterials,2021,278:121137.
［12］ HOU L,TIAN C,YAN Y,et al.Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity［J］.ACS Nano,2020,14(4):3927-3940.
［13］ ZHAO Y,PAN Y,ZOU K,et al.Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy［J］.Bioact Mater,2023,19:237-250.
［14］ LIU XZ,WEN ZJ,LI YM,et al.Bioengineered bacterial membrane vesicles with multifunctional nanoparticles as a versatile platform for cancer immunotherapy［J］.ACS Appl Mater Interfaces,2023,15(3):3744-3759.
［15］ BHANDARI V,HOEY C,LIU LY,et al.Molecular landmarks of tumor hypoxia across cancer types［J］.Nat Genet,2019,51(2):308-318.
［16］ CHEN Q,CHEN J,YANG Z,et al.Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy［J］.Adv Mater,2019,31(10):e1802228.
［17］ LU WL,LAN YQ,XIAO KJ,et al.BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer［J］.J Mater Chem B,2017,5(6):1275-1283.
［18］ LI W,LI R,YE Q,et al.Mn(3) O(4) nanoshell coated metal-organic frameworks with microenvironment-driven O(2) production and GSH exhaustion ability for enhanced chemodynamic and photodynamic cancer therapies［J］.Adv Healthc Mater,2023,12(15):e2202280.
［19］ ZHU DM,WU L,SUO M,et al.Engineered red blood cells for capturing circulating tumor cells with high performance［J］.Nanoscale,2018,10(13):6014-6023.
［20］ LI N,YU L,WANG J,et al.A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy［J］.Chem Sci,2018,9(12):3159-3164.
［21］ WANG Y,LIU Z,WANG H,et al.Starvation-amplified CO generation for enhanced cancer therapy via an erythrocyte membrane-biomimetic gas nanofactory［J］.Acta Biomater,2019,92:241-253.
［22］ CIOCCI M,IORIO E,CAROTENUTO F,et al.H2S-releasing nanoemulsions:a new formulation to inhibit tumor cells proliferation and improve tissue repair［J］.Oncotarget,2016,7(51):84338-84358.
［23］ LI L,WHITEMAN M,GUAN YY,et al.Characterization of a novel,water-soluble hydrogen sulfide-releasing molecule (GYY4137):new insights into the biology of hydrogen sulfide［J］.Circulation,2008,117(18):2351-2360.
［24］ HE T,QIN X,JIANG C,et al.Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy［J］.Theranostics,2020,10(6):2453-2462.
［25］ CAI X,ZHU Q,ZENG Y,et al.Manganese oxide nanoparticles as MRI contrast agents in tumor multimodal imaging and therapy［J］.Int J Nanomedicine,2019,14:8321-8344.
［26］ YANG G,XIA J,DAI X,et al.A targeted multi-crystalline manganese oxide as a tumor-selective nano-sized MRI contrast agent for early and accurate diagnosis of tumors［J］.International Journal of Nanomedicine,2024,19:527-540.
［27］ LI X,ZHAO W,LIU X,et al.Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T1-MRI contrast agents and drug delivery carriers［J］.Acta Biomater,2016,30:378-387.
［28］ ZHU H,ZHANG L,LIU Y,et al.Aptamer-PEG-modified Fe(3)O(4)@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells［J］.Sci Rep,2016,6:39245.
［29］ FU L,ZHANG W,ZHOU X,et al.Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma［J］.Bioact Mater,2022,17:221-233.
［30］ CHUNXING L,YUN W,HUAYAN N,et al.Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe［J］.Nanotechnology,2021,33(2):5101.
［31］ BRANDT M,CARDINALE J,RAUSCH I,et al.Manganese in PET imaging:Opportunities and challenges［J］.J Labelled Comp Radiopharm,2019,62(8):541-551.
［32］ BANERJEE A,BERTOLESI GE,LING CC,et al.Bifunctional pyrrolidin-2-one terminated manganese oxide nanoparticles for combined magnetic resonance and fluorescence imaging［J］.ACS Appl Mater Interfaces,2019,11(14):13069-13078.
［33］ LI H,KIM Y,JUNG H,et al.Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy［J］.Chem Soc Rev,2022,51(21):8957-9008.
［34］ FAROKHI M,MOTTAGHITALAB F,SAEB MR,et al.Functionalized theranostic nanocarriers with bio-inspired polydopamine for tumor imaging and chemo-photothermal therapy［J］.J Control Release,2019,309:203-219.
［35］ SONG ZL,DAI X,LI M,et al.Biodegradable nanoprobe based on MnO(2) nanoflowers and graphene quantum dots for near infrared fluorescence imaging of glutathione in living cells［J］.Mikrochim Acta,2018,185(10):485.
［36］ WANG Y,ZOU L,QIANG Z,et al.Enhancing targeted cancer treatment by combining hyperthermia and radiotherapy using Mn-Zn ferrite magnetic nanoparticles［J］.ACS Biomater Sci Eng,2020,6(6):3550-3562.
［37］宋帅，赫丽杰，韩彧佳，等.非小细胞肺癌放疗抵抗研究进展［J］.现代肿瘤医学，2019,27（19）：3520-3523.
