|Table of Contents|

Comparative analysis of DBT imaging and clinicopathological features of ultrasonically suspected ductal carcinoma in situ with micro-invasion and ductal carcinoma in situ

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2606-2614
Research Field:
Publishing date:

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Title:
Comparative analysis of DBT imaging and clinicopathological features of ultrasonically suspected ductal carcinoma in situ with micro-invasion and ductal carcinoma in situ
Author(s):
LI Hongen; TANG Dawei; CHENG Jialing; LIN Xing; ZENG Yihui; WANG Xia
Department of Radiology,Guangdong Province Hospital for Women and Children Healthcare，Guangdong Guangzhou 510000,China.
Keywords:
digital breat tomosynthesis; ductal carcinoma in situ; ductal carcinoma in situ with micro-invasion; clinicopathologic findings
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.14.020
Abstract:
Objective:In the case of ultrasonography for suspicious breast lesions,digital breast tomosynthesis (DBT) was performed to study the differences in DBT imaging between ductal carcinoma in situ with micro-invasion (DCIS-Mi) and ductal carcinoma in situ (DCIS),as well as the related clinicopathological manifestations,and to explore the predictors of DCIS-Mi.Methods:The clinical,pathological,and DBT imaging data of 124 patients with postoperative pathologically confirmed DCIS in our hospital from January 2019 to November 2022 were retrospectively analyzed,including 79 patients with pure DCIS (63.71%) and 45 patients with DCIS-Mi (36.29%).The DBT images of the two groups were analyzed in detail with reference to BI-RADS (breast imaging reporting and data system).χ2 test or Fisher exact probability method were used to compare the differences between DBT imaging features and clinicopathological findings between the two groups.Multivariate Logistic regression analysis was used to study the risk factors associated with DCIS-Mi.Results:Therefore,among the patients,the main initial clinical symptoms were touching mass in 81 cases (65.32%),nipple discharge in 31 cases (25.00%),and calcification in 12 cases (9.68%).Through the clinicopathological examination of the two groups of patients,we can see that there are significant differences in their nuclear atypia (χ2=7.967,P=0.005).However,other factors,such as age,menopause,initial clinical symptoms,lymph node status,immunohistochemical markers (ER,PR,HER-2,Ki-67) and the category of pathological molecular substances,were not significant in the two groups (P＞0.05).In the DBT image features,there were statistically significant differences in the maximum diameter,shape and marginal burr signs between the two lesions (χ2 were 4.055,6.687,4.755,P＜0.05).There were no significant differences in gland type,lesion type,microcalcification,calcification morphology and calcification distribution (P＞0.05).Multivariate Logistic regression analysis of tumor size,tumor shape and marginal burr sign did not constitute the risk factors for DCIS-Mi.Conclusion:There are differences between DCIS-Mi and DCIS in clinicopathology and DBT imaging.Most DCIS-Mi lesions are mass with maximum diameter ≥ 2.5 cm,irregular shape,uneven edges and burr signs.In addition,DCIS-Mi was more malignant.In terms of pathology,the tumors of DCIS-Mi were mainly HER-2 overexpression type,and the nuclear atypia was mainly concentrated in the middle and high grade.The prognosis is poor.

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