|Table of Contents|

Clinical characteristics of HR negative breast cancer with low expression of HER2 and research progress of new antibody-drug conjugate therapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 19
Page:
3673-3678
Research Field:
Publishing date:

Info

Title:
Clinical characteristics of HR negative breast cancer with low expression of HER2 and research progress of new antibody-drug conjugate therapy
Author(s):
CAI Xinyi1ZHANG Hongmei2WANG Xiaowen2
1.Fourth Cadet Brigade,Department of Basic Medicine,Air Force Medical University,Shaanxi Xi'an 710032,China;2.Department of Clinical Oncology,the First Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710032,China.
Keywords:
breast cancerhuman epidermal growth factor receptor 2 low expressionhormone receptor negativeantibody-drug conjugate
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2023.19.028
Abstract:
Breast cancer is the most common malignant tumor in women.Nearly half of the patients are low expression of human epidermal growth factor receptor 2(HER2),and are not sensitive to traditional anti-HER2 targeted therapy.The new antibody-drug conjugates(ADC) overcome the heterogeneity of HER2 expression through the "bystander effect",and provide new targeted treatment options for breast cancer patients with HER2 low expression,especially for the HER2 low expression and hormone receptor(HR) negative population with poor prognosis and limited treatment.The new ADC completely changes the treatment pattern and prognosis of HER2 low expression and HR negative patients.This article reviewed the clinical characteristics of HER2 low expression and HR negative breast cancer patients and the related ADC research progress.

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Memo

Memo:
National Natural Science Foundation of China(No.81702711);国家自然科学基金项目(编号:81702711);陕西省自然科学基础研究计划(编号:2018JQ8013);陕西省西安市科协青年人才托举计划(编号:95920201329);空军军医大学校发展基金(编号:2022XC024)
Last Update: 2023-08-31