«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2023 20

Page:

3865-3870

Research Field:

Publishing date:

Info

Title:

Research progress on biological function of exosome circular RNA in breast cancer

Author(s):

SHI Xiaohui¹; HAO Ran²; QI Yixin¹

1.Department of Breast Center,the Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050035,China;2.School of Nursing,Hebei Medical University,Hebei Shijiazhuang 050030,China.

Keywords:

breast cancer; exosome; circular RNA; precision medicine

PACS:

R737.9

DOI:

10.3969/j.issn.1672-4992.2023.20.029

Abstract:

The incidence of breast cancer£¨BC£© is increasing and surpassed lung cancer to become the first in the world.With the rapid development of BC diagnosis and treatment technology,the prognosis of patients has been greatly improved,but recurrence,metastasis and chemotherapy resistance are still the main causes of death in BC patients.Therefore,it is particularly urgent to explore new molecular markers which play a key role in the occurrence,development,diagnosis and treatment of BC.Circular RNA £¨circRNA£© has been widely studied and confirmed in the field of molecular markers because of its unique stable circular structure and its regulatory role in various diseases.At the same time,researchers have found that exosomes widely distributed in various body fluids can be used as an important carrier of circRNA in intercellular communication.The stable structure of circRNA and the convenience of exosome sampling make their combination have important research value in cancer.This article summarizes the biological function and clinical value of exosome circRNA in BC.

References:

