|Table of Contents|

Progress in clinical diagnosis and treatment of light chain deposition disease

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 21
Page:
4050-4054
Research Field:
Publishing date:

Info

Title:
Progress in clinical diagnosis and treatment of light chain deposition disease
Author(s):
SHEN Yang; ZHANG Lihong
Department of Hematology,the First Hospital of Hebei Medical University,Hebei Shijiazhuang 050031,China.
Keywords:
light chain deposition disease; monoclonal light chains; monoclonal gammopathy of renal significance; free light chain; daratumumab; CyBorD; diagnosis; treatment
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2023.21.028
Abstract:
Light chain deposition disease(LCDD) is the most common monoclonal immunoglobulin deposition disease.Excessive monoclonal immunoglobulin light chain is secreted by plasma cells or B lymphocytes and deposited in tissues,resulting in organ dysfunction.LCDD is a systemic disease with multiple organ involvement led by kidney.Introduced from the connotation and extension of LCDD,this paper summarizes the progress of clinical diagnosis and treatment of LCDD in recent years from the aspects of clinical manifestations and evaluation of organ system involvement,pathological characteristics and diagnosis,hematological characteristics and detection,treatment strategies and protocols.

References:

[1] SWERDLOW SH,CAMPO E,HARRIS NL,et al.WHO classification of tumours of haematopoietic and lymphoid tissues［M］.Revised 4th ed,Lyon:IARC Press,2017:255-257.
[2] LEUNG N,BRIDOUX F,BATUMAN V,et al.The evaluation of monoclonal gammopathy of renal significance:a consensus report of the International Kidney and Monoclonal Gammopathy Research Group［J］.Nat Rev Nephrol,2019,15(1):45-59.
[3] CRISTINO A,PAIS C,SILVA R,et al.Light-chain deposition disease with prominent hepatic involvement［J］.Eur J Case Rep Intern Med,2017,4(3):000545.
[4] HUDAK M,SARDANA R,PARWANI AV,et al.Light chain deposition disease presenting as an atrial mass:a case report and review of literature［J］.Cardiovasc Pathol,2021,55(2):107368.
[5] 李沂蔓,刘春梅,杨亦彬.轻链沉积性肾病误诊为高血压肾病一例并文献复习［J］.海南医学,2020,31(2):256-258.LI YM,LIU CM,YANG YB.Light chain deposition nephropathy misdiagnosed as hypertensive nephropathy:a case report and literature review［J］.Hainan Med J,2020,31(2):256-258.
[6] MIZUNO S,KITAYAMA C.Light chain deposition disease without proteinuria［J］.eJHaem,2020,1(2):409-410.
[7] LIN ZS,ZHANG X,LI DY,et al.Clinicopathological features and outcomes of coexistent light chain cast nephropathy and light chain deposition disease in patients with newly diagnosed multiple myeloma［J］.Journal of Clinical Pathology,2022,75:668-674.
[8] TU H,MOU L,ZHU L,et al.Acquired Fanconi syndrome secondary to light chain deposition disease associated with monoclonal gammopathy of renal significance:a case report［J］.Medicine,2018,97(36):e12027.
[9] SHAO L,JIANG W,WANG W,et al.Concurrent non-crystalline light chain proximal tubulopathy and light chain deposition disease:a case report［J］.Nephrology,2021,26(5):485-486.
[10] GREMBIALE A,GARLATTI E,ERMACORA A,et al.An unusual case of cholestatic hepatitis due to light-chain deposition disease［J］.Case Rep Oncol,2020,13(3):1343-1348.
[11] WANG Z,ZHANG H.Spontaneous diffuse bleeding of the gastrointestinal tract in a patient with light-chain deposition disease［J］.Int J Clin Exp Med,2019,12(1):1142-1146.
[12] COHEN C,JOLY F,SIBILLE A,et al.Randall-type monoclonal immunoglobulin deposition disease:new insights into the pathogenesis,diagnosis and management［J］.Diagnostics,2021,11(3):420.
[13] ROMANO A,RISO V,BISOGNI G,et al.Isolated light chain deposition disease neuropathy in a patient with multiple myeloma［J］.Amyloid,2020,27(1):67-68.
[14] MATJASIC A,WECHTERSBACH K,KAVALAR R,et al.Brain aggregoma with clonal B-cell perivascular proliferation detected by next-generation sequencing.A case report and review of the literature［J］.Folia Neuropathol,2021,59(2):205-211.
[15] WEI P,TAO R,LIU Y,et al.Pulmonary light chain deposition disease:a case series and literature review［J］.Ann Transl Med,2020,8(9):588.
[16]］ DELAEY P,PLAWNY L,NCHIMI A,et al.Effect of surgery of pulmonary cysts related to immunoglobulin light chain deposits［J］.Rev Mal Respir,2020,37(2):180-186.
