|Table of Contents|

Advances in the study of RNA-binding proteins involved in the metastatic process of hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 20
Page:
3884-3888
Research Field:
Publishing date:

Info

Title:
Advances in the study of RNA-binding proteins involved in the metastatic process of hepatocellular carcinoma
Author(s):
YUAN ZhangchenXU Feng
Department of General Surgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
Keywords:
hepatocellular carcinomametastasisRNA-binding proteins
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2023.20.033
Abstract:
RNA-binding proteins (RBPs) are functionally important proteins that bind to RNA molecules and accompany the regulation of RNA metabolism in a range of physiological processes in cells.In the metastatic process of liver cancer,the function of RBP is often abnormal.Based on the latest research,this paper summarizes the RBPs associated with hepatocellular carcinoma metastasis and reviews the specific mechanisms of their involvement in this process,with a view to providing new ideas or new approaches for new targets in cancer therapy.

References:

[1] LI W,DENG X,CHEN J.RNA-binding proteins in regulating mRNA stability and translation:roles and mechanisms in cancer [J].Semin Cancer Biol,2022,86(Pt 2):664-677.
[2] HASHIMOTO S,KISHIMOTO T.Roles of RNA-binding proteins in immune diseases and cancer [J].Semin Cancer Biol,2022,86(Pt 3):310-324.
[3] 中华人民共和国国家卫生健康委员会.原发性肝癌诊疗指南(2022年版)[J].肿瘤综合治疗电子杂志,2022,8(02):16-53. National Health Commission.Diagnosis and treatment guidelines for primary liver cancer (2022 edition) [J].Electronic Journal of Integrative Cancer Therapy,2022,8(02):16-53.
[4] WANG S,SUN Z,LEI Z,et al.RNA-binding proteins and cancer metastasis [J].Semin Cancer Biol,2022,86(Pt 2):748-768.
[5] WANG J,LIU Q,SHYR Y.Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis [J].BMC Genomics,2015,16(Suppl 7):S5.
[6] LUNDE BM,MOORE C,VARANI G.RNA-binding proteins:modular design for efficient function [J].Nat Rev Mol Cell Biol,2007,8(6):479-490.
[7] GARNEAU NL,WILUSZ J,WILUSZ CJ.The highways and byways of mRNA decay [J].Nat Rev Mol Cell Biol,2007,8(2):113-126.
[8] PERRON G,JANDAGHI P,SOLANKI S,et al.A general framework for interrogation of mRNA stability programs identifies RNA-binding proteins that govern cancer transcriptomes [J].Cell Rep,2018,23(6):1639-1650.
[9] DANG H,TAKAI A,FORGUES M,et al.Oncogenic activation of the RNA binding protein NELFE and MYC signaling in hepatocellular carcinoma [J].Cancer Cell,2017,32(1):101-114.
[10] HMMERLE M,GUTSCHNER T,UCKELMANN H,et al.Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1) [J].Hepatology,2013,58(5):1703-1712.
[11] BOO SH,KIM YK.The emerging role of RNA modifications in the regulation of mRNA stability [J].Exp Mol Med,2020,52(3):400-408.
[12] HAUSSMANN IU,BODI Z,SANCHEZ-MORAN E,et al.m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [J].Nature,2016,540(7632):301-304.
[13] WANG M,YANG Y,YANG J,et al.circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m(6)A-YTHDF3-Zeb1[J].Life Sci,2020,257:118082.
[14] 王进,毛德利,赵鑫,等.肝癌m6A RNA甲基化调控因子风险预测模型的构建及其临床意义[J].腹部外科,2021,34(6):467-473. WANG J,MAO DL,ZHAO X,et al.Construction of a risk prediction model for m6A RNA methylation regulatory factors in hepatoma and its clinical significance [J].Abdominal Surgery,2021,34(6):467-473.
[15] BONNAL SC,LPEZ-OREJA I,VALCRCEL J.Roles and mechanisms of alternative splicing in cancer-implications for care [J].Nat Rev Clin Oncol,2020,17(8):457-474.
