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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 14

Page:

2647-2651

Research Field:

Publishing date:

Info

Title:

Exploring the biomolecular mechanism of reduced graphene oxide in the treatment of cancer

Author(s):

WU Jianze¹; 2; WANG Dequan¹; 2; CHEN Huiguang¹; 2; LI Jia¹; 2; WU Qingming¹; 3

1.Institute of Infection,Immunity and Tumor Microenvironment,School of Medicine,Wuhan University of Science and Technology,Hubei Wuhan 430065,China;2.Hubei Key Laboratory of Occupational Hazard Identification and Control,Hubei Wuhan 430065,China;3.Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Hubei Wuhan 430064,China.

Keywords:

reduced graphene oxide; nanomaterials; cancer therapy; molecular mechanisms

PACS:

R730.5

DOI:

10.3969/j.issn.1672-4992.2024.14.028

Abstract:

Reduced graphene oxide is a two-dimensional carbon-based nanomaterial with good biocompatibility,hydrophobicity,mechanical properties,electrical conductivity,and good surface modification for surface functionalization under biological conditions,which can assist in cancer therapy through biosensors,drug loading and targeted delivery,and also participate in various signaling networks in living organisms through their physical properties or functional group interactions with cells,and therefore has a promising future in cancer therapy.Many studies have shown that rGO is involved in the activation or inhibition of cancer-related signaling pathways and alteration of molecular signaling,and this paper summarizes and outlines the role of rGO in the complex molecular mechanisms of cancer therapy,and outlines the ways in which it can cause mitochondrial dysfunction,apoptosis,induce inflammation,lead to cellular autophagy,affect cancer metastasis,and enhance the anticancer activity of other nanomaterials to induce cancer cell death.

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Memo

Memo:

National Natural Science Foundation of China(No.81573239£©£»¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð£¨±àºÅ£º81573239£©£»ºþ±±Ê¡ÎÀÉú½¡¿µÎ¯Ô±»á¿ÆÑлù½ð£¨±àºÅ£ºWJ2019M256£©

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