|Table of Contents|

Spindle and KT associated 2(SKA2):A universal tumour biomarker and a potential therapeutical target

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2641-2646
Research Field:
Publishing date:

Info

Title:
Spindle and KT associated 2(SKA2):A universal tumour biomarker and a potential therapeutical target
Author(s):
CEN MeizhiGAO LuREN Mingqiang
Department of Hematology,Affiliated Hospital of Zunyi Medical University,Guizhou Zunyi 563000,China.
Keywords:
SKA2the spindle and kinetochore associated complextumor
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2024.14.027
Abstract:
SKA2 protein is a part of the spindle and kinetochore associated (SKA) complex,which plays a critical role in the maintenance of the metaphase plate and spindle checkpoint silencing during mitosis.It is involved in the regulation of cell cycle,and affects cell proliferation and apoptosis by glucocorticoid receptor,p53 and other pathways,which is closely associated with tumorigenesis.Studies have shown that SKA2 is an oncogene that is highly expressed in a variety of malignant tumors and promotes the occurrence and development of tumors.This review focuses on discussing the regulation,biological functions and clinical importance of SKA2 in human cancers.

References:

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