|Table of Contents|

Progression on relationship between tumor microenvironment and HER2 targeted drug resistance in breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 15
Page:
2909-2914
Research Field:
Publishing date:

Info

Title:
Progression on relationship between tumor microenvironment and HER2 targeted drug resistance in breast cancer
Author(s):
ZHU JiayuZHANG Qingyuan
Department of Oncology,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China.
Keywords:
breast cancerhuman epidermal growth factor receptor-2tumor microenvironment
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.15.033
Abstract:
Tumor microenvironment provides survival conditions for tumor cells and participates in the invasion and metastasis of malignant tumors.It is highly heterogeneous,dynamic and immunosuppressive.The emergence of anti-HER2 therapy is a milestone in the field of HER2 positive breast cancer treatment.However,the problem of drug resistance can not be ignored,which affects the continuous clinical benefits.It has been recognized that elements of tumor microenvironment can be used as predictors of anti-HER2 therapies in breast cancer as well as play an important role in HER2 targeted drug resistance.We reviewed the mechanism of fibroblasts,adipocytes,immunocytes and cytokines involved in HER2 targeted drug resistance in tumor microenvironment,and the research progression of targeting microenvironment components in the treatment of HER2-positive breast cancer.

References:

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Last Update: 2024-06-28