£Û1£Ý SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries £ÛJ£Ý.CA A Cancer J Clin,2021,71(3):209-249.
£Û2£Ý ALVAREZ EM,FORCE LM,XU R,et al.The global burden of adolescent and young adult cancer in 2019:a systematic analysis for the Global Burden of Disease Study 2019£ÛJ£Ý.The Lancet Oncolog,2022,23(1):27-52.
£Û3£Ý WAKS AG,WINER EP.Breast cancer treatment:a review £ÛJ£Ý.JAMA,2019,321(3):288-300.
£Û4£Ý YU W,HURLEY J,ROBERTS D,et al.Exosome-based liquid biopsies in cancer:opportunities and challenges £ÛJ£Ý.Ann Oncol,2021,32(4):466-477.
£Û5£Ý VAN NIEL G,D'ANGELO G,RAPOSO G.Shedding light on the cell biology of extracellular vesicles £ÛJ£Ý.Nat Rev Mol Cell Biol,2018,19(4):213-228.
£Û6£Ý ROBBINS PD,MORELLI AE.Regulation of immune responses by extracellular vesicles £ÛJ£Ý.Nat Rev Immunol,2014,14(3):195-208.
£Û7£Ý OLEJARZ W,KUBIAK-TOMASZEWSKA G,CHRZANOWSKA A,et al.Exosomes in angiogenesis and anti-angiogenic therapy in cancers £ÛJ£Ý.Int J Mol Sci,2020,21(16):5840.
£Û8£Ý NOONIN C,THONGBOONKERD V.Exosome-inflammasome crosstalk and their roles in inflammatory responses £ÛJ£Ý.Theranostics,2021,11(9):4436-4451.
£Û9£Ý WORTZEL I,DROR S,KENIFIC CM,et al.Exosome-mediated metastasis:communication from a distance £ÛJ£Ý.Dev Cell,2019,49(3):347-360.
£Û10£Ý BAI X,NI J,BERETOV J,et al.Cancer stem cell in breast cancer therapeutic resistance £ÛJ£Ý.Cancer Treat Rev,2018,69:152-163.
£Û11£Ý XU J,CAMFIELD R,GORSKI SM.The interplay between exosomes and autophagy-partners in crime £ÛJ£Ý.J Cell Sci,2018,131(15):jcs215210.
£Û12£Ý TOMASETTI M,LEE W,SANTARELLI L,et al.Exosome-derived microRNAs in cancer metabolism:possible implications in cancer diagnostics and therapy £ÛJ£Ý.Exp Mol Med,2017,49(1):e285.
£Û13£Ý SUN Z,YANG S,ZHOU Q,et al.Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment £ÛJ£Ý.Mol Cancer,2018,17(1):82.
£Û14£Ý JENA BC,MANDAL M.The emerging roles of exosomes in anti-cancer drug resistance and tumor progression:An insight towards tumor-microenvironment interaction £ÛJ£Ý.Biochim Biophys Acta Rev Cancer,2021,1875(1):188488.
£Û15£Ý VALADI H,EKSTR¦ZM K,BOSSIOS A,et al.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells £ÛJ£Ý.Nat Cell Biol,2007,9(6):654-659.
£Û16£Ý SUN Z.Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment £ÛJ£Ý.Mol Cancer,2018,17(1):82.
£Û17£Ý FAN Q,YANG L,ZHANG X,et al.The emerging role of exosome-derived non-coding RNAs in cancer biology £ÛJ£Ý.Cancer Lett,2018,414:107-115.
£Û18£Ý HANNAFON B,DING WQ.Intercellular communication by exosome-derived microRNAs in cancer £ÛJ£Ý.Int J Mol Sci,2013,14(7):14240-14269.
£Û19£Ý KRISTENSEN LS,ANDERSEN MS,STAGSTED LVW,et al.The biogenesis,biology and characterization of circular RNAs £ÛJ£Ý.Nat Rev Genet,2019,20(11):675-691.
£Û20£Ý GUO L,JIA L,LUO L,et al.Critical roles of circular RNA in tumor metastasis via acting as a sponge of miRNA/isomiR £ÛJ£Ý.Int J Mol Sci,2022,23(13):7024.
£Û21£Ý KRISTENSEN LS,JAKOBSEN T,HAGER H,et al.The emerging roles of circRNAs in cancer and oncology £ÛJ£Ý.Nat Rev Clin Oncol,2022,19(3):188-206.
£Û22£Ý SINHA T,PANIGRAHI C,DAS D,et al.Circular RNA translation,a path to hidden proteome £ÛJ£Ý.Wiley Interdiscip Rev RNA,2022,13(1):e1685.
£Û23£Ý WANG Y,WU C,DU Y,et al.Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomasv £ÛJ£Ý.Mol Cancer,2022,21(1):13.
£Û24£Ý KONG S,TAO M,SHEN X,et al.Translatable circRNAs and lncRNAs:Driving mechanisms and functions of their translation products £ÛJ£Ý.Cancer Lett,2020,483:59-65.
£Û25£Ý LIN H,YU J,GU X,et al.Novel insights into exosomal circular RNAs:Redefining intercellular communication in cancer biology £ÛJ£Ý.Clin Transl Med,2021,11(12):e636.
£Û26£Ý AMICONE L,MARCHETTI A,CICCHINI C.Exosome-associated circRNAs as key regulators of EMT in cancer £ÛJ£Ý.Cells,2022,11(10):1716.
£Û27£Ý LI J,ZHANG G,LIU CG,et al.The potential role of exosomal circRNAs in the tumor microenvironment:insights into cancer diagnosis and therapy £ÛJ£Ý.Theranostics,2022,12(1):87-104.
£Û28£Ý LI Y,ZHENG Q,BAO C,et al.Circular RNA is enriched and stable in exosomes:a promising biomarker for cancer diagnosis £ÛJ£Ý.Cell Res,2015,25(8):981-984.
