|Table of Contents|

Research progress on the biological mechanism of immunotherapy resistance in renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 15
Page:
2865-2871
Research Field:
Publishing date:

Info

Title:
Research progress on the biological mechanism of immunotherapy resistance in renal cell carcinoma
Author(s):
ZHU LugangLIU Jianjun
Affiliated Hospital of Guangdong Medicial University,Guangdong Zhanjiang 524001,China.
Keywords:
renal cell carcinomaimmunotherapyimmune checkpoint inhibitorsdrug resistance
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2024.15.027
Abstract:
Renal carcinoma is among the most commonly occurring malignancies impacting the urinary system.In recent years,remarkable progress has been achieved intreating kidney cancer by shifting from exclusive utilization of molecularly targeted medications to adopting a combination strategy that incorporates both immune checkpoint inhibitors and molecularly targeted drugs.This integrated therapeutic approach has demonstrated significant advantages for a majority of patients.However,resistance to immunotherapy poses a substantial challenge to achieving optimal clinical efficacy.The objective of this article is to comprehensively examine the fundamental molecular mechanisms accountable for renal cancer's resistance towards immune checkpoint inhibitors while aiming ultimately at identifying innovative therapeutic targets and strategies.

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Memo

Memo:
National Natural Science Foundation of China(No.81272833);国家自然科学基金(编号:81272833)
Last Update: 2024-06-28