|Table of Contents|

Advance in the study of HDAC inhibitor Chidamide in hematologic malignancies

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 15
Page:
2903-2909
Research Field:
Publishing date:

Info

Title:
Advance in the study of HDAC inhibitor Chidamide in hematologic malignancies
Author(s):
ZHANG Xiaoqian1WANG Yu2LYU Chengfang1
1.Department of Hematology,Southern University of Science and Technology Hospital,Guangdong Shenzhen 518000,China;2.Department of Hematology,Affiliated Qingdao Central Hospital of Qingdao University,Shandong Qingdao 266000,China.
Keywords:
ChidamideHDAC inhibitorhematologic malignancieslymphomaacute leukemia
PACS:
R733.7
DOI:
10.3969/j.issn.1672-4992.2024.15.032
Abstract:
Epigenetic dysregulation is one of the mechanisms underlying the occurrence and development of hematological malignancies.Histone deacetylase(HDAC) is one of the most characterized epigenetic modifiers,which is critical for regulating gene expression and various signaling pathways.HDAC inhibitor has become a new treatment option for hematological malignancies.Chidamide is a novel subtype selective HDAC inhibitor that can inhibit Class I HDAC1,HDAC2,HDAC3,and Class IIb HDAC10.In 2014,Chidamide alone or in combination with existing therapies was approved by the China Food and Drug Administration as a second-line treatment for relapsed or refractory(R/R) peripheral T-cell lymphoma(PTCL).In recent years,in vitro studies have shown that chidamide affects the regulation of signaling pathways,cell proliferation,apoptosis,and cell cycle.In clinical studies,chidamide has also made significant progress in the treatment of hematological malignancies such as acute leukemiaand multiple myeloma.This article provides a review of the various applications of chidamide in hematological malignancies,including experimental and clinical data of chidamide monotherapy or combination therapy in various hematological malignancies,providing a theoretical basis for further exploration of chidamide.

References:

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Memo

Memo:
南方科技大学医院院长研究基金(编号:2020.A3);南方科技大学医院科研启动经费(编号:2021.002)
Last Update: 2024-06-28