|Table of Contents|

Anti-tumor immunotherapy strategy based on tumor associated macrophages

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 23
Page:
4455-4462
Research Field:
Publishing date:

Info

Title:
Anti-tumor immunotherapy strategy based on tumor associated macrophages
Author(s):
LUO Ruhua1LIAO Xiujun23
1.Department of Pharmacy,Wuhan Hankou Hospital,Hubei Wuhan 430012,China;2.Department of Colorectal Surgery and Oncology,Key Laboratory of Cancer Prevention and Intervention,Ministry of Education,the Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Hangzhou 310058,China;3.Cancer Center,Zhejiang University,Zhejiang Hangzhou 310058,China.
Keywords:
tumor microenvironmenttumor associated macrophageimmunotherapytherapeutic targettumor therapy
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2023.23.031
Abstract:
Tumor associated macrophages (TAMs),the most widely infiltrated immune cells in the tumor microenvironment (TME),have complex and diverse biological roles to promote tumor invasion and metastasis,tumor angiogenesis,and the construction of suppressive tumor microenvironment.Furthermore,given these key roles to develop potential therapeutic strategies became an emerging cancer research hotspot.The paper summarizes the impact of polarization of TAMs on TME,as well as the functional diversity of TAMs such as inhibition and plasticity,and focuses on reviewing the recent research advances on TAMs in drug development and clinical trials.Finally,new technologies and approaches to tumor immunotherapy are discussed with the aim of providing new options for tumor treatment and strategies to maximize therapeutic benefit by better deciphering the TME.

References:

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Memo:
浙江省自然科学基金(编号:LY21H270016)
Last Update: 2023-10-31