|Table of Contents|

Research progress on the relationship between kinesin family member 2C and malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2661-2665
Research Field:
Publishing date:

Info

Title:
Research progress on the relationship between kinesin family member 2C and malignant tumors
Author(s):
MENG Qi; ZHOU Yi
Department of Breast Surgery，the First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001，China.
Keywords:
kinesin superfamily proteins; KIF2C; malignant tumor
PACS:
R730.231
DOI:
10.3969/j.issn.1672-4992.2024.14.031
Abstract:
Kinesin superfamily proteins transport organelles,protein complexes and mRNAs in a microtubule and ATP-dependent manner,and are widely involved in tumor cells proliferation,invasion,metastasis,drug resistance and other processes.Kinesin family member 2C,as the most representative member of the Kinesin-13 family,has the function of catalyzing the decomposition of microtubules and is closely involved in multiple processes of mitosis,such as spindle assembly,microtubule dynamics,correction of kinetochore-microtubules attachment,and chromosome location and separation,etc.KIF2C can be used as a potential oncogene in a variety of solid tumors,and its high expression is related to the proliferation,invasion,overall survival and drug resistance of liver cancer,breast cancer,gastric cancer and colorectal cancer.In recent years,the relationship between KIF2C and the occurrence and development of malignant tumors has attracted much attention.KIF2C may be called a potential cancer target.This article summarizes the research progress of KIF2C in malignant tumors.

References:

［1］ BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA Cancer J Clin,2018,68(6):394-424.
［2］ GAO XK,ZHU LH,LU X,et al.KIF15 contributes to cell proliferation and migration in breast cancer［J］.Hum Cell,2020,33(4):1218-1228.
［3］ SUN ZG,PAN F,SHAO JB,et al.Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer［J］.Cancer Cell Int,2020,20(6):5440-5449.
［4］ DING LX,LI B,YU XT,et al.KIF15 facilitates gastric cancer via enhancing proliferation,inhibiting apoptosis,and predict poor prognosis［J］.Cancer Cell Int,2020,20(2):7-34.
［5］ LI XS,HUANG WM,HUANG WB,et al.Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma［J］.Am J Transl Res,2020,12(5):1614-1639.
［6］ ZHANG GP,SHEN SL,YU Y,et al.Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA［J］.J Cell Biochem,2020,121(11):4419-4430.
［7］ WEI S,DAI MM,ZHANG C,et al.KIF2C:a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma［J/OL］.Protein & Cell,2021,12(10):788-809［2021-5-25］.https://doi.org/10.1007/s13238-020-00766-y.
［8］ YANG C,LI Q,CHEN XN,et al.Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation［J］.Aging,2020,12(8):6865-6879.
［9］ ZHOU LH,OUYANG L,CHEN KY,et al.Research progress on KIF3B and related diseases［J］.Ann Transl Med,2019,7(18):492.
［10］ SANHAJI M,FRIEL CT,WORDEMAN L,et al.Mitotic centromere-associated kinesin (MCAK):a potential cancer drug target［J］.OncoTarget,2011,2(12):935-947.
［11］ NAKAMURA Y,TANAKA F,HARAGUCHI N,et al.Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer［J］.Br J Cancer,2007,97(4):543-549.
［12］ 宋世龙,毕明宏,王洪亚,等.Kif2c在非小细胞肺癌组织中的表达及其临床意义［J］.临床肿瘤学杂志,2016,21(06):481-484. SONG SL,BI MH,WANG HY,et al.Expression of Kif2c in non-small cell lung cancer and its clinical significance［J］.Journal of Chinese Clinical Oncology,2016,21(06):481-484.
［13］ CHEN JL,LI S,ZHOU S,et al.Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma［J］.J Cancer Res Ther,2017,13(4):651-659.
［14］ LUCANUS AJ,YIP GW.Kinesin superfamily:roles in breast cancer,patient prognosis and therapeutics［J］.Oncogene,2018,37(7):833-838.
［15］ ISHIKAWA K,KAMOHARA Y,TANAKA F,et al.Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer［J］.Br J Cancer,2008,98(11):1824-1829.
［16］ GWON MR,CHO JH,KIM JR.Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway［J］.FEBS Lett,2012,586(23):4148-4156.
［17］ MOON HH,KREIS NN,FRIEMEL A,et al.Mitotic centromere-associated kinesin (MCAK/KIF2C) regulates cell migration and invasion by modulating microtubule dynamics and focal adhesion turnover［J］.Cancers (Basel),2021,13(22):5673.
［18］ ZHU SL,PAYDAR M,WANG FF,et al.Kinesin Kif2C in regulation of DNA double strand break dynamics and repair［J］.Elife,2020,9:e53402.
［19］ SHIMO A,TANIKAWA C,NISHIDATE T,et al.Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis［J］.Cancer Sci,2008,99(1):62-70.
［20］ LI TF,ZENG HJ,SHAN Z,et al.Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer［J］.Cancer Cell Int,2020,20(12):394-424.
［21］ LIU S,YE Z,XUE VW,et al.KIF2C is a prognostic biomarker associated with immune cell infiltration in breast cancer［J］.BMC Cancer,2023,23(1):307.
［22］ SMITH JC,HUSTED S,PILROSE J,et al.MCAK inhibitors induce aneuploidy in triple negative breast cancer models［J］.BioRxiv,2023,15(3):3309.
［23］ JAYANTHI VSPK SA,DAS AB,SAXENA U.Grade-specific diagnosticand prognostic biomarkers in breast cancer［J］.Genomics,2020,112(1):388-396.
［24］ 张越美,赵洪波,朱亚玲,等.基于数据挖掘分析KIF2C在肝细胞癌的表达及临床意义［J］.重庆医科大学学报,2019,44(11):1454-1457. ZHANG YM,ZHAO HB,ZHU YL,et al.Expression and clinical significance of KIF2C gene in hepatocellular carcinoma:an analysis based on data mining［J］.Journal of Chongqing Medical University,2019,44(11):1454-1457.
［25］ MO S,FANG D,ZHAO S,et al.Down regulated oncogene KIF2C inhibits growth,invasion,and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition［J］.Ann Transl Med.2022,10(3):151.
［26］ ZHANG JJ,LOU WY.A key mRNA-miRNA-lncRNA competing endogenous RNA triple sub-network linked to diagnosis and prognosis of hepatocellular carcinoma［J］.Front Oncol,2020,10:340.
［27］ ZHANG GP,SHEN SL,YU Y,et al.Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA［J］.J Cell Biochem,2020,121(11):4419-4430.
［28］ BAI YQ,XIONG LC,ZHU ML,et al.Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma［J］.Cancer Biomark,2019,24(3):371-382.
［29］ ZENG H,JI JR,SONG XD,et al.Stemness related genes revealed by network analysis associated with tumor immune microenvironment and the clinical outcome in lung adenocarcinoma.［J］.Front Genet,2020,11:549213.
［30］ GAN HZ,LIN L,HU NJ,et al.KIF2C exerts an oncogenic role in non-small cell lung cancer and is negatively regulated by miR-325-3p［J］.Cell Biochem Funct,2019,37(6):424-431.
［31］ LING B,LIAO XJ,HUANG YH,et al.Identification of prognostic markers of lung cancer through bioinformatics analysis and in vitro experiments［J］.Int J Oncol,2020,56(1):193-205.
［32］ ZHAO D,MU HJ,SHI HB,et al.Identification of therapeutic targets and mechanisms of tumorigenesis in non-small cell lung cancer using multiple-microarray analysis［J］.Medicine (Baltimore),2020,99(44):e22815.
［33］ 马艳英,赵冬梅,夏庆欣,等.RELMβ、JAM-A、Kif2c蛋白表达水平与非小细胞肺癌患者病理分期的相关性研究［J］.临床肺科杂志,2018,23(07):1194-1197. MA YY,ZHAO DM,XIA QX,et al.Correlation between pathological staging of non-small cell lung cancer and the expression level of RELMβ,JAM-A and Kif2c［J］.Journal of Clinical Pulmonary Medicine,2018,23(07):1194-1197.
［34］ HUANG R，GAO L．Identification of potential diagnostic and prognostic biomarkers in non-small cell lung cancer based on microarray data［J］． Oncol Lett，2018，15(5):6436-6442．
［35］ GUO J,ZHANG W,SUN L,et al.KIF2C accelerates the development of non-small cell lung cancer and is suppressed by miR-186-3p via the Akt-GSK3β-β-catenin pathway［J］.Sci Rep,2023,13(1):7288.
［36］ 冯雨嘉,蒋佳志,晏鑫,等.使用GEO数据集分析驱动蛋白KIF2C在膀胱癌中的表达及临床意义［J］.转化医学杂志,2019,8(01):15-18. FENG YJ,JIANG JZ,YAN X,et al.Analysis of clinical significance of expression of KIF2C in bladder cancer utilizing GEO datasets［J］.Translational Medicine Journal,2019,8(01):15-18.
［37］ CAI L,SHI B,ZHU K,et al.Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor［J］.Sci Rep,2023,13(1):15404.
［38］ YANG J,WU Z,YANG L,et al.Characterization of kinesin family member 2C as a proto-oncogene in cervical cancer［J］.Front Pharmacol,2022,12:785981.
［39］ CHEN W,LIAO LM,LAI HC,et al.Identification of core biomarkers associated with pathogenesis and prognostic outcomes of laryngeal squamous-cell cancer using bioinformatics analysis［J］.Eur Arch Otorhinolaryngol,2020,277(5):1397-1408.
［40］ GU YQ,LU LF,WU LF,et al.Identification of prognostic genes in kidney renal clear cell carcinoma by RNA-seq data analysis［J］.Mol Med Rep,2017,15(4):1661-1667.
［41］ ZHANG WC,GAO LL,WANG CX,et al.Combining bioinformatics and experiments to identify and verify key genes with prognostic values in endometrial carcinoma ［J］.J Cancer,2020,11(3):716-732.
［42］ VAN DAM PA,ROLFO C,RUIZ R,et al.Potential new biomarkers for squamous carcinoma of the uterine cervix［J］.ESMO Open,2018,3(4):e000352.
［43］ HUANG X,ZHAO F,WU Q,et al.KIF2C facilitates tumor growth and metastasis in pancreatic ductal adenocarcinoma［J］.Cancers (Basel),2023,15(5):1502.
［44］ LIU X,LIN Y,LONG W,et al.The kinesin-14 family motor protein KIF2C promotes prostate cancer progression by regulating p65［J］.J Biol Chem,2023,299(11):105253.
［45］ GANGULY A,YANG HL,CABRAL F.Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel［J］.Mol Cancer Ther,2011,10:929-937.

Memo

Memo:
-
Last Update: 1900-01-01