|Table of Contents|

Relationship between ABCG2 and microRNA gene polymorphism and susceptibility to nasopharyngeal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 21
Page:
3951-3956
Research Field:
Publishing date:

Info

Title:
Relationship between ABCG2 and microRNA gene polymorphism and susceptibility to nasopharyngeal carcinoma
Author(s):
CHEN Jinglin1; LIANG Rongxin1; WANG Meijun1; YU Qingqing2
1.Department of Clinical Larboratory,Shiyan People’s Hospital,Hubei Shiyan 442000,China；2.Biomedical Research Institute,Hubei University of Medicine,Hubei Shiyan 442000,China.
Keywords:
nasopharyngeal carcinoma; ATP-binding cassette super G family member 2; mircoRNA; susceptibility
PACS:
R739.6
DOI:
10.3969/j.issn.1672-4992.2023.21.009
Abstract:
Objective:To investigate the relationship between ABCG2 and mircoRNA gene polymorphism and susceptibility to nasopharyngeal carcinoma.Methods:102 in patients with nasopharyngeal carcinoma in the department of oncology of our hospital from January 2019 to January 2023 were collected as the study subjects,and the polymorphism of ABCG2 gene,hsa-miR-499 and hsa-miR-608 gene were analyzed by collecting relevant clinical data and peripheral blood of patients with nasopharyngeal carcinoma and healthy subjects.Results:miR499:RS3746444(T→C) and miR608:RS4919510(C→G) showed significant differences between the study group and the control group(P<0.05). According to the risk factor analysis,compared to rs3746444TT,rs3746444C variant genotype(TC +CC) individuals had a 45% increased risk of nasopharyngeal carcinoma(OR=1.45,95%CI=1.05~1.78).The incidence of nasopharyngeal carcinoma in miR608:RS4919510(C→G) GC+GG gene was 1.53 times of CC gene(OR=1.53,95%CI=1.02~2.26).The distribution frequency of ABCG2 G34A gene GA+AA in nasopharyngeal carcinoma group was 57.84%,significantly higher than that in control group(32.00%)(OR=1.20,95%CI:1.02~1.42).If the allele was mutated from G to A,the risk was significantly increased(OR=1.18,95%CI:1.03~1.35).The mutation of ABCG2 C421A allele from C to A significantly increased the risk of nasopharyngeal carcinoma(OR=1.12,95%CI:1.02~1.29).ABCG2 G34A，ABCG2 C421AA significantly increased the risk of nasopharyngeal carcinoma.The 2-year survival rate was 91.18%(93/102),and there were no differences in gender,age,degree of differentiation,smoking,alcohol consumption,EBV infection and family genetic history(P>0.05).There were differences in TNM staging,lymph node metastasis,ABCG2 G34A,ABCG2 C421A,miR499:rs3746444(T→C) and miR608:rs4919510(C→G)(P<0.05).miR499+G34A+C421A+miR608 had the highest diagnostic value for nasopharyngeal carcinoma.Conclusion:ABCG2,miR499 and miR608 polymorphisms are associated with susceptibility to nasopharyngeal carcinoma,which are prognostic factors and have certain diagnostic value for nasopharyngeal carcinoma.

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Last Update: 2023-09-28