|Table of Contents|

The auxiliary diagnostic value of tumor markers level in benign and malignant pleural effusion when the nature of exfoliated cells is unclear

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 23
Page:
4367-4371
Research Field:
Publishing date:

Info

Title:
The auxiliary diagnostic value of tumor markers level in benign and malignant pleural effusion when the nature of exfoliated cells is unclear
Author(s):
CHEN Wenbo1; XU Maoyi2; SONG Binbin1
1.Graduate School of Bengbu Medical College，Anhui Bengbu 233030，China；2.Department of Oncology,The First Hospital of Jiaxing,Zhejiang Jiaxing 314000,China.
Keywords:
lung cancer; pleural effusion; exfoliative cytology; tumor markers
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2023.23.013
Abstract:
Objective:To investigate the value of five pleural effusion tumor markers［carcinoembryonic antigen(CEA),carbohydrate antigen CA199,carbohydrate antigen CA242,carbohydrate antigen CA50,cytokeratin 19 fragment antigen 21-1(CYFRA21-1)］ in the diagnosis of benign and malignant pleural effusion when the exfoliated cells were not clear.Methods:A total of 261 patients with pleural effusion from January 2020 to June 2022 were collected,including 88 patients with benign pleural effusion,93 patients with malignant pleural effusion,and 80 patients with negative exfoliated cells.The levels and positive rates of five tumor markers in pleural effusion of the three groups were compared,and the differential ability of different tumor markers alone and in combination was analyzed.Results:There were significant differences in the levels of five tumor markers among the three groups(P＜0.01).The level of CEA in positive group was higher than that in negative group and benign group(P＜0.01).The level of CEA in negative group was higher than that in benign group(P＜0.01).The levels of CEA and CYFRA21-1 in the pleural effusion shedding positive group were higher than those in the serum positive group(P＜0.01).The level of CYFRA21-1 in seronegative group was higher than that in seronegative group(P＜0.01).There were significant differences in the positive rate of CYFRA21-1 among the three groups(P＜0.01).The positive rates of CEA,CA199,CA242 and CA50 in the pleural effusion positive group were higher than those in the negative and benign groups(P＜0.01).The positive rates of CEA,CA199,CA242 and CA50 in the negative group were higher than those in the benign group(P＜0.01).There was no significant difference in the positive rate of CYFRA21-1 among the three groups(P＞0.05).The diagnostic efficacy of CEA in pleural effusion shedding positive and negative groups was better than that of other groups alone.The combined detection of CEA+CYFRA21-1 in the dropped positive group and CEA+CA50 in the dropped negative group can improve the differentiation ability.Conclusion:The levels of tumor markers in pleural effusion have important auxiliary value in the diagnosis of benign and malignant pleural effusion when the nature of exfoliated cells is unclear.

References:

[1] SHAFIQ M,FELLER-KOPMAN D.Management of malignant pleural effusions ［J］.Clin Chest Med,2020,41(2):259-267.
[2] SIEGEL RL,MILLER KD,FUCHS HE,et al.Cancer statistics,2022 ［J］.CA Cancer J Clin,2022,72(1):7-33.
[3] FENG M,ZHU J,LIANG LQ,et al.Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion:a validation study and meta-analysis ［J］.Int J Clin Oncol,2017,22(2):283-290.
[4] WANG SF,TIAN S,LI Y,et al.Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion ［J］.EBioMedicine,2020,58(1):325-332.
[5] KASSIRIAN S,HINTON SN,CUNINGHAME S,et al.Diagnostic sensitivity of pleural fluid cytology in malignant pleural effusions:systematic review and meta-analysis ［J］.Thorax,2023,78(1):32-40.
[6] ZHANG H,LI CH,HU F,et al.Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion ［J］.Respir Res,2020,21(1):284.
[7] LOMBARDI G,ZUSTOVICH F,NICOLETTO MO,et al.Diagnosis and treatment of malignant pleural effusion:a systematic literature review and new approaches ［J］.Am J Clin Oncol,2010,33(4):420-423.
[8] 丁兴龙,张先娥,郭继强.7项肿瘤标志物检测对胸腔积液良恶性的鉴别价值［J］.检验医学与临床,2022,19(08):1057-1060. DING XL,ZHANG XE,GUO JQ.The differential value of seven tumor markers in benign and malignant pleural effusion［J］.Lab Med & Clin,2022,19(08):1057-1060.
[9] CHEN C,YANG YG,YANG W,et al.The diagnostic value of CEA for lung cancer-related malignant pleural effusion in China:a meta-analysis ［J］.Expert Rev Respir Med,2022,16(1):99-108.
[10] OKAMURA K,TAKAYAMA K,IZUMI M,et al.Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer ［J］.Lung Cancer,2013,80(1):45-49.
[11] RODRIGUEZ-PANADERO F,BORDERAS NARANJO F,LOPEZ MEJIAS J.Pleural metastatic tumours and effusions.Frequency and pathogenic mechanisms in a post-mortem series ［J］.Eur Respir J,1989,2(4):366-369.
[12] CHEN ZQ,WANG Y,FANG M.Analysis of tumor markers in pleural effusion and serum to verify the correlations between serum tumor markers and tumor size,TNM stage of lung adenocarcinoma ［J］.Cancer Med,2020,9(4):1392-1399.
[13] PSALLIDAS I,KALOMENIDIS I,PORCEL JM,et al.Malignant pleural effusion:from bench to bedside ［J］.Eur Respir Rev,2016,25(140):189-198.
[14] 吴娟,郑丹,阮丽蒽.多项肿瘤标志物联合检测在胃肠道肿瘤诊断中的价值［J］.标记免疫分析与临床,2020,27(01):10-14,18. WU J,ZHENG D,RUAN LE.Value of combined detection of multiple tumor markers in the diagnosis of gastrointestinal tumors［J］.Marker Immunoassay & Clinic,2020,27(01):10-14,18.
[15] CHEN ZQ,HUANG LS,ZHU B.Assessment of seven clinical tumor markers in diagnosis of non-small-cell lung cancer ［J］.Dis Markers,2018,28(2):580-586.
[16] 周建平，宋晓龙，王改琴，等.五种肿瘤标志物联检在小细胞肺癌诊断中的价值［J］.现代肿瘤医学，2021，29（15）：2635-2638. ZHOU JP,SONG XL,WANG GQ,et al.The value of diagnosis of small cell lung cancer with combined detection of five tumor markers［J］. Modern Oncology,2021，29（15）：2635-2638.

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浙江省嘉兴市科技计划项目（编号：2019AY32030）
Last Update: 2023-10-31