[16] FU XD,ARES M.Context-dependent control of alternative splicing by RNA-binding proteins [J].Nat Rev Genet,2014,15(10):689-701.
[17] FRANKIW L,BALTIMORE D,LI G.Alternative mRNA splicing in cancer immunotherapy [J].Nat Rev Immunol,2019,19(11):675-687.
[18] QIN H,NI H,LIU Y,et al.RNA-binding proteins in tumor progression [J].J Hematol Oncol,2020,13(1):90.
[19] SUBRAMANIAN P,GARGANI S,PALLADINI A,et al.The RNA binding protein human antigen R is a gatekeeper of liver homeostasis [J].Hepatology,2022,75(4):881-897.
[20] LACHIONDO-ORTEGA S,DELGADO TC,BANOS-JAIME B,et al.Hu antigen R (HuR) protein structure,function and regulation in hepatobiliary tumors [J].Cancers (Basel),2022,14(11):2666.
[21] HUNG CM,HUANG WC,PAN HL,et al.Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells [J].Biomed Res Int,2014,2014:827415.
[22] 湛钊.HuR通过调控STRA6信号通路促进肝癌细胞的增殖、迁移及侵袭[D].贵阳:贵州医科大学,2021. ZHAN Z.HuR can promote the proliferation,migration and invasion of hepatoma cells by regulating STRA6 signaling pathway [D].Guiyang:Guizhou Medical University,2021.
[23] ZHANG Z,ZONG C,JIANG M,et al.Hepatic HuR modulates lipid homeostasis in response to high-fat diet [J].Nat Commun,2020,11(1):3067.
[24] BALVEY A,FERNANDEZ M.Translational control in liver disease [J].Front Physiol,2021,12:795298.
[25] 周思欣,卢灿荣,李沛雨,等.CPEB蛋白在肿瘤中的研究进展[J].临床合理用药杂志,2017,10(14):179-181. ZHOU SX,LU CR,LI PY,et al.Research progress of CPEB protein in tumor [J].Journal of Clinical Rational Drug Use,2017,10(14):179-181.
[26] ZHANG H,ZOU C,QIU Z,et al.CPEB3-mediated MTDH mRNA translational suppression restrains hepatocellular carcinoma progression [J].Cell Death Dis,2020,11(9):792.
[27] ZOU CD.MicroRNA-107:a novel promoter of tumor progression thattargets the CPEB3/EGFR axis in human hepatocellular carcinoma [J].Oncotarget,2016,7(1):266-278.
[28] SHU Z,GAO F,XIA Q,et al.MiR-9-5p promotes cell proliferation and migration of hepatocellular carcinoma by targeting CPEB3[J].Biomark Med,2021,15(2):97-108.
[29] LI Z,WU L,TAN W,et al.MiR-20b-5p promotes hepatocellular carcinoma cell proliferation,migration and invasion by down-regulating CPEB3[J].Ann Hepatol,2021,23:100345.
[30] 陈福海,郑安元,王永平,等.CPEB4在肿瘤中的研究进展 [J].临床耳鼻咽喉头颈外科杂志,2018,32(13):1038-1042. CHEN FH,ZHENG AY,WANG YP,et al.Research progress of CPEB4 in tumor [J].Journal of Clinical Otolaryngology Head and Neck Surgery,2018,32(13):1038-1042.
[31] TSAI LY,CHANG YW,LEE MC,et al.Biphasic and stage-associated expression of CPEB4 in hepatocellular carcinoma [J].PLoS One,2016,11(5):e0155025.
[32] CHENG X,LI M,RAO X,et al.KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA [J].Onco Targets Ther,2019,12:3421-3428.
[33] LAN T,LI H,ZHANG D,et al.KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3[J].Mol Cancer,2019,18(1):186.
[34] 黄芳芳,周诺.METTL3在RNA m~6A甲基化修饰的研究进展[J].生理科学进展,2019,50(06):458-463. HUANG FF,ZHOU N.Research progress of METTL3 methylation modification in RNA m~6A[J].Advances in Physiological Science,2019,50(06):458-463.
[35] 杨帆.METTL3通过介导pri-miR-93m~6A修饰促进肝癌细胞增殖的研究[D].长春:吉林大学,2021. YANG F.Study on the promotion of hepatoma cell proliferation by METTL3 mediated pri-miR-93m~6A modification [D].Changchun:Jilin University,2021.
[36] CHEN M,WEI L,LAW CT,et al.RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2[J].Hepatology,2018,67(6):2254-2270.
