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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 14

Page:

2506-2511

Research Field:

Publishing date:

Info

Title:

Dopamine-modified hydrogels loaded with cisplatin inhibit the proliferation of KRAS mutant lung cancer cells

Author(s):

LIU Zhijin¹; ZHANG Jian¹; GAN Lin¹; LYU Xiaobin¹; 2; ZHANG Weihua³; XU Jun¹

1.Department of Oncology,the Third Affiliated Hospital of Nanchang University-the First Hospital of Nanchang,Jiangxi Nanchang 330008,China;2.The Key Laboratory of Tumor Metastasis and Precision Treatment in Jiangxi Province,Jiangxi Nanchang 330008,China;3.Department of Integrative Medicine,the First Affiliated Hospital of Nanchang Medical College-Jiangxi Provincial People's Hospital,Jiangxi Nanchang 330000,China.

Keywords:

lung cancer; hydrogel; dopamine; cisplatin; KRAS mutant

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2024.14.002

Abstract:

Objective:To investigate the effect of dopamine-modified hydrogel loaded with cisplatin on the proliferation of KRAS mutant lung cancer cells.Methods:Polyvinylpyrrolidone (PVP) and chitosan were used to synthesize hydrogel for injection,and dopamine was introduced to form modified hydrogel by chemical crosslinking method.The swelling,biosafety and drug-carrying capacity of dopamine-modified hydrogel were studied by cell co-culture.The effect of dopamine-modified hydrogel loaded with cisplatin on the proliferation of KRAS mutant lung cancer cells was studied in vitro co-culture.The inhibitory effect of dopamine-modified hydrogel loaded with cisplatin on the proliferation of xenografted tumor in nude mice was studied.Results:The dopamine-modified hydrogel has strong swelling property,good biosafety,strong drug load and release ability and sensitive pH tissue environment recognition ability.The dopamine-modified hydrogel loaded with cisplatin has a stronger inhibitory effect on the proliferation of KRAS mutant lung cancer cells in vitro and in vivo than that of cisplatin alone.Conclusion:The combination of traditional chemotherapy drugs and dopamine-modified hydrogels has stronger anti-tumor effect,which may provide a new solution for anti-tumor therapy in the future.

References:

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Memo

Memo:

2023年江西省卫生健康委科技计划项目（编号：202311199）

Common functions

Last Update: 1900-01-01