£Û29£Ý LASDA E,PARKER R.Circular RNAs co-precipitate with extracellular vesicles:a possible mechanism for circrna clearance £ÛJ£Ý.PLoS One,2016,11(2):e0148407.
£Û30£Ý RAPOSO G,STOORVOGEL W.Extracellular vesicles:exosomes,microvesicles,and friends £ÛJ£Ý.J Cell Biol,2013,200(4):373-383.
£Û31£Ý CHOI D,LEE TH,SPINELLI C,et al.Extracellular vesicle communication pathways as regulatory targets of oncogenic transformation £ÛJ£Ý.Semin Cell Dev Biol,2017,67:11-22.
£Û32£Ý KILINC S,PAISNER R,CAMARDA R,et al.Oncogene-regulated release of extracellular vesicles £ÛJ£Ý.Dev Cell,2021,56(13):1989-2006.
£Û33£Ý HANNAFON BN,TRIGOSO YD,CALLOWAY CL,et al.Plasma exosome microRNAs are indicative of breast cancer £ÛJ£Ý.Breast Cancer Res,2016,18(1):90.
£Û34£Ý JOYCE DP,KERIN MJ.Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer £ÛJ£Ý.Int J Cancer,2016,139(7):1443-1448.
£Û35£Ý RODR¦PGUEZ-MART¦PNEZ A,DE MIGUEL-P¦IREZ D,ORTEGA FG,et al.Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy £ÛJ£Ý.Breast Cancer Res,2019,21(1):21.
£Û36£Ý LUO J,XIONG Y,FU PF,et al.Exosomal long non-coding RNAs:biological properties and therapeutic potential in cancer treatment £ÛJ£Ý.J Zhejiang Univ Sci B,2019,20(6):488-495.
£Û37£Ý WANG H,SHU L,NIU N,et al.Novel lncRNAs with diagnostic or prognostic value screened out from breast cancer via bioinformatics analyses £ÛJ£Ý.PeerJ,2022,10:e13641.
£Û38£Ý WANG J,ZHANG Q,ZHOU S,et al.Circular RNA expression in exosomes derived from breast cancer cells and patients £ÛJ£Ý.Epigenomics,2019,11(4):411-421.
£Û39£Ý YANG SJ,WANG DD,ZHOU SY,et al.Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer £ÛJ£Ý.Epigenomics,2020,12(2):101-125.
£Û40£Ý LIU J,PENG X,LIU Y,et al.The diagnostic value of serum exosomal has_circ_0000615 for breast cancer patients £ÛJ£Ý.Int J Gen Med,2021,14:4545-4554.
£Û41£Ý ZHOU H,HE X,HE Y,et al.Exosomal circRNAs:emerging players in tumor metastasis £ÛJ£Ý.Front Cell Dev Biol,2021,9:786224.
£Û42£Ý LIN Q,QI Q,HOU S,et al.Exosomal circular RNA hsa_circ_007293 promotes proliferation,migration,invasion,and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis £ÛJ£Ý.Bioengineered,2021,12(2):10136-10149.
£Û43£Ý ZHANG L,ZHANG J,LI P,et al.Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3£ÛJ£Ý.Cell Death Dis,2022,13(1):32.
£Û44£Ý ZHOU H,HUANG X,YANG X,et al.CircRAPGEF5 promotes the proliferation and metastasis of lung adenocarcinoma through the miR-1236-3p/ZEB1 axis and serves as a potential biomarker £ÛJ£Ý.Int J Biol Sci,2022,18(5):2116-2131.
£Û45£Ý TURCO C,ESPOSITO G,IAIZA A,et al.MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer £ÛJ£Ý.Commun Biol,2022,5(1):598.
£Û46£Ý DU WW,LI X,MA J,et al.Promotion of tumor progression by exosome transmission of circular RNA circSKA3£ÛJ£Ý.Mol Ther Nucleic Acids,2021,27:276-292.
£Û47£Ý L¦a¦ZND F,SUGIYAMA N,BILL R,et al.Distinct contributions of partial and full EMT to breast cancer malignancy £ÛJ£Ý.Dev Cell,2021,56(23):3203-3221.
£Û48£Ý CHEN X,CHEN RX,WEI WS,et al.PRMT5 circular rna promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition £ÛJ£Ý.Clin Cancer Res,2018,24(24):6319-6330.
£Û49£Ý YANG SJ,WANG DD,ZHONG SL,et al.Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis,metastasis,and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/¦Â-catenin (cyclin D1) axis £ÛJ£Ý.Cell Death Dis,2021,12(5):420.
£Û50£Ý LU C,SHI W,HU W,et al.Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression £ÛJ£Ý.Pharmacol Res,2022,177:106098.
£Û51£Ý YU T,WANG Y,FAN Y,et al.CircRNAs in cancer metabolism:a review £ÛJ£Ý.J Hematol Oncol,2019,12(1):90.
£Û52£Ý CHEN T,WANG X,LI C,et al.CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation £ÛJ£Ý.Oncogene,2021,40(15):2756-2771.
£Û53£Ý ZHAN Y,DU J,MIN Z,et al.Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress £ÛJ£Ý.Cell Death Discov,2021,7(1):141.
£Û54£Ý LIU Y,MA L,HUA F,et al.Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer £ÛJ£Ý.Oncogene,2022,41(14):2012-2025.
£Û55£Ý SHI P,LIU Y,YANG H,et al.Breast cancer derived exosomes promoted angiogenesis of endothelial cells in microenvironment via circHIPK3/miR-124-3p/MTDH axis £ÛJ£Ý.Cell Signal,2022,95:110338.