[37] RONG D,WU F,LU C,et al.m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression [J].Mol Ther Nucleic Acids,2021,26:637-648.
[38] 马金召.RNA m6A修饰及其催化基因METTL14在肝癌发生发展中的作用及机制研究[D].上海:第二军医大学,2017. MA JZ.The role and mechanism of RNA m6A modification and catalytic gene METTL14 in the development and development of liver cancer [D].Shanghai:Second Military Medical University,2017.
[39] MA JZ,YANG F,ZHOU CC,et al.METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6)-methyladenosine-dependent primary microRNA processing [J].Hepatology,2017,65(2):529-543.
[40] LI TH,QIN C,ZHAO BB,et al.Identification METTL18 as a potential prognosis biomarker and associated with immune infiltrates in hepatocellular carcinoma [J].Front Oncol,2021,11:665192.
[41] HOU J,ZHANG H,LIU J,et al.YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma [J].Mol Cancer,2019,18(1):163.
[42] ZHONG L,LIAO D,ZHANG M,et al.YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma [J].Cancer Lett,2019,442:252-261.
[43] YANG Z,LI J,FENG G,et al.MicroRNA-145 modulates N(6)-methyladenosine levels by targeting the 3'-untranslated mRNA region of the N(6)-methyladenosine binding YTH domain family 2 protein [J].J Biol Chem,2017,292(9):3614-3623.
[44] ZHANG C,HUANG S,ZHUANG H,et al.YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation [J].Oncogene,2020,39(23):4507-4518.
[45] ZHU H,CHEN K,CHEN Y,et al.RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis [J].Signal Transduct Target Ther,2022,7(1):240.
[46] WANG Q,GUO Y,WANG W,et al.RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA [J].Exp Cell Res,2021,399(1):112453.
[47] HAN L,HUANG C,ZHANG S.The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA [J].Liver Int,2019,39(11):2190-2203.
[48] YAN B,PENG Z,XING C.SORBS2,mediated by MEF2D,suppresses the metastasis of human hepatocellular carcinoma by inhibitiing the c-Abl-ERK signaling pathway [J].Am J Cancer Res,2019,9(12):2706-2718.
[49] LIU D,LUO X,XIE M,et al.HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression [J].Cancer Sci,2022,113(10):3347-3361.
[50] HUANG S,LUO K,JIANG L,et al.PCBP1 regulates the transcription and alternative splicing of metastasis-related genes and pathways in hepatocellular carcinoma [J].Sci Rep,2021,11(1):23356.
[51] QIAO Y,SHI Q,YUAN X,et al.RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma [J].Cancer Lett,2022,538:215711.
[52] XIAO Y,LI Y,SHI D,et al.MEX3C-mediated decay of SOCS3 mRNA promotes JAK2/STAT3 signaling to facilitate metastasis in hepatocellular carcinoma [J].Cancer Res,2022,82(22):4191-4205.
[53] D'AGOSTINO VG,SIGHEL D,ZUCAL C,et al.Screening approaches for targeting ribonucleoprotein complexes:A new dimension for drug discovery [J].SLAS Discov,2019,24(3):314-331.
[54] CROOKE ST,BAKER BF,CROOKE RM,et al.Antisense technology:an overview and prospectus [J].Nat Rev Drug Discov,2021,20(6):427-453.
[55] SHINKAI K,NAKANO K,CUI L,et al.Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models [J].Int J Cancer,2016,139(2):433-445.
[56] WU X,GARDASHOVA G,LAN L,et al.Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis [J].Commun Biol,2020,3(1):193.
[57] VAN NOSTRAND EL,FREESE P,PRATT GA,et al.A large-scale binding and functional map of human RNA-binding proteins [J].Nature,2020,583(7818):711-719.
[58] ZHANG Y,LI Z.RNA binding proteins:Linking mechanotransduction and tumor metastasis [J].Cancer Lett,2021,496:30-40.

Memo

Memo:
辽宁省自然科学基金项目(编号:20180551193,2020-MS-181);盛京医院345人才工程计划(编号:40B)
Last Update: 1900-01-01