|Table of Contents|

The prognostic value of peripheral blood and urinary routine inflammatory markers in patients with advanced urothelial carcinoma treated with PD-1 inhibitors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 15
Page:
2807-2812
Research Field:
Publishing date:

Info

Title:
The prognostic value of peripheral blood and urinary routine inflammatory markers in patients with advanced urothelial carcinoma treated with PD-1 inhibitors
Author(s):
HAO ChaoAI HaitaoZHONG HuamingXU ZhihaoHUANG JiTU Xinhua
Department of Urology,Jiangxi Cancer Hospital/The Second Affiliated Hospital of Nanchang Medical College,Jiangxi Nanchang 330029,China.
Keywords:
urothelial carcinomaprognosisPD-1 inhibitorplateletswhite blood cells
PACS:
R737
DOI:
10.3969/j.issn.1672-4992.2024.15.018
Abstract:
Objective:To investigate the relationship between platelet and white blood cells ratio(PWR),platelet and lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),the urinary leucocyte count(ULEU) and prognosis of patients with advanced urothelial carcinoma(UC) treated with PD-1 inhibitors.Methods:Clinical data of 78 patients with advanced urothelial carcinoma(UC) treated with PD-1 inhibitor were collected,survival rate was calculated by Kaplan-Meier method,Log-rank test was used to compare the differences of survival between different groups,and prognostic factors were analyzed by COX regression analysis.Results:The 1-year survival rates of low PLR group and high PLR group were 71.98% and 47.63%,respectively,with statistically significant differences(P<0.05).The 1-year survival rates of the low NLR group and the high NLR group were 71.36% and 48.15%,respectively,with statistically significant differences(P<0.05).The high PWR group and low PWR group,as well as the status of ULEU,did not demonstrate a significant difference in their ability to predict the survival of patients with UC(P>0.05).Univariate regression analysis revealed that N stage,M stage,TNM stage,number of distant metastasis,PLR and NLR were identified as significant risk factors impacting the survival outcomes of patients with advanced UC(P<0.05).Multivariate regression analysis showed that PLR was an independent factor affecting the prognosis of UC patients treated with PD-1 inhibitors.Conclusion:PLR and NLR are independent factors affecting the prognosis of UC patients.The prognosis of patients with high PLR and high NLR is worse than that of patients with low PLR and low NLR.

References:

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Memo

Memo:
江西省卫生健康委科技计划项目(编号:202211019)
Last Update: 2024-06-28