£Û56£Ý ZHOU B,MO Z,LAI G,et al.Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-¦ÊB-IL-6 axis of tumor-associated macrophages £ÛJ£Ý.J Exp Clin Cancer Res,2023,42(1):48.
£Û57£Ý WANG H,GONG P,CHEN T,et al.Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres £ÛJ£Ý.Adv Sci (Weinh),2021,8(8):2004320.
£Û58£Ý MEISENBERG C,ASHOUR ME,EL-SHAFIE L,et al.Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan £ÛJ£Ý.Nucleic Acids Res,2017£¬45(3):1159-1176.
£Û59£Ý ADAM-ARTIGUES A,ARENAS EJ,MART¦PNEZ-SABADELL A,et al.Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer £ÛJ£Ý.Sci Adv,2022,8(20):eabk2746.
£Û60£Ý JACKSON LM,DHOONMOON A,HALE A,et al.Loss of MED12 activates the TGF¦Â pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells £ÛJ£Ý.Nucleic Acids Res,2021,49(22):12855-12869.
£Û61£Ý GAO Z,HAN X,ZHU Y,et al.Drug-resistant cancer cell-derived exosomal EphA2 promotes breast cancer metastasis via the EphA2-Ephrin A1 reverse signaling £ÛJ£Ý.Cell Death Dis,2021,12(5):414.
£Û62£Ý ZHAO L,LIU W,XIAO J,et al.The role of exosomes and "exosomal shuttle microRNA" in tumorigenesis and drug resistance £ÛJ£Ý.Cancer Lett,2015,356(2 Pt B):339-346.
£Û63£Ý CHEN SW,ZHU SQ,PEI X,et al.Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC£ÛJ£Ý.Mol Cancer,2021,20(1):144.
£Û64£Ý HU K,LIU X,LI Y,et al.Exosomes mediated transfer of circ_UBE2D2 enhances the resistance of breast cancer to tamoxifen by binding to miR-200a-3p£ÛJ£Ý.Med Sci Monit,2020,26:e922253.
£Û65£Ý WU X,REN Y,YAO R,et al.Circular RNA circ-MMP11 contributes to lapatinib resistance of breast cancer cells by regulating the miR-153-3p/ANLN axis £ÛJ£Ý.Front Oncol,2021,11:639961.
£Û66£Ý WANG X,CHEN T,LI C,et al.CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR£ÛJ£Ý.J Hematol Oncol,2022,15(1):122.
£Û67£Ý SAEEDI S,ISRAEL S,NAGY C,et al.The emerging role of exosomes in mental disorders £ÛJ£Ý.Transl Psychiatry,2019,9(1):122.
£Û68£Ý M¦ZLLER A,LOBB RJ.The evolving translational potential of small extracellular vesicles in cancer £ÛJ£Ý.Nat Rev Cancer,2020,20(12):697-709.
£Û69£Ý CHEN CC,LIU L,MA F,et al.Elucidation of exosome migration across the blood-brain barrier model in vitro £ÛJ£Ý.Cell Mol Bioeng,2016,9(4):509-529.
£Û70£Ý BATRAKOVA EV,KIM MS.Using exosomes,naturally-equipped nanocarriers,for drug delivery £ÛJ£Ý.J Control Release,2015,219:396-405.
£Û71£Ý ZHANG L,LIANG D,CHEN C,et al.Circular siRNAs for reducing off-target effects and enhancing long-term gene silencing in cells and mice £ÛJ£Ý.Mol Ther Nucleic Acids,2018,10:237-244.
£Û72£Ý YI Z,QU L,TANG H,et al.Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo £ÛJ£Ý.Nat Biotechnol,2022,40(6):946-955.
£Û73£Ý WESSELHOEFT RA,KOWALSKI PS,ANDERSON DG.Engineering circular RNA for potent and stable translation in eukaryotic cells £ÛJ£Ý.Nat Commun,2018,9(1):2629.
£Û74£Ý LI Z,ZHOU X,WEI M,et al.In vitro and in vivo RNA inhibition by CD9-HuR functionalized exosomes encapsulated with miRNA or CRISPR/dCas9£ÛJ£Ý.Nano Lett,2019,19(1):19-28.
£Û75£Ý ZHANG PF,GAO C,HUANG XY,et al.Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma £ÛJ£Ý.Mol Cancer,2020,19(1):110.
£Û76£Ý LI J,ZHANG G,LIU CG,et al.The potential role of exosomal circRNAs in the tumor microenvironment:insights into cancer diagnosis and therapy £ÛJ£Ý.Theranostics,2022,12(1):87-104.
£Û77£Ý HUSSEN BM,MOHAMADTAHR S,ABDULLAH SR,et al.Exosomal circular RNAs:New player in breast cancer progression and therapeutic targets £ÛJ£Ý.Front Genet,2023,14:1126944.
£Û78£Ý LI H,PENG K,YANG K,et al.Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies £ÛJ£Ý.Theranostics,2022,12(14):6422-6436.
£Û79£Ý XU Z,ZENG S,GONG Z,et al.Exosome-based immunotherapy:a promising approach for cancer treatment £ÛJ£Ý.Mol Cancer,2020,19(1):160.

Memo

Memo:

National Natural Science Foundation of China(No.72074067£©£»¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð£¨±àºÅ£º72074067£©;ºÓ±±Ê¡¿Æ¼¼ÌüÖصãÑз¢¼Æ»®ÏîÄ¿£¨±àºÅ£º21377729D£©;ºÓ±±Ê¡×ÔÈ»»ù½ð¾«×¼Ò½Ñ§ÁªºÏ»ù½ðÅàÓýÏîÄ¿£¨±àºÅ£ºH2020206483,H2021206289£©;ºÓ±±Ò½¿Æ´óѧ¡°µ¼Ê¦ÖÆ-ÇàÄê¿Æ¼¼´´ÐÂÈ˲ÅÍоÙÅàÓý¼Æ»®¡±ÏîÄ¿£¨±àºÅ£ºTJSK202103£©;ºÓ±±Ò½¿Æ´óѧ×ÔÈ»¿ÆѧÁìÓòÇàÄê¿Æ¼¼È˲ÅÖ§³Ö¼Æ»®ÏîÄ¿£¨±àºÅ£ºCYCZ2021012£©

Common functions

Last Update: 1900-01-01