|Table of Contents|

Effect of cachexia index on major postoperative complications and hospitalization costs in patients with Siewert type II adenocarcinoma of esophagogastric junction

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 24
Page:
4561-4567
Research Field:
Publishing date:

Info

Title:
Effect of cachexia index on major postoperative complications and hospitalization costs in patients with Siewert type II adenocarcinoma of esophagogastric junction
Author(s):
ZHANG Liao; WANG Cheng; FENG Zewei; ZHOU Zhisen; ZHENG Shiming; BAN Bingbing; ZHANG Meng
Department of Thoracic Surgery,the Second Hospital of Lanzhou University,the Second Clinical College of Lanzhou University,Gansu Lanzhou 730030,China.
Keywords:
Siewert type II adenocarcinoma of esophagogastric junction; cachexia index; cachexia; main complications; hospitalization costs
PACS:
R735
DOI:
10.3969/j.issn.1672-4992.2023.24.014
Abstract:
Objective:To evaluate the effect of cachexia index (CXI) on major postoperative complications and hospitalization costs in patients with Siewert type II adenocarcinoma of the esophagogastric junction.Methods:The clinical data of 586 patients with Siewert type Ⅱ adenocarcinoma of esophagogastric junction admitted to our hospital were retrospectively collected from October 2018 to March 2023.The CXI was calculated by combining the skeletal muscle area of the third lumbar spine,preoperative albumin and neutrophil-lymphocyte ratio.The critical value was determined according to the ROC curve and Youden index of the main complications.The patients were divided into high CXI group and low CXI group.The clinical data of the two groups was analyzed.Univariate and multivariate logistic regression were used to analyze the independent risk factors for major complications (Clavien-Dindo grade≥III) and increased hospitalization costs in patients with Siewert type II adenocarcinoma of the esophagogastric junction.Results:The incidence of major complications was higher in the low CXI group (10.1% vs 2.1%,P＜0.001).Postoperative hospital stay was longer ［(14.21±8.22)d vs (12.55±5.09)d,P=0.003］.The hospitalization cost was higher ［(78 286.42±32 118.59)yuan vs (69 804.38±16 654.53)yuan,P＜0.001］.In multivariate logistic regression analysis,CXI (OR=4.903,95%CI:1.974~12.176,P＜0.001) and cachexia (OR=4.636,95%CI:1.823~11.790,P=0.001) were independent risk factors for major complications.NLR (OR=1.916,95%CI:1.040~3.529,P=0.037),cachexia (OR=1.620,95%CI:1.115~2.354,P=0.011),anemia (OR=2.219,95%CI:1.289~3.516,P=0.003),chronic obstructive pulmonary disease (OR=3.505,95%CI:1.321~9.300,P=0.012) and major complications (OR=21.121,95%CI:6.168~72.322,P＜0.001) were independent risk factors for increased hospitalization expenses.Conclusion:Low CXI predicts an increased risk of major postoperative complications and increased hospitalization costs in patients with Siewert type II adenocarcinoma of the esophagogastric junction.It is recommended to calculate the cachexia index before operation and use it as an important index to evaluate the main postoperative complications and hospitalization expenses of patients.

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Memo

Memo:
甘肃省自然科学基金资助项目(编号：21JR7RA405)；兰州大学第二医院“萃英科技创新”计划（编号：CY2020-MS11）
Last Update: 1900-01-01