SONG Shuai,HE Lijie,HAN Yujia,et al.Advances in radiotherapy resistance of non-small cell lung cancer［J］.Modern Oncology,2019,27（19）：3520-3523.
［38］ GIACOMO D,ANGELO T,PIERSANDRO P.Prussian blue nanoparticles as a versatile photothermal tool［J］.Molecules (Basel,Switzerland),2018,23(6):1414.
［39］ FANG D,LIU Z,JIN H,et al.Manganese-based prussian blue nanocatalysts suppress non-small cell lung cancer growth and metastasis via photothermal and chemodynamic therapy［J］.Front Bioeng Biotechnol,2022,10:939158.
［40］ CHEN Z,LI Z,LI C,et al.Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer［J］.Drug Deliv,2022,29(1):1201-1211.
［41］ ZHAN W,CAI X,LI H,et al.GMBP1-conjugated manganese oxide nanoplates for in vivo monitoring of gastric cancer MDR using magnetic resonance imaging［J］.RSC Adv,2020,10(23):13687-13695.
［42］ LI K,LI P,WANG Y,et al.Manganese-based targeted nanoparticles for postoperative gastric cancer monitoring via magnetic resonance imaging［J］.Front Oncol,2020,10:601538.
［43］ SONG Y,LIU Y,TEO HY,et al.Manganese enhances the antitumor function of CD8(+) T cells by inducing type I interferon production［J］.Cell Mol Immunol,2021,18(6):1571-1574.
［44］ LV M,CHEN M,ZHANG R,et al.Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy［J］.Cell Res,2020,30(11):966-979.
［45］ LIANG Q,CHEN J,HOU S,et al.Activatable Mn(2+)-armed nanoagonist augments antitumor immunity in colorectal cancer:A NIR-II photonic neoadjuvant paradigm［J］.Biomaterials,2023,300:122206.
［46］ CHEN M,LIANG X,GAO C,et al.Ultrasound triggered conversion of porphyrin/camptothecin-fluoroxyuridine triad microbubbles into nanoparticles overcomes multidrug resistance in colorectal cancer［J］.ACS Nano,2018,12(7):7312-7326.
［47］ LIU B,XU T,XU X,et al.Biglycan promotes the chemotherapy resistance of colon cancer by activating NF-κB signal transduction［J］.Mol Cell Biochem,2018,449(1-2):285-294.
［48］ PEI M,LIU K,QU X,et al.Enzyme-catalyzed synthesis of selenium-doped manganese phosphate for synergistic therapy of drug-resistant colorectal cancer［J］.J Nanobiotechnology,2023,21(1):72.
［49］ LIU J,LI L,ZHANG B,et al.MnO(2)-shelled Doxorubicin/Curcumin nanoformulation for enhanced colorectal cancer chemo-immunotherapy［J］.J Colloid Interface Sci,2022,617:315-325.
［50］ KIM SM,IM GH,LEE DG,et al.Mn(2+)-doped silica nanoparticles for hepatocyte-targeted detection of liver cancer in T1-weighted MRI［J］.Biomaterials,2013,34(35):8941-8948.
［51］ XIONG Y,XIAO C,LI Z,et al.Engineering nanomedicine for glutathione depletion-augmented cancer therapy［J］.Chem Soc Rev,2021,50(10):6013-6041.
［52］ TANG H,LI C,ZHANG Y,et al.Targeted manganese doped silica nano GSH-cleaner for treatment of liver cancer by destroying the intracellular redox homeostasis［J］.Theranostics,2020,10(21):9865-9887.
［53］ GOLRA A,KOZLOWSKI M,GUZIK P,et al.The role of selenium and manganese in the formation,diagnosis and treatment of cervical,endometrial and ovarian cancer［J］.International Journal of Molecular Sciences,2023,24(13):10887.
［54］ ZHANG L,CHEN Q,ZOU X,et al.Intelligent protein-coated bismuth sulfide and manganese oxide nanocomposites obtained by biomineralization for multimodal imaging-guided enhanced tumor therapy［J］.J Mater Chem B,2019,7(34):5170-5181.
［55］ ZHU J,LI H,XIONG Z,et al.Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging［J］.ACS Appl Mater Interfaces,2018,10(41):34954-34964.
［56］ HAN C,XIE T,WANG K,et al.Development of fluorescence/MR dual-modal manganese-nitrogen-doped carbon nanosheets as an efficient contrast agent for targeted ovarian carcinoma imaging［J］.J Nanobiotechnology,2020,18(1):175.
［57］ CHEN W,WANG X,ZHAO B,et al.CuS-MnS(2) nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis［J］.Nanoscale,2019,11(27):12983-12989.
［58］ ABBASI AZ,PRASAD P,CAI P,et al.Manganese oxide and docetaxel co-loaded fluorescent polymer nanoparticles for dual modal imaging and chemotherapy of breast cancer［J］.J Control Release,2015,209:186-196.
［59］ XU X,ZHANG R,YANG X,et al.A honeycomb-like bismuth/manganese oxide nanoparticle with mutual reinforcement of internal and external response for triple-negative breast cancer targeted therapy［J］.Adv Healthc Mater,2021,10(18):e2100518.