［1］DE C.Recent developments in radiotherapy［J］.The New England Journal of Medicine,2017,377(11):1065-1075.
［2］WU Y,SONG Y,WANG R,et al.Molecular mechanisms of tumor resistance to radiotherapy［J］.Molecular Cancer,2023,22(1):96.
［3］BARKER HE,PAGET JT,KHAN AA,et al.The tumour microenvironment after radiotherapy:mechanisms of resistance and recurrence［J］.Nat Rev Cancer,2015,15(7):409-425.
［4］LU C,RONG D,ZHANG B,et al.Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma:challenges and opportunities［J］.Molecular Cancer,2019,18(1):130.
［5］WU Q,ZHOU L,LV D,et al.Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression［J］.Journal of Hematology & Oncology,2019,12(1):53.
［6］WANG Z,TANG Y,TAN Y,et al.Cancer-associated fibroblasts in radiotherapy:challenges and new opportunities［J］.Cell Communication and Signaling,2019,17(1):47.
［7］JAROSZ-BIEJ M,SMOLARCZYK R,CICHONT,et al.Tumor microenvironment as a "game changer" in cancer radiotherapy［J］.International Journal of Molecular Sciences,2019,20(13):3212.
［8］XIE F,ZHOU X,FANG M,et al.Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy［J］.Advanced Science,2019,6(24):1901779.
［9］BUZAS EI.The roles of extracellular vesicles in the immune system［J］.Nat Rev Immunol,2023,23(4):236-250.
［10］YU X,HARRIS SL,LEVINE AJ.The regulation of exosome secretion:a novel function of the p53 protein［J］.Cancer Res,2006,66(9):4795-4801.
［11］JABBARI N,NAWAZ M,REZAIE J.Ionizing radiation increases the activity of exosomal secretory pathway in MCF-7 human breast cancer cells:a possible way to communicate resistance against radiotherapy［J］.International Journal of Molecular Sciences,2019,20(15):3649.
［12］BAIETTI MF,ZHANG Z,MORTIER E,et al.Syndecan-syntenin-ALIX regulates the biogenesis of exosomes［J］.Nat Cell Biol,2012,14(7):677-685.
［13］BAGHERI HS,MOUSAVI M,REZABAKHSH A,et al.Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling［J］.Lasers in Medical Science,2018,33(5):1131-1145.
［14］HOSHINO A,COSTA-SILVA B,SHEN TL,et al.Tumour exosome integrins determine organotropic metastasis［J］.Nature,2015,527(7578):329-335.
［15］NAKAOKA A,NAKAHANA M,INUBUSHI S,et al.Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species［J］.Oncology Reports,2021,45(4):13.
［16］HAZAWA M,TOMIYAMA K,SAOTOME-NAKAMURA A,et al.Radiation increases the cellular uptake of exosomes through CD29/CD81 complex formation［J］.Biochemical and Biophysical Research Communications,2014,446(4):1165-1171.
［17］QIAN J,YANG J,DRAGOVIC AF,et al.Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2［J］.Cancer Research,2005,65(13):5493-5497.
［18］TU C,DU Z,ZHANG H,et al.Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells［J］.Theranostics,2021,11(5):2364-2380.
［19］ABRAMOWICZ A,LABAJ W,MIKA J,et al.MicroRNA profile of exosomes and parental cells is differently affected by ionizing radiation［J］.Radiation Research,2020,194(2):133-142.
［20］ABRAMOWICZ A,WOJAKOWSKA A,MARCZAK L,et al.Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro［J］.Journal of Radiation Research,2019,60(3):289-297.
［21］ZHANG MX.Exosomes from irradiated hepatocellular carcinoma cells induced DNA damage of tumor cells and enhanced dendritic cells mediated anti-tumor immunity［D］.Hefei:Anhui Medical University,2021.
［22］MUTSCHELKNAUS L,AZIMZADEH O,HEIDER T,et al.Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells［J］.Scientific Reports,2017,7(1):12423.
［23］BUSSON P,MUTSCHELKNAUS L,PETERS C,et al.Exosomes derived from squamous head and neck cancer promote cell survival after ionizing radiation［J］.PLoS One,2016,11(3):e0152213.
［24］TORTOLICI F,VUMBACA S,INCOCCIATI B,et al.Ionizing radiation-induced extracellular vesicle release promotes AKT-associated survival response in SH-SY5Y neuroblastoma cells［J］.Cells,2021,10(1):107.
［25］JIANG MJ,CHEN YY,DAI JJ,et al.Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer［J］.Mol Cancer,2020,19(1):68.
［26］TANG Y,CUI Y,LI Z,et al.Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells［J］.J Exp Clin Cancer Res,2016,35:7.
［27］RAMAKRISHNAN V,XU B,AKERS J,et al.Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas［J］.EBioMedicine,2020,55:102736.
［28］LI Y,HUANG L,CHEN Y,et al.Irradiated cell-derived exosomes transmit essential molecules inducing radiation therapy resistance［J］.International Journal of Radiation Oncology,Biology,Physics,2022,113(1):192-202.
［29］DIAMOND JM,VANPOUILLE-BOX C,SPADA S,et al.Exosomes shuttle TREX1-sensitive IFN-stimulatory dsDNA from irradiated cancer cells to DCs［J］.Cancer Immunol Res,2018,6(8):910-920.
［30］JELLA KK,NASTI TH,LI Z,et al.Exosome-containing preparations from postirradiated mouse melanoma cells delay melanoma growth in vivo by a natural killer cell-dependent mechanism［J］.International Journal of Radiation Oncology,Biology,Physics,2020,108(1):104-114.
［31］MIN H,SUN X,YANG X,et al.Exosomes derived from irradiated esophageal carcinoma-infiltrating T cells promote metastasis by inducing the epithelial-mesenchymal transition in esophageal cancer cells［J］.Pathol Oncol Res,2018,24(1):11-18.
［32］ZHENG Y,LIU L,CHEN C,et al.The extracellular vesicles secreted by lung cancer cells in radiation therapy promote endothelial cell angiogenesis by transferring miR-23a［J］.PeerJ,2017,5:e3627.
［33］DATTA A,KIM H,LAL M,et al.Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells［J］.Cancer Letters,2017,408:73-81.
［34］DATTA A,KIM H,MCGEE L,et al.High-throughput screening identified selective inhibitors of exosome biogenesis and secretion:a drug repurposing strategy for advanced cancer［J］.Scientific Reports,2018,8(1):8161.
［35］NISHIDA-AOKI N,TOMINAGA N,TAKESHITA F,et al.Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis［J］.Molecular Therapy,2017,25(1):181-191.
［36］ORTIZ A,GUI J,ZAHEDI F,et al.An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles［J］.Cancer Cell,2019,35(1):33-45.e36.
［37］DU X,ZHANG X,DONG J,et al.Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC［J］.Journal of Translational Medicine,2022,20(1):507.
［38］MA X,YAO M,GAO Y,et al.Functional immune cell-derived exosomes engineered for the trilogy of radiotherapy sensitization［J］.Advanced Science,2022,9(23):e2106031.
［39］TIAN T,LIANG R,EREL-AKBABA G,et al.Immune checkpoint inhibition in GBM primed with radiation by engineered extracellular vesicles［J］.ACS Nano,2022,16(2):1940-1953.
［40］LUO A,ZHOU X,SHI X,et al.Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma［J］.Oncogene,2019,38(25):4990-5006.