[17] CLAYDEN RC,MACDONALD D,OIKONOMOU A,et al.Cystic lung disease with kappa light chain deposition in newly diagnosed multiple myeloma［J］.Br J Haematol,2019,188(2):201.
[18] KUNNATH-VELAYUDHAN S,LARSEN BT,COLEY SM.Masson trichrome and sulfated alcian blue stains distinguish light chain deposition disease from amyloidosis in the lung［J］.Am J Surg Pathol,2021,45(3):405-413.
[19] PONTES DOS SANTOS L,COUTO J,ROMANO M,et al.Light-chain deposition disease presenting with spontaneous splenic rupture［J］.Eur J Case Rep Intern Med,2018,5(12):001010.
[20] WANG Q,JIANG F,XU G.The pathogenesis of renal injury and treatment in light chain deposition disease［J］.J Transl Med,2019,17:387.
[21] TSUSHIMA T,SUZUKI T,TERAO T,et al.Light chain deposition disease involving kidney and liver in a patient with IgD myeloma［J］.BMC Nephrol,2021,22(1):40.
[22] 徐剑,刘欢.硫酸阿尔新蓝染色方法介绍［J］.临床与实验病理学杂志,2019,35(9):1119-1120.XU J,LIU H.Introduction of Alcian blue sulfate dyeing method［J］.J Clin Exp Pathol,2019,35(9):1119-1120.
[23] ABILDGAARD N,ROJEK AM,MLLER HE,et al.Immunoelectron microscopy and mass spectrometry for classification of amyloid deposits ［J］.Amyloid,2020,27(1):59-66.
[24] SOBUE Y,TAKEMURA G,KAWAMURA S,et al.Coexistence of amyloidosis and light chain deposition disease in the heart［J］.Cardiovasc Pathol,2021,51:107315.
[25] LIN ZS,YU XJ,QIN AB,et al.Coexistent light chain deposition disease,light chain cast nephropathy,and vascular light chain amyloidosis in a patient with IgD lambda multiple myeloma［J］.Int Urol Nephrol,2021,53(8):1729-1731.
[26] ALONSO-TITOSA J,MARTNEZ-ESTEBANA MD,LPEZ V,et al.Monoclonal gammopathy of renal significance:early diagnosis is key［J］.Nefrología,2021,41(5):502-513.
[27] KASTRITIS E,ROUSAKIS P,KOSTOPOULOS IV,et al.Consolidation with a short course of daratumumab in patients with AL amyloidosis or light chain deposition disease［J］.Amyloid,2021,28(4):259-266.
[28] RENDO M,FRANKS TJ,GALVIN JR,et al.Autologous stem cell transplantation in the treatment of pulmonary light chain deposition disease［J］.Chest,2021,160(1):13-17.
[29] LOMAS OC,MOUHIEDDINE TH,TAHRI S,et al.Monoclonal gammopathy of undetermined significance(MGUS)-not so asymptomatic after all［J］.Cancers,2020,12(6):1554.
[30] MEN P,ALEXANDRIS LD,MOIOLI A,et al.Monoclonal gammopathies of renal significance:renal biopsy and beyond［J］.Cancers,2020,12(7):1741.
[31] PEA C,SCHUTZ NP,RIVA E,et al.Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance-related lesions in Latin America［J］.Nephrology,2020,25(6):442-449.
[32] FLORENT JOLY F,COHEN C,JAVAUGUE V,et al.Randall-type monoclonal immunoglobulin deposition disease:novel insights from a nationwide cohort study［J］.Blood,2019,133(6):576-587.
[33] COHEN C,ROYER B,JAVAUGUE V,et al.Bortezomib produces high hematological response rates with prolonged renal survival in monoclonal immunoglobulin deposition disease［J］.Kidney Intern,2015,88(5):1135-1143.
[34] DUTTA A,KESARI K,SINGH T.Cyclophosphamide,bortezomib and dexamethasone(CyBorD):a promising regimen for renal light chain deposit disease［J］.BMJ Case Rep,2020,13(1):e232985.
[35] KIMURA S,OHKAWARA H,OGAWA K,et al.Lenalidomide as a beneficial treatment option for renal impairment caused by light chain deposition disease［J］.Intern Med,2018,57(24):3651-3657.
[36] MILANI P,BASSET M,CURCI P,et al.Daratumumab in light chain deposition disease:rapid and profound hematologic response preserves kidney function［J］.Blood Adv,2020,4(7):1321-1324.
[37] WIKLIK-DZIADEK M,JAWOREK-TROC J,JURCZYSZYN A.Amyloidosis,extramedullary plasmacytoma,and light chain deposition disease:impressive results of daratumumab therapy［J］.Pol Arch Intern Med,2021,131(3):297-298.
[38] ABDALLAH AA,ALAPAT D,KAUR V,et al.Outcomes of autologous stem cell transplant for cardiac AL-amyloidosis and cardiac light chain deposition disease［J］.J Oncol Pharm Pract,2020,26(5):1128-1133.
[39] 王伊娜,董葆,杨洪杰,等.血液滤过吸附治疗用于多发性骨髓瘤轻链清除1例［J］.中国血液净化,2018,17(2):137-140.WANG YN,DONG B,YANG HJ,et al.Hemo-filtrate-reinfusion for light chain clearance of multiple myeloma:a case report［J］.Chin J Blood Purif,2018,17(2):137-140.
[40] AOUDIA R,BACHA MM,OUNISSI M,et al.Monoclonal gammopathy of renal significance with light-chain deposition disease in kidney transplantation［J］.Saudi J Kidney Dis Transpl,2019,30(5):1161-1165.

Memo

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河北省卫生健康委医学科学研究课题（编号：20201150）
Last Update: 2023-09-28