|Table of Contents|

Neoadjuvant chemotherapy increased postoperative complications of advanced gastric cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3029-3037
Research Field:
Publishing date:

Info

Title:
Neoadjuvant chemotherapy increased postoperative complications of advanced gastric cancer
Author(s):
JIN Zhuanmei1; 2; XU Li3; CHEN Min1; WANG Rui1; AN Yu1; LI Shuangxi1; YUAN Wenzhen1; 2
1.The First Clinical Medical College of Lanzhou University,Gansu Lanzhou 730000,China;2.The First Hospital of Lanzhou University,Gansu Lanzhou 730000，China;3.942 Hospital of People's Liberation Army,Ningxia Yinchuan 750004，China.
Keywords:
gastric cancer; neoadjuvant chemotherapy; radical gastrectomy; postoperative complications; body composition; indicators of inflammation; hematological index; Clavien-Dindo classification
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2024.16.016
Abstract:
Objective:To investigate whether surgery after neoadjuvant chemotherapy increases the incidence and severity of postoperative complications in advanced gastric cancer compared with direct surgery,and to explore the mechanism in terms of body composition and hematological changes.Methods:Clinical data of patients undergoing surgery after neoadjuvant chemotherapy (group A) and patients undergoing direct surgery (group B) in the First Hospital of Lanzhou University from January 2018 to December 2021 were collected by retrospective analysis.The severity of postoperative complications was assessed according to the Clavien-Dindo grading system.First,the differences between the two groups were directly compared,and then the baseline of the two groups was balanced by Propensity Score Matching (PSM).The χ2 test,paired sample t-test,and t-test were used to compare the relationship between classified and continuous data.Results:A total of 302 patients were included.The total incidence of complications in group A (38.4%) was higher than that in group B (30.5%),but the difference was not statistically significant (P＞0.05).Group A was more likely than group B to have serious postoperative complications (P＜0.05).Among the 87 pairs of PSM matched patients,the total complication rate in group A (37.9%) was higher than that in group B (28.7%),but the difference was not statistically significant (P＞0.05).Group A was more likely than group B to have serious postoperative complications (P＜0.05).Meanwhile,compared with group B,muscle density,neutrophil count/lymphocyte count,systemic immunoinflammatory index,platelet count/lymphocyte count,lymphocyte count/monocyte count,prognostic nutrient index,systemic immunoinflammatory nutrient index,hemoglobin,albumin,and platelet in group A after neoadjuvant chemotherapy were significantly decreased (P＜0.05).Conclusion:Surgical treatment of advanced gastric cancer after neoadjuvant chemotherapy is more likely to cause serious postoperative complications than direct surgery,which may be related to the deterioration of body composition,hematological indexes,nutritional indexes and inflammatory indexes before and after neoadjuvant chemotherapy.

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甘肃省卫生健康行业科研计划项目（编号：GSWSKY2022-19）
Last Update: 1900-01-01